Sentences with phrase «t cell homeostasis»

The antiepileptic drug valproic acid restores T cell homeostasis and ameliorates pathogenesis of experimental autoimmune encephalomyelitis.

CRI Investigator Gabriel Rabinovich and his team identify a novel mechanism of T cell homeostasis based on differential glycosylation of T helper cell subsets.

While humanized mouse models for HIV infection have utility, the model is limited due to incomplete immune reconstitution, development of xenogeneic graft versus host disease (GVHD), and the absence of normal T cell homeostasis.

Not exact matches

One of these T cell subsets is comprised of the CD1d - reactive invariant natural killer T cells, and over the years we have studied the development, homeostasis, activation and regulation of function of these cells, as well as their specificity and the pathways leading to the processing and presentation of antigens by CD1d.

CD4 + regulatory T (Treg) cells expressing the forkhead box transcription factor Foxp3 have a vital function in the maintenance of immune homeostasis and the prevention of fatal multi-organ autoimmunity throughout life.

Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8 + T cells.

It was shown that VPA could induce the apoptosis of activated T cells and maintain immune homeostasis through the caspase - 8 / caspase - 3 pathway (28).

We conclude that gamma (c) cytokines (primarily but not exclusively IL - 7) provide Bcl -2-dependent as well as Bcl -2-independent signals to maintain the phenotype and homeostasis of the peripheral naive CD4 (+) T cell pool.

We then examined whether VPA regulated immune homeostasis and ameliorated GVHD through inducing apoptosis of CD4 + T cells in vivo.

CONCLUSION: A pronounced shift in peripheral T - cell homeostasis was observed in CAD patients.

T - cell responses to commensals might support intestinal homeostasis, by producing barrier - protective cytokines and providing a large pool of T cells that react to pathogens.

Adding healthy probiotics rich in Lactobacillaceae bacteria can exhibit anti-inflammatory effects by suppressing pro-inflammatory T cells and interleukins and stimulating Treg cells to regulate immune cell homeostasis.