Sentences with phrase «t cell recognition»

Lloyd Old, Thierry Boon, and colleagues develop the TNF release assay for mouse systems in which release of TNF by T cells could be used to assess specific T cell recognition, facilitating the cloning of human tumor antigens.

The capacity of DC to induce peripheral tolerance is a potential mechanism by which MSC could manipulate immunity in order to escape T cell recognition.

CRI presents the Coley Award to Thierry Boon, for the isolation of genes responsible for mutation - induced production of cancer antigens by T cells, and to Rolf M. Zinkernagel, for landmark discoveries about MHC restriction of T cell recognition.

Not exact matches

The tools included TCRdist, which researchers used to calculate the similarity and differences of key features of T cell receptors, such as amino acid sequences in important regions for antigen recognition.

Antigens are exposed on the surface of DCs in a protein complex along with major histocompatibility complex (MHC) proteins that mediate the recognition and activation of the appropriate T cell subtype.

This seminal finding led to his recognition as an important scientist in vaccine design, and to his inclusion as a T cell expert in the CHAVI - ID vaccine consortium.

Since T cells can only recognize neoantigens that are «presented» to them by HLA molecules of the immune system, a key step in making the vaccine is using computer algorithms to predict which neoantigen peptides will bind strongly to the HLA molecules for recognition by T cells.

Zelig Eshhar and colleagues first use the T - body approach, employing chimeric receptors composed of an antibody recognition unit linked to T cell activation domains, to redirect T cells to recognize and attack tumor cells.

«We have experiments in mice that show that the combined use of PD - 1 antibody and poly - IC is synergistic for the recognition of tumors and an antitumor response mediated by T - cells,» says Dr. Esteban Celis, co-leader of the Cancer Immunology, Inflammation and Tolerance program at the Georgia Cancer Center at Augusta University.

Group 1 CD1 - restricted T cells and the pathophysiological implications of self - lipid antigen recognition.

On the flip side, improper recognition of self - antigens by T cells is the primary cause of most autoimmune diseases.

Self - recognition of the endothelium enables regulatory T - cell trafficking and defines the kinetics of immune regulation.

To improve CAR - T tumour recognition, some researchers are adding a second CAR, so that the engineered cell has to recognise two antigens before mounting an attack.

Toxicity is a significant concern with CAR T - cell therapies, since they have the capacity to elicit not only expected serious adverse events but also unexpected ones, including cytokine release syndrome (CRS), neurologic toxicity, «on target / off tumor» recognition, and anaphylaxis.

OX40 is not constitutively expressed on naïve CD4 or CD8 T cells but is induced after antigen recognition.

Central to the concept of immunoediting is the idea that T - cell recognition of tumor - specific antigens drives the destruction of early tumors, and later the antigenic «sculpting» of persistent tumor cells.

CAR therapy works by genetically modifying a person's own T - cells to express a synthetic receptor that allows cancer cell recognition.

Matsuzaki J, Tsuji T, Luescher I, Old L, Shrikant P, Gnjatic S, Odunsi K. (2014) Non-classical antigen processing pathways are required for MHC class II - restricted direct tumor recognition by NY - ESO -1-specific CD4 + T cells.

Matsuzaki J, Qian F, Luescher I, Lele S, Ritter G, Shrikant PA, Gnjatic S, Old LJ, Odunsi K. (2008) Recognition of naturally processed and ovarian cancer reactive CD8 + T cell epitopes within a promiscuous HLA class II T - helper region of NY - ESO - 1.

Tsuji T, Matsuzaki J, Caballero OL, Jungbluth AA, Ritter G, Odunsi K, Old LJ, Gnjatic S. (2012) Heat shock protein 90 - mediated peptide - selective presentation of cytosolic tumor antigen for direct recognition of tumors by CD4 + T cells.

The method could actually protect mice from a lethal vaginal dose of HSV - 2 without causing immune recognition of the siRNA.5 However, neither of these methods was effective at transducing the T cells that HIV infects; we are still testing ways to modify siRNAs that could prevent HIV transmission, with some promising leads.