Barnett JB, Dao MC, Hamer DH, et al: Effect of Zinc Supplementation on Serum Zinc Concentration and
T Cell Proliferation in Nursing Home Elderly: A Randomized, Double - Blind, Placebo - Controlled Trial.
Surprisingly, there was no difference between our tolerant and control animals in the degree of
T cell proliferation (data not shown).
Balb / c splenocytes were used as third - party responder cells assuming that these would induce the same degree of
T cell proliferation in tolerant and control animals.
IL - 7 driven
T cell proliferation is refractory to most of immunosuppressive compounds.
Enhanced disease is associated with altered cytokine production and
T cell proliferation.
Krampera et al 90 confirmed these findings, they showed that murine MSC lack MHC class II and inhibited
T cell proliferation.
MSCs impair the differentiation of monocytes or CD34 + HSCs into DCs by inhibiting the response of the former to maturation signals, reducing the expression of co-stimulatory molecules and hampering the ability of the former to stimulate naive
T cell proliferation and IL - 12 secretion 33, 34, 35.
A study has shown that the immunosuppressive effect of MSCs is mediated by the secretion of galectin - 3, a protein known to modulate
T cell proliferation, gene expression, cell adhesion and migration 44.
Deletion of DGKζ from T cells results in prolonged TCR signal transduction downstream of DAG, resulting in enhanced activation of Ras, increased effector
T cell proliferation, and amplified cytokine production, which leads to increased antitumor activity against s.c. implanted EL4 tumors or murine mesothelioma (12, 16, 17).
This supported work from Bartholomew et al 120 showing that the addition of IL - 2 to MLR / MSC co-cultures reduced MSC suppression and restored
T cell proliferation.
Zhidan Tu, Yan Li, Dawn Smith, Nader Sheibani, Suber Huang, Timothy Kern and Feng Lin (2011): Retinal pericytes inhibit activated
T cell proliferation Invest Ophthalmol Vis Sci.
Naive CD4
t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression.
«The anti-tumor immune response with CDK4 / 6 inhibition was somewhat unexpected — some had previously thought that CDK4 / 6 inhibitors would block anti-tumor immunity, due to effects on
T cell proliferation, but our findings demonstrate quite the opposite,» DeCristo states.
Notably, the presence of ADA produced an increase in CD4 + responder T cells, in CD8 +
T cell proliferation and in T cell memory generation.
In March 2016, Penn researchers published a study in Blood that showed long - term ibrutinib treatment reverses the dysfunction of T cells in CLL and that combining CAR therapy with ibrutinib enhanced engineered
T cell proliferation in mice.
Not exact matches
Unlike the differential effect on Treg
cell proliferation following PD - L1 blockage, the researchers observed an increase in the
proliferation of killer
T cells from all HIV study groups, regardless of their viral load.
In their models, abatacept reduced the
proliferation and activation of effector
T cells.
Created with other blood
cells in the bone marrow, they interfere with activation and
proliferation of
T cells, the immune system's attack
cells.
They found substantial differences following influenza vaccination in the production of immune - modulators that determine the type of
T -
cell response and in the
proliferation and production of antibodies by B
cells.
Using mice deficient in Del - 1, they found that the protein promotes
proliferation and differentiation of hematopoetic stem
cells, sending more of these progenitor
cells down a path toward becoming myeloid
cells, such as macrophages and neutrophils, rather than lymphocytes, such as
T cells and B
cells.
A recent paper in the experimental biology publication The FASEB Journal describes how peptides found in hookworms inhibit the
proliferation of effector memory
T cells, which, unlike regulatory
T cells, can actually trigger inflammation.
Antibodies stimulate the recruitment of additional immune
cells that help to activate
T cells; the vaccine stimulates
proliferation of
T cells that can attack the tumor; IL - 2 helps the
T cell population to expand quickly; and the anti-PD1 molecule helps
T cells stay active longer.
The degree of lymphocyte
proliferation, regulatory
T -
cell generation and cytokine secretion were measured.
Most significantly, the activated
T cells — the soldiers that fight germs — not only produce large amounts of cytokines (chemical messengers that help to coordinate a counterattack) but also enter the
cell cycle, a process that normally leads to
cell division and
proliferation.
Dendritic
cells usually send out signals that ramp up
proliferation of another type of immune
cell,
T cells, which then attack invaders.
In
cell cultures and in mice LPA prevented signaling within
cells, the appearance of molecules associated with
T -
cell activation, and
proliferation of the
T cells.
Human adipose tissue - derived mesenchymal stem
cells induce explosive
T -
cell proliferation.
Sioud M, Mobergslien A, Boudabous A, Fløisand Y. Evidence for the involvement of galectin - 3 in mesenchymal stem
cell suppression of allogeneic
T -
cell proliferation.
More specifically, we found that
T cells from DGKζ − / − and Cbl - b − / − mice exhibit similar levels of enhanced
proliferation at low levels of TCR stimulation.
Hsiou - Chi Liou and colleagues find that c - Rel, a lymphoid - specific member of the NF - kappaB / Rel family of transcriptional factors, is essential for B lymphocyte survival and
cell cycle progression, [i] and that it is important for inducible cytokine and cytokine receptor expression and a key regulator of early activation and
proliferation in
T cells.
The addition of IL - 2, as expected, enhanced the
proliferation of WT
T cells, but not completely to levels observed with DGKζ − / − CD8 +
T cells + IL - 2 or to Cbl - b − / − and DKO CD8 +
T cells (Fig. 3D).
Previous work with DGKζ − / − CD8 +
T cells showed that increased TCR - mediated
proliferation relative to WT
T cells can be largely attributed to increased IL - 2 production (17, 25).
Suppression of allogeneic
T -
cell proliferation by human marrow stromal
cells: implications in transplantation.
This alteration likely can be attributed to a combination of decreased persistence of memory
T cells (41) and enhanced homeostatic
proliferation resulting from increased strength of signal downstream of the TCR (16).
For (D)--(F), 5 × 104 Stemcell Technologies — purified naive CD8 +
T cells were incubated with 0.3 μg / ml anti-CD3 Ab at 37 °C for 72 h. Cells were surface - stained for viability and evaluated for proliferation as assessed by dilution of CFSE within CD8 + - gated cells
cells were incubated with 0.3 μg / ml anti-CD3 Ab at 37 °C for 72 h.
Cells were surface - stained for viability and evaluated for proliferation as assessed by dilution of CFSE within CD8 + - gated cells
Cells were surface - stained for viability and evaluated for
proliferation as assessed by dilution of CFSE within CD8 + - gated
cellscells (D).
Mesenchymal stromal
cells promote or suppress the
proliferation of
T lymphocytes from cord blood and peripheral blood: the importance of low
cell ratio and role of interleukin - 6.
In contrast,
proliferation differences seen between DGKζ − / − or Cbl - b − / − CD8 +
T cells mostly dissipate upon administration of exogenous IL - 2, which indicates that the enhanced production of IL - 2 in stimulated Cbl - b − / − CD8 +
T cells is the primary factor responsible for the observed differences between the two genotypes.
The elevated incidence of glomerulonephritis in p21 - deficient mice, with increased severity among females, has been reported previously (35) and is attributable to an autoimmune process produced by abnormal
proliferation of memory
T -
cell lymphocytes.
Merkel
Cell Polyomavirus Large
T Antigen Disrupts Host Genomic Integrity and Inhibits Cellular
Proliferation.
Di Nicola et al 127 showed that MSC strongly suppressed CD4 + (and CD8 +)
T cells in MLR findings supported by Tse et al 128, who showed that MSC suppress the
proliferation of
T -
cell subsets.
Deletion of DGKζ or Cbl - b comparably enhanced CD8 +
T cell functional responses, such as
proliferation, production of IFN - γ, and generation of granzyme B when compared with wild type
T cells.
Initial studies demonstrated that ligation of 4 - 1BB on
T cells could deliver costimulatory signals resulting in either increased
proliferation or enhanced cytokine secretion and also control clonal expansion and differentiation of effector and memory
T cells.
The most over-expressed gene in adipose tissue of diabetic co-twins was SPP1 encoding the inflammatory cytokine osteopontin, which recruits macrophages into adipose tissue and stimulates
T -
cell proliferation during inflammation (34).
In 2002, his group was the first to report the design of «second - generation» CARs that, in addition to a binding domain outside of the
T cell and a signaling domain inside, included a costimulatory domain designed to promote
cell proliferation and survival.
Proliferation of latently infected CD4 +
T cells carrying replication - competent HIV - 1: Potential role in latent reservoir dynamics.
Our older data had shown that the molecules B7 and ICAM could costimulate naïve
T cell activation when expressed in isolation, but an efficient response, including high levels of CD40L, IL - 2, and short - term
proliferation, resulted only when both B7 and ICAM were able to signal through CD28 and LFA - 1 at the same time (Dubey, 1995, J Immunol; Jaiswal, 1996, Int Immunol; Rogers, 1998, J Immunol).
Functionally,
T cells stimulated by antigen but without costimulatory signals, are able to proliferate and expand in numbers, but only transiently, with
proliferation being very short - lived and few
T cells being able to survive over time (Rogers, 1998, J Immunol).
CD8 (+)
T cells that undergo extensive rounds of antigen - driven
proliferation in
cell culture invariably reach the end stage of replicative senescence, characterized by irreversible
cell - cycle arrest and a critically short telomere length.
Repeated antigenic encounter drives
proliferation and differentiation of memory
T cell pools.
Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal
T lymphocytes, with deregulation of genes involved in apoptosis,
proliferation,
cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 /
T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5