Sentences with phrase «t cell populations»

The lack of increase in T cell populations in dogs with nKCS strongly suggests that the changes in iKCS are causing the tear deficiency and not resulting from it.

Due to extensive heterogeneity and multiple overlapping transcriptional programs in differentiating T cell populations, this process has remained a challenge for systematic dissection in vivo .

This is particularly true in the case of persistent herpesviruses such as human CMV, which are typified by large virus - specific CD8 + T cell populations during viral latency.

This novel pattern of a virus - specific CD8 + T cell response suggests that continuous or repetitive exposure to Ag can slowly mold memory T cell populations over time.

Janbazian L, Price DA, Canderan G, Filali - Mouhim A, Asher TE, Ambrozak DR, Scheinberg P, Boulassel MR, Routy JP, Koup RA, Douek DC, Sekaly RP, Trautmann L. Clonotype and repertoire changes drive the functional improvement of HIV - specific CD8 T cell populations under conditions of limited antigenic stimulation.

This may be relevant for understanding the evolution of the large human CMV - specific CD8 + T cell populations seen in humans.

PCR assays are routinely used for the identification of clonal B and T cell populations.

We present an in - depth characterization of human T cell populations using a panel of ~ 80 antibodies revealing complexity not previously observed by scRNA - seq alone.

The DKFZ researchers conducted this study in collaboration with Epiontis, a Berlin - based company that specializes in the epigenetic tests that were used to determine the ratio of the various T cell populations.

So I [thought], I know a little bit of immunology, I know a little bit of engineering, and I really want to talk about developing systems that can modulate antigen presentation or expand T cell populations in a specific direction.

Along with steroids, the mainstay of GVHD treatment today is drugs that turn down the production of IL - 2, a cytokine that helps T cell populations expand and diversify.

By varying the compositions of lipids, cues, and diffusible factors in the scaffolds, we engineered a very versatile and flexible platform that can be used to amplify specific T cell populations from blood samples, and that could be deployed in existing therapies such as CAR - T cell therapies,» said Mooney, Ph.D., a Core Faculty member at the Wyss Institute and leader of its Immunomaterials Platform.

This was good proof that gp96 is needed to maintain the proper balance of T cell populations, but Liu and her group wanted to connect that finding to a biological function relevant to humans.

In that paper, Weitzmann, Ofotokun, and their colleagues described bone loss similar to that observed in humans following the reconstitution of the T cell population in immune - compromised mice (similar to T - cell expansion following ART).

To identify this T cell population, the researchers took biopsies at the sites of active lesions before treatment and biopsies of the same skin areas after the lesions had cleared on therapy.

Now that they have identified the long lived, skin resident T cell population that appears to be driving recurrence, the team plans to search for new therapies that can deplete these resident T cells, potentially driving the disease into long term remission.

The difference between these two primates is that the sooty mangabey experiences only low levels of immune activation, which presumably limits the T cell population crash and viral replication.

Antibodies stimulate the recruitment of additional immune cells that help to activate T cells; the vaccine stimulates proliferation of T cells that can attack the tumor; IL - 2 helps the T cell population to expand quickly; and the anti-PD1 molecule helps T cells stay active longer.

The activated CD4 + T cell population also helps the virus replicate.

Scientists are not exactly sure how HIV causes the CD4 + T cell population to activate and crash.

The present findings are derived from studies using CD4KO mice and thus, raise the question as to whether the CD4 + T cell - independent immune mechanisms in CD4 KO mice differ from those involved in corneal allograft rejection in wild - type mice whose CD4 + T cells population have been depleted with monoclonal antibodies.

IL -35-mediated induction of a potent regulatory T cell population.

Inventors at MUSC have identified a unique human CD4 + T cell population that expresses high levels of surface CD26, termed CD26high T cells, which mediate durable antitumor immunity in vivo, and have immediate clinical relevance for designing new vaccines and cellular therapies.

Anti-viral therapies, such as the HAART regimen (Highly Active Antiretroviral Therapy), allow the T cell population a chance to recover and resume normal function.

In this study, we show that in elderly individuals seropositivity for human CMV leads to the development of oligoclonal populations of CMV - specific CTL that can constitute up to one - quarter of the total CD8 T cell population.

This is the first description of a human memory T cell population that is susceptible to being lost through end - stage differentiation due to the combined effects of lifelong virus reactivation in the presence of bystander differentiation - inducing factors.

The increase in the T cell population was highly statistically significant (p = 0.0025) while the increase in B cells, while statistically significant was less pronouncedly so (p = 0.049).

Not exact matches

They discovered a population of NKT cells that have a gene that controls so - called regulatory T - cells, whose role is to suppress the immune response.

That shift can lead to «an environment that is conducive to T - cell replication that results in amplification of subsets of viral populations and creation of genetically distinct, compartmentalized viral populations,» they explained.

They demonstrated that non-obese diabetic (NOD) mice treated with a specific (AID / RAD51) pathway inhibitor had larger populations of certain B cells that were capable of suppressing diabetogenic T cell responses, and greatly reduced T1D development, compared with untreated controls.

With treatment, T - cell subtypes normally associated with allergic responses diminished, while a novel T - cell population that likely would not mount an allergic response expanded.

Oral immunotherapy for peanut allergy induces early, distinct changes in immune T - cell populations that potentially may help researchers determine which people will respond well to the therapy and which immune mechanisms are involved in the response, a new study suggests.

Now, a team of scientists at the Icahn School of Medicine at Mount Sinai have developed the Just EGFP Death - Inducing T - cell, or JEDI T - cells, which enable the visualization of T - cell antigens, allowing researchers to study T - cell interactions with different cell types, model disease states, and finally determine the functions of otherwise poorly characterized cell populations.

By using these and other high - tech tools, the researchers homed in on a unique population of T - cells that are highly prevalent in the joints of rheumatoid arthritis patients.

Participants with high - risk bacterial communities, which are commonly found in the population of women studied, also had increased numbers of genital CD4 + T cells — white blood cells that are HIV's primary target.

«Uncovering why psoriasis recurs: Study identifies population of resident T cells that may initiate psoriasis and allow skin lesions to recur after therapy ends.»

The population of T cells that remains are tissue resident memory cells, which live long term in skin and, when functioning properly, should be fighting infection.

It's been challenging to zoom in on the population of T cells driving the disease in part because when psoriasis is active, lesions are flooded with diverse T cells.

«Scientists identify a new population of regulatory T - cells.»

She said that a failure to maintain NFkB signals at this point, or even after memory T cells have been produced, leads to a loss of the population of memory T cells that have been generated after the infection.

Separately, the high levels of a type of T cell called Th17 cells secrete gobs of interleukin - 17 (IL - 17), expanding macrophage populations.

The percentage of malignant T cells was reduced significantly in nine of ten tested participants, three of whom had complete eradication of the malignant population, and one of whom had a 99.6 percent reduction.

That alters gut microbe populations, triggering the activity of pro-inflammatory T cells, which cause further damage in the brain, mouse studies show.

In a mouse model of type 1 diabetes, RGS1 affects the population of one type of T cell called a «T follicular helper cell» that is critical for B cells and antibody production, Dr. Kissler and his colleagues reported recently in Genes and Immunity.

To develop new, targeted treatments to eliminate these residual infected cells, we need to find exactly where in the CD4 T lymphocyte population the virus hides.

Student's t tests excluding the outlier indicated a p - value of < 0.04 for the remaining five pandemic H1N1 samples compared with the IgG memory and germinal center (GC) cells or the primary IgG plasmablast responses (0.2 with EM included) and a p - value of < 0.0001 against the IgM populations.

Enhanced expression of one of these molecules, CD1d, is coupled to selective induction of invariant natural - killer T cells (iNKT), a subset of T lymphocytes that are present at low levels in lymphocyte populations and whose absence enhances autoimmunity in animal models.

Vα14 invariant NKT (Vα14 iNKT) cells are a population of T lymphocytes that have several unique characteristics; many of these are related to their ability to function similarly to cells of the innate as opposed to the adaptive immune system.

We have discovered a T cell sub population whose specificity is conserved between species characterized by the use of an invariant chain, the Vα7.2 / 19 - Jα33 TCRα chain.

The capacity of CD8 + T cells to mediate corneal allograft rejection could have been due to the CTL population that might have been present in the CD8 + T cell suspensions used in the adoptive transfer inocula.