Sentences with phrase «t cell samples»

Searching for T cells that had infiltrated the tumors, they collected as many as 50 T cell samples from a single tumor; next, the team tested each batch of T cells against other tumor samples from the same patient.

Q - MeDIP analysis of DNA methylation differences between CPA (black) and control (white) groups in men and women T cells samples for four gene promoters predicted to be more methylated in the men CPA group by microarray analysis.

Not exact matches

In blood samples from these patients, the researchers found an increase in the percentage of gamma delta T cells, similar to what they observed in mice, which remained stable over years.

Researchers are developing many different versions of CAR - T cell therapies, but the basic premise is the same: Doctors remove a patient's T cells (immune system cells that attack invaders) from a blood sample and genetically modify them to produce artificial proteins on their surfaces.

When they find an intruder, the dendritic cells brandish a sample (think of a most - wanted poster) and rush to the lymphatic system, where they present it to T cells, whose role is to form a posse and fan out through the body to hunt down and kill any proteins that look like the poster.

By varying the compositions of lipids, cues, and diffusible factors in the scaffolds, we engineered a very versatile and flexible platform that can be used to amplify specific T cell populations from blood samples, and that could be deployed in existing therapies such as CAR - T cell therapies,» said Mooney, Ph.D., a Core Faculty member at the Wyss Institute and leader of its Immunomaterials Platform.

But about 20 years ago, researchers started noticing that the levels of cytokines and T - cells, which help drive immune responses and secrete cytokines, were higher instead of lower in blood samples from people diagnosed with depression.

The team used a statistical model of T cell receptor formation to analyze receptor DNA sequences in blood samples from adult pairs of identical twins.

For one, samples like these from infancy are rare, and thus the number of children whose T cells were studied is modest.

They found that human blood samples contained T cells specific for all 20 versions of the virus.

Their analysis showed that the diversity of T - cell receptors decreased among samples of T - cells taken closer to the tumor, compared with farther away.

A bigger surprise came when the scientists surveyed the blood samples for killer T cells specific to other foreign peptides.

The researchers analysed around 200 tissue samples from children who had their tonsils removed, observing the transfer of dopamine from specialised T cells to B cells through a synaptic interaction.

Because CD4 + (helper) T cell responses have been shown to be sufficient for protection from WNV challenge (independent of B cells and CD8 + T cells) and crucial for viral clearance from the CNS, the researchers focused on the WNV - specific CD4 + T cell repertoires present in the blood samples.

They observed similar results in ART - controlled, HIV - infected patients who had undergone elective abdominal surgery: their SVF samples are positive for HIV DNA, and the researchers could show the presence of infected and virus - producing cells within the patients» adipose tissue and more specifically among adipose CD4 + T cells.

To find out, they studied T cells from blood samples from 71 children with dengue fever or dengue hemorrhagic fever.

They took a sample of each patient's T cells and added the new gene to the cells, using the same procedure and new gene in each case, while keeping the T cells from each patient separate.

Student's t tests excluding the outlier indicated a p - value of < 0.04 for the remaining five pandemic H1N1 samples compared with the IgG memory and germinal center (GC) cells or the primary IgG plasmablast responses (0.2 with EM included) and a p - value of < 0.0001 against the IgM populations.

To assess low frequency disruption events, we conducted 454 deep sequencing on all 15 sites in both control CD4 + T cells and those treated with X4 - ZFNs, yielding approximately 7,500 — 26,000 reads per site in the ZFN - treated samples (Table S2).

Precious patient samples, contamination concerns, and limited product purification options have compelled manufacturers of cellular immunotherapies (iTx) such as chimeric antigen receptor T cells (CAR - T) and T - cell receptor (TCR) technologies toward the disposables industry.

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We found significant differences in overall cellular composition between pre - and post-mortem blood samples (p < 0.001), the most notable changes induced by death being an increase in resting NK cells and CD8 T - cells, and a substantial reduction in neutrophils (Fig. 7a).

The H - 2Dbgp33 — 41 MHC - peptide tetramer was used for Ag - specific CD8 T cell identification and was provided as fluorophore - conjugated tetramers by E.J.W.. All samples were acquired on a MACSQuant flow cytometer (Miltenyi Biotec) and analyzed using FlowJo software version 10.

Studies in mouse models will permit extension of the human study to parameters that can not be assessed with human samples, and enable selective analyses of antigen - specific T and B cells.

a Cellular composition analysis for 18 cell types shows an increase in NK - cells - resting and T - cells - CD8 and decrease in Neutrophils composition from pre - to post-mortem blood samples.

This workshop focuses on considerations for development of a multiplexed immunoassays; examples of multiplexed assays for research release and other toxicities associated with CAR - T cells; and a novel flexible platform for biomarker screening and assessment of toxicities in samples exposed to CAR - T cells.

The program provides accurate, rapid genotyping and chimerism analysis; automatically identifies donor and recipient peaks in post-BMT samples, calculates percent chimerism and quality metrics for single donor or double donor cases, easily appends for longitudinal monitoring post-BMT, and has multi-lineage capabilities for chimerism analysis of T - cells, B - cells, and other cell type populations.

After the 12 - week program, the researchers drew a second blood sample from each volunteer and ran the same T cell analysis.

As part of this global aim we have demonstrated that one of the most abundant stromal populations, the cancer associated fibroblasts (CAFs), can sample and present tumour antigen to T cells in an antigen specific - antigen dependent manner resulting in T cell deletion.

The researchers first took blood samples from each of the volunteers to examine how many senescent and naïve T cells each had.

Results from the previous times (Times 1 - 3) of the Swedish longitudinal OCTO immune study indicated that a combination of high CD8 and low CD4 percentages and poor T - cell proliferation in PBL was associated with a higher 2 - year mortality in a sample of very old Swedish individuals.

2012 — Identified Correlates of Risk — MHRP researchers analyzed RV144 blood samples to determine the roles of T - cell, igG antibody and IgA antibody responses in the modulation of HIV infection risk.

In contrast, T cells in patients» blood samples, which had been apparently primed to recognize alpha - synuclein from past exposure, showed a strong response to the protein fragments.

ONC201 demonstrated (GI50 1 - 8 µM) dose - and time - dependent efficacy in acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myelogenous leukemia (CML), chronic lymphocytic leukemia (CLL), diffuse large B - cell lymphoma (DLBCL), mantle cell lymphoma (MCL), Burkitt's lymphoma, anaplastic large cell lymphoma (ALCL), cutaneous T - cell lymphoma (CTCL), Hodgkin's lymphoma (nodular sclerosis) and multiple myeloma (MM) cell lines including cells resistant to standard of care (dexamethasone in MM) and primary samples.

The study used tissue samples from 137 St. Jude patients with B - cell leukemia and 30 children with T - cell leukemia.

Finally, Hannibal's tumor sample made it to Breen's lab at NC State, where a genomic test and pathology report confirmed a diagnosis of T cell lymphoma.

Moreover, using a Bayesian deconvolution method to estimate methylation levels from the data [53], we found promoter methylation levels to be significantly inversely correlated (p value = 2.3e - 25) with previously published gene expression levels of T cells from human samples (Figure S1).