Sentences with phrase «t cell growth»

The Akt / mTOR pathway plays a key role in the induction of aerobic glycolysis and anabolic processes in T cell growth.

Those findings could mean that vaccines delivered via nasal spray instead of shots might stimulate memory T cell growth in the nose and could protect lungs from damage as well.

Not exact matches

These growth modulators are produced either by the epithelial cells of the mammary gland or by activated macrophages, lymphocytes (mainly T cells), or neutrophils in the milk.

«To my great surprise, even injecting 10 million activated T cells specific to the P1A antigen did not affect tumor growth in this induced tumor model,» says Van den Eynde.

The research team found that injection of CAR T cells into 79 immunodeficient mice arrested the growth of GBM in 60 % of them.

IL - 15 is a growth factor for certain kinds of white blood cells including natural killer cells and T cells.

In pancreatic cancer, their activity boosts tumor growth and spread, and may also help suppress T cells and other immune elements that would otherwise attack the tumor.

The team also detected high levels of interferon gammaa protein produced by T cells that blocks the growth of viruses and renders cells resistant to viral infection.

Under normal conditions, T - cells and other immune cells collaborate to mount an immune response to invading mycobacteria, ultimately controlling their growth.

In experiments in mice, UC San Francisco researchers have discovered that regulatory T cells (Tregs; pronounced «tee - regs»), a type of immune cell generally associated with controlling inflammation, directly trigger stem cells in the skin to promote healthy hair growth.

On the safety side, the panelists delved into the possible risks of injecting genetically modified cells into patients, including the potential for deadly viral infections, brain toxicity, and, paradoxically, the growth of new tumors brought about by CAR - T cells years after treatment.

Tumors escape from the fighter T - cells that would otherwise attack them, by tricking the immune system and making an environment ripe for tumor growth.

Moreover, injection of 5E5 CAR T cells into mice with leukemia or pancreatic cancer reduced tumor growth and increased survival.

«An important possible advantage to this approach is that these therapeutic T cells have the potential to replicate in the body, and therefore they might suppress tumor growth and prevent relapse for a prolonged period,» Yu says.

Subsequent tests revealed that the retrovirus used to ferry the corrective gene into the DNA of blood - making cells in the bone marrow had lodged in or near a gene that regulates T cells, possibly prompting their uncontrolled growth.

When antibodies and other methods were used to dramatically deplete the supply of Tregs in mice, the researchers saw a dramatic jump in the numbers of activated dendritic cells and CD8 + T cells in pancreatic tumor tissue, as well as a slowing of tumor growth.

Scientists have known that LPA is secreted by many types of cancer cells, appears to promote the growth and spread of tumor cells, and that immune cells known as CD - 8 «killer» T cells have several receptors for LPA.

When they transferred T cells lacking the LPA5 receptor into mice with cancer, tumor growth essentially halted.

Thus, treatment with X4 - ZFNs of both wild - type and ccr5Δ32 CD4 + T cells confers stable cxcr4 disruption and a marked survival advantage in the presence of R5X4 - HIV and X4 - HIV in vitro without any detectable effect on cell growth or viability in the absence of HIV.

g (acceleration due to gravity) G (gravitational constant) G star G1.9 +0.3 gabbro Gabor, Dennis (1900 — 1979) Gabriel's Horn Gacrux (Gamma Crucis) gadolinium Gagarin, Yuri Alexeyevich (1934 — 1968) Gagarin Cosmonaut Training Center GAIA Gaia Hypothesis galactic anticenter galactic bulge galactic center Galactic Club galactic coordinates galactic disk galactic empire galactic equator galactic habitable zone galactic halo galactic magnetic field galactic noise galactic plane galactic rotation galactose Galatea GALAXIES galaxy galaxy cannibalism galaxy classification galaxy formation galaxy interaction galaxy merger Galaxy, The Galaxy satellite series Gale Crater Galen (c. 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The frequency of CD39highCD8 + T cells increased with tumor growth but was absent in lymphoid organs.

Cell contact, prostaglandin E (2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4 + CD25 (High) forkhead box P3 + regulatory T cells.Clin Exp Immunol 2009; 156: 149 - Cell contact, prostaglandin E (2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4 + CD25 (High) forkhead box P3 + regulatory T cells.Clin Exp Immunol 2009; 156: 149 - cell induction of CD4 + CD25 (High) forkhead box P3 + regulatory T cells.Clin Exp Immunol 2009; 156: 149 - 160.

Finally, we demonstrate that treatment of T - 47D cells with epidermal growth factor (EGF), which promotes cell ruffling, stimulates increased accumulation of activated matriptase at the sites of membrane ruffling, suggesting a possible functional role at these sites.

We further determined that T cells deficient in DGKζ exhibit greater control of murine pancreatic tumor growth as compared with T cells deficient in Cbl - b.

IL - 10 is likely to be suppressing potential allo - responsiveness because it is a recognized growth factor for regulatory T cells 168.

Abbreviations: AD - MSC: adipose tissue derived mesenchymal stem cells; APC: antigen presenting cell; BM: bone marrow; CNI: calcineurin inhibitor; DC: dendritic cells; GVHD: graft - versus - host disease; HLA: histocompatibility locus antigen; HGF: hepatocyte growth factor; IL: interleukin; IDO: indoleamine 2,3 - dioxygenase; MLR: mixed lymphocyte reaction; MSC: mesenchymal stem cells; PGE2: prostaglandin E2; SC: stem cells; TGF: transforming growth factor; TH: T - helper; T - regs: T - regulatory cells.

Nakano S, Nagasawa T, Ijiro T, Inada Y, Tamura T, Maruyama K, Kuroda J, Yamazaki Y, Kusama H, Shibata N. Bezafibrate prevents hepatic stellate cell activation and fibrogenesis in a murine steatohepatitis model, and suppresses fibrogenic response induced by transforming growth factor - beta1 in a cultured stellate cell line.

In ligase deficient mice, growth of mouse melanoma cells in vivo is attenuated, while tumor infiltration by CD4 + / CD8 + T cells and dendritic cells is increased.

This is particularly important for vaccination against viruses and diseases such as cancer, in which T cells do not function strongly enough or fast enough to combat the growth of the virus or growth of the tumor cells.

This leads to regulatory T - cell development, subsequent interleukin (IL)-10 and transforming growth factor beta secretion, and ultimate suppression of the immune response.

In a xenograft KMT2D - mutated T - lymphoma model, dual treatment with chidamide and decitabine significantly retarded tumor growth and induced cell apoptosis through modulation of the KMT2D / H3K4me axis.

They showed that T cells in mice that could not make PSGL - 1 delayed tumor growth, suggesting that blocking PSGL - 1's function would help T cells fight tumors.

No leukemia growth was observed in mice receiving TCD - BM + spleen T cells, indicating a potent GVL effect, but these mice developed severe GVHD after transplantation (Fig. 5B — D).

T cells that specifically recognize cancer are isolated from the patient, stimulated with IL - 2 (a growth factor for T cells), expanded into billions of copies, and then replaced into the patient.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Sandoval F, Terme M, Nizard M, Badoual C, Bureau MF, Freyburger L, Clement O, Marcheteau E, Gey A, Fraisse G, Bouguin C, Merillon N, Dransart E, Tran T, Quintin - Colonna F, Autret G, Thiebaud M, Suleman F, Riffault S, Wu TC et al. (2013) Mucosal Imprinting of Vaccine - Induced CD8 + T Cells Is Crucial to Inhibit the Growth of Mucosal Tumors.

Tran T, De Oliveira Diniz M, Dransart E, Gey A, Merillon N, Lone YC, Godefroy S, Sibley C, Ferreira LC, Medioni J, Oudard S, Johannes * L, Tartour * E (2016) A therapeutic Her2 / neu vaccine targeting dendritic cells preferentially inhibits the growth of low Her2 / neu - expressing tumor in HLA - A2 transgenic mice.

In mouse models of both tumors, treatment with the fusion protein significantly slowed tumor growth and extended survival, probably through the activity of cytotoxic CD8 T cells.

Then, we systematically compared the effect of the hinge domains on the growth kinetics, cytokine production, and cytotoxicity of CAR T cells in vitro and in vivo.

Growth or function of different types of immune cells, like macrophages, neutrophils, natural killer cells, T cells, and B cells is impaired by zinc deficiency.

This mineral has been known to reduce inflammation, decrease tumor growth, and has the ability to stimulate the production of killer T - cells — which improves immune function in response to infections.

He also observed that dietary protein stimulated tumor growth, but that when restricted for a short period (6 - 12 weeks), the immune profile changed and the white T - cell count improved.

Key Benefits: ● Supports a Reduction of Intestinal Related Issues * ● Protects Against Irritations from Toxins * ● Promotes Epithelial Growth and Repair * ● Promotes T - cell Maturation * ● Balances the Immune System Naturally * ● Quickly Modulates / Balances the Body's Cytokine Panel * ● Restores Vital Immunity and Balance to the Intestinal Tract * ● Prevents Amyloid - B Peptide Aggregation *

«[T] he normal rate of cell proliferation would have been decreased during protein deprivation, which is similar to the retardation of brain cell growth of young malnourished animals.

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In addition, zinc deficiency reduces the secretion by T cells of interleukin - 4 (IL - 4), a growth factor for T - cell helpers (Dowd et al. 1986).

Thymic atrophy: a deficiency of cell - mediated immunity expressed by decreased T - cell function and low levels of growth hormone.

Cell - mediated immunodeficiency: a deficiency of t - lymphocyte function causing impaired immunity, chronic recurrent infections and stunted growth.

Surgery was performed to remove the growth and the biopsy revealed the diagnosis of T - cell lymphoma.