CRK proteins selectively regulate
T cell migration into inflamed tissues.
The T cell migration halted again when the team added a chemical that blocks the IGF - 1 receptor, the authors report 23 August in the Journal of Immunology.
Researchers already knew that
T cell migration is triggered by chemical messengers called chemokines.
To see if the same chain of events happens in rheumatoid arthritis, Smith's team tested whether various kinds of fibroblasts would spur
T cell migration in test tubes.
Not exact matches
When in the light zone, B
cells are selected by follicular helper
T (TFH)
cells for
migration to the dark zone.
And when the dendritic
cell migration was selectively blocked, it impaired either CD4 + or CD8 +
T cell immunity from developing.
HIV - 1 triggers WAVE2 phosphorylation in primary CD4
T cells and macrophages, mediating Arp2 / 3 - dependent nuclear
migration.
A study has shown that the immunosuppressive effect of MSCs is mediated by the secretion of galectin - 3, a protein known to modulate
T cell proliferation, gene expression,
cell adhesion and
migration 44.
Endothelial
cell - derived GABA signaling modulates neuronal migration and postnatal behavior Li S, Kumar T P, Joshee S, Kirschstein T, Subburaju S, Khalili JS, Kloepper J, Du C, Elkhal A, Szabó G, Jain RK, Köhling R, Vasudevan A. Cell Resea
cell - derived GABA signaling modulates neuronal
migration and postnatal behavior Li S, Kumar
T P, Joshee S, Kirschstein
T, Subburaju S, Khalili JS, Kloepper J, Du C, Elkhal A, Szabó G, Jain RK, Köhling R, Vasudevan A.
Cell Resea
Cell Research.
Dendritic
cells (DC) are potent antigen - presenting
cells that are important for the induction of the primary immune response, including induction of
T cell responses,
migration, or antigen capture.
We conclude that the presence of
T cells is not required for the differentiation and
migration of resident skin DC but is critical for the maintenance of DC and LC migrating into the LNs.
These age - related defects were not due to defects in
migration of the aged CD4
T cells, but may be attributable to reduced CD154 (CD40L) expression.
The paper, co-authored by BSI member Dr Madhav Kishore and published in Immunity, reports that modulating regulatory
T cell metabolism can cause their increased
migration into tissues.
In vitro
migration assay showed that the hinges enhanced CAR
T cells migratory capacity.
In contrast, LPA treatment did not enhance the
migration of Lpar2 - / -
T cells toward CCL21.
We described the results in the third paragraph of the subsection «LPA enhances
T -
cell migration across narrow pores in an LPA2 / Rho - dependent manner».
After eGFP - expressing CD4 +
T cells and WT counterparts were treated with vehicle and indicated inhibitors, respectively, they were mixed with the collagen gel and monitored for
cell migration.
(A — D) Analysis of the intranodal
migration of WT and Lpar2 - / - CD4 +
T cells in the PLN of WT mice by intravital two - photon microscopy.
Intranodal
T -
cell migration in Enpp2fl / fl mice and Ccl19 - Cre Enpp2fl / fl mice, analyzed by intravital two - photon microscopy.
Dendritic
cells home to pancreatic and mesenteric lymph nodes and present gliadin, leading to «
migration of CD4 − CD8 − γδ and CD4 − CD8 + αβ
T cells to the target organ (gut and / or pancreas) where they cause inflammation» (Fasano, 2011).