Sentences with phrase «t cell dysfunction»

His plans for research in his own lab involve «continuing to look at the mechanisms of T cell dysfunction in human and mice.

Our findings show how the tumor microenvironment drives the acquisition of CD39 as an immune regulatory molecule on CD8 + T cells, with implications for defining a biomarker of T cell dysfunction and a target for immunotherapeutic intervention.

Not exact matches

In March 2016, Penn researchers published a study in Blood that showed long - term ibrutinib treatment reverses the dysfunction of T cells in CLL and that combining CAR therapy with ibrutinib enhanced engineered T cell proliferation in mice.

When spleen CD4 + T - cells were transferred from heart - attack donor mice to naïve recipient mice, they induced long - term left ventricle dysfunction, fibrosis and enlargement, hallmarks of heart failure.

Research Interests: Tumor immunity, T lymphocyte effectors, immunotherapy, T - cell dysfunction in cancer, myeloid derived suppressor cells (MDSC) and angiogenesis

Maccari ME, Scarselli A, Di Cesare S, Floris M, Angius A, Deodati A, Chiriaco M, Cambiaso P, Corrente S, Colafati GS, Utz PJ, Angelini F, Fierabracci A, Aiuti A, Carsetti R, Rosenberg JM, Cappa M, Rossi P, Bacchetta R, Cancrini C. Severe toxoplasma gondii infection in a member of a NFKB2 - deficient family with T and B cell dysfunction.

Upregulation of PD - 1 expression on HIV - specific CD8 + T cells leads to reversible immune dysfunction.

A team of chemical and biomedical engineers from the Cockrell School of Engineering at The University of Texas at Austin, in collaboration with researchers from the University of Pennsylvania, have discovered that HIV - infected patients experience a dysfunction in a certain type of immune cell: the follicular helper T (Tfh) cell.