Sentences with phrase «t cell cytotoxicity»

EOS100850 potently rescues Th1 cytokine production in human whole blood treated by A2A agonists, and increased CD8 + T cell cytotoxicity in a co-culture assay of effector CD8 + T cells and target cancer cells

Similarly, antigen - specific CD4 + CD25 + regulatory T cells also suppress tumor - specific CD8 T cell cytotoxicity although this mechanism relies on TGF - β secretion by regulatory cells 196, 197.

Not exact matches

Dsg3 CAAR - T cells exhibit specific cytotoxicity against cells expressing anti-Dsg3 BCRs in vitro and expand, persist, and specifically eliminate Dsg3 - specific B cells in vivo.

In their study, DN T cells displayed allospecific cytotoxicity in vitro and mediated tumor allograft rejection in vivo.

The mechanism of action is based on the activation of macrophages to defend against tumors by direct tumor cytotoxicity and consequently they secrete cytokines which recruit secondary immune cells, presenting antigen to T cells [5 - 7].

IFN - α Augments NK - mediated Antibody - Dependent Cellular Cytotoxicity (ADCC) of HIV - 1 Infected Autologous CD4 + T Cells Regardless of MHC - I Downregulation.

A new study demonstrates that it is possible to vaccinate patients with MDS against a decitabine - induced antigen and that the level of induced expression is sufficient to trigger cytotoxicity in patient - derived vaccine - induced T cells.

Then, we systematically compared the effect of the hinge domains on the growth kinetics, cytokine production, and cytotoxicity of CAR T cells in vitro and in vivo.

For example, studies of medical students facing examinations and kindergarten children beginning school reveal changes in immune functioning potentially prognostic for adverse health outcomes, including changes in numbers of total t - lymphocytes, natural killer cell cytotoxicity, and lymphocyte responsivity to mitogenic stimulation (e.g., 8, 9).