Sentences with phrase «t cell clones»
He and his colleagues were the first to demonstrate that human antigen - specific T cell clones could be isolated and expanded in vitro and then re-infused into patients to prevent or treat viral infections and to mediate therapeutic responses in patients with cancer.
http://www.immunedesign.com/
Analysis of variant - specific antigens by selection of antigen - loss variants with cytolytic T cell clones.
Anichini A, Maccalli C, Mortarini R, Salvi S, Mazzocchi A, Squarcina P, Herlyn M, Parmiani G. Melanoma cells and normal melanocytes share antigens recognized by HLA - A2 - restricted cytotoxic T cell clones from melanoma patients.
If T cell clones created before birth can stick around for decades, they might account for a substantial amount of shared T cells between any two unrelated people.
It is not clear whether all of the T cell clones that respond to the initial infection have the potential to form memory T cells.
The cytokines speed up T cell cloning and knock down regulatory T cells, which put the brakes on the cloning process.
Not exact matches
«Immune system cell clones created before birth may last for decades: Identical twins may exchange T cells through cord blood before birth.»
Poor overall survival was associated with higher T - cell diversity (that is, higher clone - to - TIL ratios).
The ability of tumor - infiltrating lymphocytes (TILs) such as T cells to produce multitudes of clones that overwhelm and effectively control cancer cells has been demonstrated, but the significance of the composition of T - cell repertories is unknown.
The analysis suggests that the degree of T - cell clone sharing between twins is greater than can be explained simply by shared genomes.
In the new study, Mikhail Pogorelyy and colleagues from the Ecole normale supérieure in Paris, and the Shemyakin - Ovchinnikov Institute of Bioorganic Chemistry, Moscow, address this excess of T - cell clone sharing between genetically identical twins.
If the T cells judge the pieces to be foreign or in need of removal, they reproduce, forming an army of clones that hunt down infected and rogue cells in the body.
Geneticist at the University of Toronto in Canada, the first to clone the T - cell receptor, discusses how a scientific breakthrough can change your life:
He is part of the team that cloned the gene for the human T cell receptor in 1984, which he describes as «the Holy Grail of immunology.»
Dr. Mak is an internationally acclaimed immunologist renowned for his 1984 cloning of the genes encoding the human T - cell receptor.
CHICAGO, Ill. — The ability of tumor - infiltrating lymphocytes (TILs) such as T cells to produce multitudes of clones that overwhelm and effectively control cancer cells has been demonstrated, but the significance of the composition of T - cell repertories is unknown.
Molecular cloning of SLP - 76, a 76 - kDa tyrosine phosphoprotein associated with Grb2 in T cells.
Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.
Researchers in the laboratory of Richard A. Axel, including Leonard Chess and Dan Littman, clone the genes for the CD4 [i] and CD8 [ii] T cell surface proteins.
Lloyd Old, Thierry Boon, and colleagues develop the TNF release assay for mouse systems in which release of TNF by T cells could be used to assess specific T cell recognition, facilitating the cloning of human tumor antigens.
Gene cloned from T - cell - tropic HIV - 1 MN strain and the full length recombinant envelope gp120 glycoprotein produced in the Baculovirus Expression System
The parent TZM - bl cell line is an engineered HeLa cell clone that expresses human CD4, CCR5 and CXCR4 and contains HIV - 1 T
To determine if T - cell - mediated immunoselection was responsible for the outgrowth of the escape tumors, Matsushita et al performed a fascinating experiment using a mixture of cells from two d42m1 clones:
Through patients» T cell analysis, Dr. Matsuzaki cloned and analyzed function of NY - ESO -1-specific CD8 + and CD4 + T cells.
«This is the first time anyone has succeeded in cloning a T - cell receptor targeting prostate antigen, and we hope we will have an opportunity to test T cells equipped with this receptor in a clinical study.
However, if it is known which unique antigen is expressed by a tumour cell type, it should be possible to clone a T - cell receptor that has the capacity to bind to that antigen.