Sentences with phrase «t cell products»

Dozens of trials are underway, and two CAR - T cell products, for childhood and young adult ALL and aggressive B - cell lymphoma, may be approved later this year by the U.S. Food and Drug Administration (FDA).

At the National Cancer Institute in Bethesda, Maryland, hematologist James Kochenderfer's waiting list is driven by the two or three CAR - T cell products a month he's able to secure from the agency's facility.

Not exact matches

CAR - T treatments, including competing products from Novartis rivals Kite Pharma and Juno Therapeutics, come with the risk of potentially deadly side effects such as cytokine - release syndrome (CRS), in which a glut of T - cell - assisting cytokines can cause high fever, low blood pressure, and problems with lung oxygenation.

Juno asserted that the clinical hold on the ROCKET trial did not affect plans for its other CD19 - directed CAR T - cell product candidates, including JCAR017, for which the company has launched two clinical trials now recruiting patients.

JCAR015 is a CD19 - directed chimeric antigen receptor technology (CAR - T) product candidate that has been under study in ROCKET in adult patients with relapsed or refractory B - cell acute lymphoblastic leukemia.

At this time, trials and plans for its other CD19 - directed chimeric antigen receptor (CAR) T - cell product candidates, including JCAR017, are not affected.

Using polymerase chain reaction methods that amplify DNA and Jones» assay that detects by - products of ALDH, the Johns Hopkins team found that regulatory T - cells express high levels of ALDH.

Human cells infected by the viruses produced the gene products, giving T cells an advance exposure to them.

Researchers, physicians and patients need T cell - based products that can respond to malignant or infected cells that may reappear months or years after treatment.

If CTL019 is approved, the Swiss pharmaceutical giant plans to dole it out from about 30 preapproved sites, each trained in the multi-step process of harvesting cells, handling the product, and treating patients for the feverish and often life - threatening immune response that usually accompanies CAR - T therapy.

CD74 is broken into products that fit into the groove of cell surface immune response proteins as part of the chain of events that activates T cells — immune cells that normally attack infected (or damaged) cells in the body.

The protein products of these genes, the authors note, «represent targets for immunotherapy, because inactivating mutations sensitize tumor cells to T - cell mediated attack.»

Poseida Announces Initial Phase 1 Data for P - BCMA - 101 CAR - T Stem Cell Memory Product in Patients with Relapsed / Refractory Multiple Myeloma

on Poseida Announces Initial Phase 1 Data for P - BCMA - 101 CAR - T Stem Cell Memory Product in Patients with Relapsed / Refractory Multiple Myeloma

Precious patient samples, contamination concerns, and limited product purification options have compelled manufacturers of cellular immunotherapies (iTx) such as chimeric antigen receptor T cells (CAR - T) and T - cell receptor (TCR) technologies toward the disposables industry.

After detecting microbial products or pro-inflammatory cytokines, immature dendritic cells transform into mature dendritic cells, which exhibit an exceptional capacity for T cell activation.

Fusion product of human B cell line 721.174 and human T cell line CEM.

Complement activation products not only directly help to eliminate invading pathogens, but also participate in many immunological reactions, including clearance of immune complexes, antibody production, and T - cell regulation.

Under his direction, plasmid DNA, CAR - T - cells, regulatory T - cells, engineered stem cell grafts and gene modified hematopoietic stem cell products have been manufactured and released for use in Phase I / II clinical trials.

Additionally, the drug was shown to inhibit the TRAF2 - and NCK - interacting kinase (TNIK), a regulatory component of the β - catenin and T - cell factor - 4 (TCF - 4) transcriptional complex downstream of the adenomatous polyposis coli (APC) gene product in colon cancer [30].

With our anti-TIGIT antibody program, we saw anti-tumor efficacy and reactivation of T - cells in preclinical models which is encouraging for the potential of this product as a monotherapy

Invivoscribe offers a full range of hematology - oncology testing products and services (B - and T - cell clonality, NGS gene panels, MRD assays, and comprehensive bioinformatics software), all developed under ISO 13485 design control and manufactured in our own cGMP facility.

Our product candidates are also intended to combine with other mechanisms of action across the oncology landscape, such as checkpoint inhibitors or engineered T cells, to increase the benefit to patients and potentially place Immune Design at a central place in the treatment paradigm.

The team provided the most comprehensive data yet on cytokine release syndrome, neurological toxicities and infections after infusion of a CAR T - cell product, laying the groundwork for reducing the risk of the most severe toxic effects.

Invivoscribe products identify clonal rearrangements within the immunoglobulin and T - cell receptor genes, which helps identify clonal B - and T - cell populations.

Plus, Dr. John Douillard points to research that people who eat gluten - free products have 400 percent more mercury toxicity than wheat eaters, and are deficient in killer T cells.

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Work in administration and manufacturing or processing of cell therapy products such as TIL, CAR - T cells, and stem cell or blood product transplants.