Sentences with phrase «t cell immunity»

The most important changes occur in T cell immunity, manifested sometimes dramatically as altered clonal expansions of cells of limited antigen specificity and a marked shrinkage of the T cell antigen receptor repertoire.

The Babraham Institute wishes to recruit a highly motivated Postdoctoral Research Scientist to investigate molecular mechanisms by which T cell immunity is suppressed in cancer.

One is that there is no interaction between antibody - mediated immunity and T cell immunity (which we know is an oversimplification), and that the future universal vaccines do not actually protect against infection (this does seem a rather radical assumption).

TNFR / TNF family members in antiviral CD8 T cell immunity.

Costimulatory members of the TNFR family: Keys to Effective T cell immunity.

And when the dendritic cell migration was selectively blocked, it impaired either CD4 + or CD8 + T cell immunity from developing.

Reported in the January 16, 2015 issue of the journal Science, the new findings provide a cautionary tale for the development of vaccines aimed at eliciting robust CD4 T cell immunity against chronic infections, including HIV.

cruzi T cell immunity, and booster immunization would be an effective strategy to maintain or enhance the vaccine - induced protective immunity against T. cruzi infection and Chagas disease.»

Synthetic peptides corresponding to microbial epitopes stimulate T cell immunity but their immunogenicity is poor and their half - lives are short.

Not exact matches

These vitamins are responsible for a number of bodily functions that ward off winter illness, including the regulation of T cells (or immune system warriors) and counteracting stress hormones that lower immunity.

But Edwards was never convinced that T - cells were the alpha and omega of immunity.

Thus, this approach could prove useful to enhance the septic patient's T - cell - mediated immunity during the period of immunosuppression.

«In our latest study, results suggest that the combination of an OX40 agonist antibody and GSK2636771 may induce robust and durable antitumor T - cell immunity,» said Weiyi Peng, M.D., Ph.D., assistant professor of Melanoma Medical Oncology, and co-lead of the study.

Although changes in treatment methodology still have to be studied, Dr. Cripe believes it may be that the timing of various treatments is what matters, and that perhaps initially suppressing immunity could allow the virus to infect a large number of tumor cells before relieving the immunosuppression to allow the body's own T cells to fight off the tumor.

The vaccine harnesses the natural process of T - cell immunity to tumors, but enhances it to help overcome tumors» formidable defenses.

DCs are specialized immune cells that can ingest foreign antigens, degrade them and present the fragments on their surface to activate T cell - mediated immunity.

The powerful, durable protection conferred by the candidate vaccine is due in large part to its strong stimulation of CD4 helper T cells, which are important for maintaining long - term antibody immunity.

As with innate immunity, the adaptive immune system — the T cells and antibodies produced by B cells that target specific molecules on invading cells — contributes to pathology or may also fight against it.

Kipnis and his colleagues had previously shown that a type of white blood cell called a T cell (shown above) in the meninges is associated with significant influence on cognition and hence were curious about the role of meningeal immunity on brain function.

If the finding that resident memory T cells are the most potent mediators of immunity holds up in different types of cancer, which I think it will, you could take a biopsy of the lung or the pancreas, for example, to see if there are resident T cells there.

Simultaneously, a cell - mediated immunity system also becomes active, deploying cytotoxic T - cells to directly recognize and kill pathogen - infected cells.

«Dengue immunity can protect against Zika virus: Researchers reveal dual Zika / dengue immunity conferred by cytotoxic T - cells.»

Those mice became sick, recovered from infection, and hence acquired immunity to dengue, presumably because viral infection had mobilized their immune B - cells, T - cells or both.

«Recent successes in cancer immunotherapy — in the form of immune checkpoint inhibitors and adoptive T cell transfer — demonstrate how activated immune cells can eradicate tumors, but until now we didn't fully appreciate immunosurveillance or the role of adaptive immunity in tumor formation,» said senior author Michael Karin, PhD, Distinguished Professor of Pharmacology and Pathology at UC San Diego School of Medicine.

In additional experiments, the scientists found that participants who had significant antibody responses did not necessarily also have significant immune system T cell responses to avian viruses, indicating that these two arms of immunity can be independently boosted after vaccination or infection; that individuals who reported receiving seasonal influenza vaccination had significantly higher antibodies to the avian H4, H5, H6, and H8 subtypes; and that participants with exposure to poultry had significantly higher antibody responses to the H7 subtype, but to none of the other subtypes tested.

In order to achieve sustained protective immunity against AIDS, a vaccination strategy inducing a balanced immune response without an increase of CD4 + T helper cells must be developed (Journal of Virology).

In the previous research, they studied adaptive immunity, specifically the impact of T cells on chemoresistance.

Adaptive immunity is mediated by T cell signaling.

In a mouse model of type 1 diabetes, RGS1 affects the population of one type of T cell called a «T follicular helper cell» that is critical for B cells and antibody production, Dr. Kissler and his colleagues reported recently in Genes and Immunity.

«Key to improved cancer immunotherapy: Study demonstrates that tissue - resident and circulating memory T cells cooperate in anti-tumor immunity.»

Significant advances also have been made in understanding T - cell responses that may be important to vaccine - induced immunity against HIV.

Immunity is key to long - term responses Knowing that the immune system is capable of recognizing distinctive features of cancer cells and launching a T cell attack against those tumor antigens, and that checkpoint blockade removes a roadblock to that attack, it's logical that these drugs should work against many tumor types.

Published Thursday January 21st, 2016 in the journal Cell Reports, a team from Cardiff University's Systems Immunity Research Institute identify a molecule in the body — known as L - selectin — which directs the body's killer T cells to the site of a virus.

«There is wide variation in the strength of T - cell immunity when people are first infected with the virus, ranging from very strong and sustained to none,» notes Dr. Walker, who also is a professor of pediatrics and molecular virology, immunology, and medical genetics at The Ohio State University.

Specifically, they want to know what role the quality of T - cell immunity before treatment plays in therapeutic response.

«The anti-tumor immune response with CDK4 / 6 inhibition was somewhat unexpected — some had previously thought that CDK4 / 6 inhibitors would block anti-tumor immunity, due to effects on T cell proliferation, but our findings demonstrate quite the opposite,» DeCristo states.

Reference: Immunity, «The PIAS - like coactivator Zmiz1 is a direct and selective cofactor of Nortch1 in T - cell development and leukemia,» published online Oct. 27

Research Interests: Tumor immunity, T lymphocyte effectors, immunotherapy, T - cell dysfunction in cancer, myeloid derived suppressor cells (MDSC) and angiogenesis

CD1 - restricted T cells are abundant, recognize bacterial - derived or cell - endogenous lipids, and are implicated in the control of infections, cancer and auto - immunity.

By showing that ligands associated with innate immunity enable dendritic cells to initiate T cell responses, this work provided the key missing link between the innate and adaptive immune responses.

The capacity of DC to induce peripheral tolerance is a potential mechanism by which MSC could manipulate immunity in order to escape T cell recognition.

Prof. Sarah Gilbert: I am the author of a patent on an influenza vaccine to induce broad immunity through T cell responses

Split T - cell tolerance in herpes simplex virus - infected mice and its implication for anti-viral immunity.

Using an assortment of engineered and non-engineered mice, the researchers looked specifically at the role of T cells (white blood cells that play a key role in immunity).

TIM - 4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen - specific T cells.

The common characteristic of all types of SCID is absence of T - cell - mediated cellular immunity due to a defect in T - cell development.

The American Society of Transplantation (AST) Symposium New Paradigms in T Follicular Cell Biology and Transplant Immunity Saturday, May 5, 12:30 PM — 2:30 PM, Room 16AB Chairs: Peter Heeger, Ichan Sch.

One avenue of our translational research aims to determine the impact of in utero HIV - 1 exposure on infant immunity to vaccinations and co-infections by dissecting the infant immune repertoire present at birth in the context of maternal HIV - 1 infection and how the infant T cell repertoire changes following early life exposures compared to infants born to the HIV - 1 uninfected women of similar socio - economic status.

T cells deficient in diacylglycerol kinase zeta are resistant to PD - 1 inhibition and help create persistent host immunity to leukemia.

Memory CD8 T cell responses exceeding a large but definable threshold provide long - term immunity to malaria.