Sentences with phrase «t cell adhesion»

As described below, however, the LPA / LPA2 axis appears to affect T cell adhesion on the surfaces coated with LFA -1-ligand or fibronectin.

Not exact matches

This drug (vedolizumab) blocks a specific adhesion molecule on the surface of the T - cell and thereby inhibits immune cells from binding themselves to receptors present in the intestine, preventing the T - cells from penetrating the blood vessels in the intestinal tissue.

This work outlines how a receptor termed LFA - 1 on the surface of T - cells mediates adhesion to other cells such as cancer cells.

Monika Raab, Yuning Lu, Karsten Kohler, Xin Smith, Klaus Strebhardt & Christopher E. Rudd, «LFA - 1 activates focal adhesion kinases FAK1 / PYK2 to generate LAT - GRB2 - SKAP1 complexes that terminate T - cell conjugate formation», Nature Communications, 2017 July 12.

A study has shown that the immunosuppressive effect of MSCs is mediated by the secretion of galectin - 3, a protein known to modulate T cell proliferation, gene expression, cell adhesion and migration 44.

Choi EY, Chavakis E, Czabanka MA, Langer H, Fraemohs L, Economopoulou M, Kundu RK, Orlandi A, Zheng YY, Prieto DA, Ballantyne CM, Constant SL, Aird W, Papayannopoulou T, Gahmberg CG, Udey MC, Vajkoczy P, Quertermous T, Dimmeler S, Weber C, and Chavakis T. Del - 1, an endogenous leukocyte - endothelial adhesion inhibitor, limits inflammatory cell recruitment.

Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5

Taken together, these results strongly suggest that the LPA2 signaling modulates T cell motility in the confined environments at least partly in an integrin - independent manner and may also act on cell adhesion to prevent over-adhesion to the substrates.

This LPA's effect was not observed in LPA2 - / - T cells, which was also the same with cell adhesion to the fibronectin - coated substrate (Figure 8A - C).