Sentences with phrase «t cell infiltration»

PEGylated arginine deiminase can modulate tumor immune microenvironment by affecting immune checkpoint expression, decreasing regulatory T cell accumulation and inducing tumor T cell infiltration.

«This is the first identified cell - intrinsic cancer - causing pathway that disrupts T cell infiltration in melanoma,» said study author Thomas Gajewski, MD, PhD, professor of medicine and pathology at the University of Chicago.

Not exact matches

Further investigations showed that the mutation causes reduced CTLA - 4 function, which led to increased infiltration of the intestinal mucosa by T - cells and therefore to chronic diarrhea.

«Injecting the human blood cells resulted in massive liver cell damage and we were able to detect cytotoxic T lymphocytes that specifically targeted hepatitis B virus in liver infiltration cells.

«In this study we found that NF - κB activity is strongly associated with immune system T - cell infiltration in lung cancer,» explained study co-author Dung - Tsa Chen, Ph.D., member of the Biostatistics Department at Moffitt.

Schneck says some scientists have emphasized that response to immunotherapy is largely dependent on whether T - cells are infiltrating the tumor site, but his research suggests that while, «infiltration is important, it's not enough to explain patients» variable responses to immunotherapy drugs.»

Blame for treatment failures is usually attributed to so - called «cold» tumors, those that do not attract T - cell infiltration and may lack key T - cell targets — the mutated proteins known as neoantigens.

ADCC / ADCP - enabling isotypes of a-TIGIT surrogate Ab show potent monotherapy efficacy in murine tumor models that correlates to increased T cell activation and reduced Treg infiltration of tumors.

In ligase deficient mice, growth of mouse melanoma cells in vivo is attenuated, while tumor infiltration by CD4 + / CD8 + T cells and dendritic cells is increased.

Moreover, the increase in leukocyte infiltration is most striking when considering the total numbers of CD4 and CD8 T cells, providing further evidence for a T cell - mediated immune response in the brain and / or meninges following infection with attenuated Type I parasites (Figure 3F).

Increased T - cell Infiltration Elicited by Erk5 Deletion in a Pten - Deficient Mouse Model of Prostate Carcinogenesis.