Sentences with phrase «t cell reprogramming»

When researchers added a second step of T cell reprogramming for patients with residual disease, clinical benefit was seen in about 75 % of patients, said Dr. Kandalaft.

Not exact matches

The company is developing a T - cell reprogramming technology designed to generate an anti-tumor response from the patient's own immune system.

Bellicum is among the flurry of biotechs investing heavily into cell therapies such as experimental chimeric antigen receptor T - cell (CAR - T) treatments for cancer (this is the next - gen treatment that involves reprogramming immune cells to become cancer killers and has shown promise in blood cancers, which Bellicum specializes in).

This is how treatments based on a type of white blood cell called T - cells are curing some cancers, rather than just slowing their advance (see «Cancer meets its nemesis in reprogrammed blood cells «-RRB-.

Scientists at the Gladstone Institutes revealed, for the first time, a method to reprogram specific T cells.

CTL119 manufacturing begins with a patient's own T cells, some of which are removed and then reprogrammed in Penn's Clinical Cell and Vaccine Production Facility with a gene transfer technique designed to teach the T cells to target and kill tumor cells.

In PLAT - 02, the CAR T cells are reprogrammed to recognize and target the CD19 protein that is expressed by most precursor B acute lymphoblastic leukemia cells.

Summers and the research team, led by Dr. Mike Jensen at the Ben Towne Center for Childhood Cancer Research at Seattle Children's Research Institute, are opening PLAT - 04 after discovering that of the patients who relapsed in the PLAT - 02 trial, approximately 40 percent of them relapsed with a leukemia that evolved to circumvent the CAR T cells that were reprogrammed to detect and destroy cancer.

They will examine the safety and feasibility of administering cancer - fighting chimeric antigen receptor (CAR) T cells that have been reprogrammed to target the CD22 protein expressed by some leukemia cells.

Researchers are also working to develop a trial where they will reprogram CAR T cells to identify the CD19 and CD22 proteins simultaneously, enabling them to target the cancer cells from more than one angle with the initial round of T - cell immunotherapy.

With the PLAT - 04 trial, researchers will now be able to reprogram CAR T cells to detect and destroy leukemia cells that express the CD22 protein.

'' (T) he immune response involves reprogramming the entire cell and also often the entire plant,» Cann said.»

The elongated fibroblasts reprogrammed to become more T - cell - like in shape and hundreds of T - cell genes were also expressed in these skin cells.

«We were surprised that the exhausted T cell epigenetic profile was not reprogrammed,» Wherry said.

The ultimate goal is to precisely understand the mechanisms of checkpoint blockade effectiveness and bring next generation, sustainable immunotherapies to even more patients, perhaps using by using epigenetic drugs in combination with checkpoint blockade to allow epigenetic reprogramming of exhausted T cells into durable and functional memory T cells.

This lack of durability clinically is not well characterized, but these results suggest it is likely, at least partially, due to the lack of sustained or permanent reprogramming of exhausted T cells.

Using cells from mice and human livers, Toronto General Hospital Research Institute researchers demonstrated for the first time how under specific conditions, such as obesity, liver CD8 + T cells, white blood cells which play an important role in the control of viral infections, become highly activated and inflammatory, reprogramming themselves into disease - driving cells.

Typically, scientists look for a protein called Foxp3 to identify regulatory T cells, but this marker is lost when the cells are reprogrammed into another cell type.

Title: Cell plasticity in Caenorhabditis elegans: from induced to natural reprogramming Authors: Hajduskova M, Daniele T, Ahier A and Jarriault S Date: 2012 Publication Details: Genesis 50 (1): 1 - 17.

Title: Stat3 activation is limiting for reprogramming to ground state pluripotency Authors: Yang J, van Oosten A, Theunissen T, Guo G, Silva J, Smith A Date: 2010 Publication Details: Cell Stem Cell, Volume 7, Issue 3, 319 - 328, 3 September 2010

He is the principal investigator of an NCI - funded, multi-million-dollar Specialized Program of Research Excellence (SPORE) in ovarian cancer, and he is the principal investigator of a multi-million-dollar grant from the New York State Stem Cell Science program (NYSTEM) to pioneer a novel strategy of reprogramming human mature T cells and hematopoietic stem cells for generating sustained attack against ovarian cancer in patients.

Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection.

While the cancer normally excludes immune T - cells, the Evans lab discovered that modified vitamin D reprograms the cancer environment in a way that may allow the Merck drug Keytruda ® to invade and destroy the tumor.

We thaw them out onsite, we administer chemotherapy to eliminate the patient's normal lymphocytes, and then we infuse the thawed out reprogrammed CAR T cells into the patient, just like a blood transfusion.

T lymphocytes, or T cells, are removed from patients» peripheral blood and reprogrammed with a gene, CAR, that when expressed actually redirects all of the T cells against a single target.

His gene therapy — delivering nanoparticles could transform patients into their own T - cell engineering labs, allowing them to be treated with reprogrammed T cells almost from the moment of diagnosis, skipping the waiting period and high cost of current approaches.