Sentences with phrase «t cell lineage»

The most compelling argument for an inflammatory role has come from studies of transgenic mice that over express LIGHT in the T cell lineage.

Not exact matches

In this process, several hundred times more cells of the so - called myeloid lineage (thrombocytes, erythrocytes, granulocytes, monocytes) form than long - lived lymphocytes (T cells, B cells, natural killer cells) do.

These findings suggested that exhausted T cells are a distinct lineage of T cells in and of themselves instead of just being effector or memory T cells restrained by checkpoint pathways.

The discovery that lineage - related melanoma antigens can be recognized by patients» T cells then opened the way to their use in melanoma immunotherapy.

Hematopoietic Lineage Cell - Specific Protein 1 Is Recruited to the Immunological Synapse by IL -2-Inducible T Cell Kinase and Regulates Phospholipase Cγ1 Microcluster Dynamics during T Cell Spreading.

Maria Rostovskaya (Stewart, TUD)-- «Lineage commitment of conditionally immortalized bone marrow mesenchymal stromal cells from tetracycline - regulated SV40 large t - antigen transgenic mice» (2010)

Recently, interest has developed regarding the possibility of targeting intracellular inhibitory proteins to improve T cell activity against cancer, including diacylglycerol kinase ζ (DGKζ)(9, 10) and Casitas b - lineage proto - oncogene b (Cbl - b)(11), which attenuate signal transduction events downstream of the TCR and CD28.

Title: Inferring rules of lineage commitment in haematopoiesis Authors: Pina C, Fugazza C, Tipping AJ, Brown J, Soneji S, Teles J, Peterson C, Enver T Date: 2012 Publication Details: Nature Cell Biology 2012 Feb 19; 14 (3): 287 - 294

Anaplastic large cell lymphoma (ALCL) is an aggressive form of malignant lymphoma of T / null lineage (1).

We did not identify the JAK2V617F disease allele in B - lineage ALL (n = 83), T - cell ALL (n = 93), or CLL (n = 45).

Quantitative PCR analysis was performed to compare transcript levels of Venus with PrEn (Hex, Gata4, Gata6, Dab2, Sox7, Hnf4α, and Pdgfrα), pluripotency (Nanog, Klf4, Rex1, Stella, and Pou5f1) and other lineage (T, Fgf5, Eomes, Flk1, Mixl1, Cdx2, Sox1, Pax6, and Six3) markers in purified cell fractions.

In contrast, we did not identify JAK2V617F mutations in B - lineage ALL (83 patients), T - cell ALL (93 patients), or CLL (45 patients).

In this report, we identified JAK2V617F mutations in a subset of CMML / aCML, AML, and MDS but not in B - lineage ALL, T - cell ALL, or CLL.

He has been a leader in applying molecular and genetics tools to study the immune system including specification of T lymphocyte lineages, the differentiation of inflammatory T helper cells, the role of microbiota in regulating immune responses, and the mechanisms of HIV entry and pathogenesis.

We used direct sequence analysis to determine if the JAK2V617F mutation was present in acute myeloid leukemia (AML), chronic myelomonocytic leukemia (CMML) / atypical chronic myelogenous leukemia (aCML), myelodysplastic syndrome (MDS), B - lineage acute lymphoblastic leukemia (ALL), T - cell ALL, and chronic lymphocytic leukemia (CLL).

CpG stimulation of precursor B lineage acute lymphoblastic leukemia induces a distinct change in costimulatory molecule expression and shifts allogeneic T cells towards a Th1 response.

Although, remarkable progress has been made in the in vitro development of T cells from ES cells [6], [7], this has not been the case for other hematopoietic cell lineages.

While this approach did not allow us to examine the impact of selective EBI2 - deficiency in DCs on WT B - lineage cells, the experiment did allow assessment of the response of EBI2 - deficient B cells in mice that lack EBI2 on CD11c + DCs while retaining EBI2 on approximately half of all non-CD11c expressing cells (such as helper T cells).