Sentences with phrase «t cell subsets»

High - resolution maps of enhancer - promoter interactions in rare primary human T cell subsets and coronary artery smooth muscle cells link variants associated with autoimmune and cardiovascular diseases to target genes.

An in - depth discussion of these techniques will be illustrated in a multi-parameter flow experiment examining human Memory T cell subsets.

Genetic Analysis of HIV Genomic DNA Sequences from Phenotypic and Antigen - specific CD4 + T Cell Subsets

We investigate which CD4 T cell subsets serve as predominant niches for viral long - term persistence, and aim at identifying specific molecular pathways in these cells that can be targeted to reduce viral persistence.

This included generated panels of monoclonal antibodies to key surface molecules, some of which enabled CD4 + T cell subsets to be separated out into those that mediated pathology and identify those CD4 + T cells, regulatory T cells, that controlled them.

During her doctoral studies, Sasha investigated primary human immunodeficiencies, lymphocyte cell death and metabolic pathways as well as memory T cell subsets in the laboratory of Dr. Andrew Snow.

Prof. Caccamo's research is focused on the role of human T cell subsets in physiology and in pathology, on the role of human T lymphocytes during M. tuberculosis infection and on the identification, optimization and evaluation of correlates of protection and tuberculosis disease.

Effects of Toll - like receptor 4 on β2 - glycoprotein I - induced splenic T cell subsets differentiation

The generation of these T cell subsets depends on the action of cytokines such as IL - 6, IL - 12 and IL - 23, produced mostly by cells of the innate immune system.

One of these T cell subsets is comprised of the CD1d - reactive invariant natural killer T cells, and over the years we have studied the development, homeostasis, activation and regulation of function of these cells, as well as their specificity and the pathways leading to the processing and presentation of antigens by CD1d.

However, little is known in humans about the biology of CD4 - CTL generation, their functional properties, and heterogeneity, especially in relation to other well - described CD4 + memory T cell subsets.

In humans, MAIT cells represent the most abundant T cell subset reacting against bacteria.

Another unconventional T cell subset with some features of innate immune cells is the intestinal intraepithelial lymphocytes (IEL) that express CD8αα homodimers, but neither CD4 nor CD8αβ.

Thus, in humans, MAIT cells are the most abundant T cell subset able to detect and kill bacteria infected cells.

We recently reported that CD8 (+) T cells responding to innate - like IL - 12 + IL - 18 stimulation and co-expressing the transcription factor Eomesodermin (Eomes) and KIR / NKG2A membrane receptors with a memory / EMRA phenotype may represent a new, functionally distinct innate T cell subset in humans.

Finally, the size of the Ly49 + CD8 + T cell subset is selectively reduced in the absence of STAT1.

Not exact matches

A subset of immune cells that manage immune system suppression, known as regulatory T cells, begins learning to tolerate the fetal cells as non-foreign.

That shift can lead to «an environment that is conducive to T - cell replication that results in amplification of subsets of viral populations and creation of genetically distinct, compartmentalized viral populations,» they explained.

«Unlike previous studies we isolated different immune cell types from the actual site of disease to determine whether specific subsets of immune cells (specific T cell groups) have equal sensitivity to vitamin D.»

The group of T - cells that have CD4 contains many subsets that have specialized functions.

The first key experiment involved removing a specific subset of activated T - cells from mouse models.

In the failing heart, they found increased CD8 + and CD4 + T - cells, and increased Th1, Th2, Th17 and Treg CD4 + subsets.

In particular, they found significant expansion of CD3 + CD8 + cytotoxic T - cells and CD3 + CD4 + helper T - cells in circulating blood, as well as increased CD4 + subsets of Th1, Th2, Th17 and Treg cells, indicating a pro-inflammatory response.

Treating the mice with antibodies against CD4 + T - cells four weeks after experimental heart attacks — to deplete that subset of T - cells — prevented the progressive abnormal enlargement of the left ventricle that leads to heart failure, as compared with untreated mice.

So the UAB researchers began to look for changes in subsets of T - cells over an eight - week period after heart attack.

Researchers found that some subsets of T cells are reduced from the bloodstream during sleep when risk of infection is low.

An additional mechanism to prevent the immune response from going «overboard,» the researchers conclude, is provided by a subset of T - cells called induced regulatory T - cells (iTreg cells).

Using this test, the team found that genetically - intact HIV hides in specific subsets of CD4 + T - cells.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

Simultaneous T cell antigen receptor (TCR) analysis in single cells and bulk subsets revealed that CD4 - TEMRA cells show marked clonal expansion compared with TCM and TEM cells and that most of CD4 - TEMRA were dengue virus (DENV)-- specific in donors with previous DENV infection.

The treatment with the engineered immune cells, called CAR - T cell therapy, may work even better if doctors transplant a subset of immune cells known as memory T cells, researchers reported February 14...

A key mechanism used by our body to induce immune tolerance is by induction of regulatory T (Treg) cells, a subset of white blood cell that orders other T cells to stand down.

The IL - 2 receptor α subunit, CD25 is commonly expressed in T - regulatory (Treg) cells and a small subset of Reed - Sternberg cells in Hodgkin's Lymphoma (HL).

«The collapse of the CD4 + T - cell system is the cardinal feature of AIDS,» Goldsmith observes, «so understanding which subsets of T cells can be infected is important in providing a clear picture of how HIV reduces the number of T cells.»

«We preferentially delete «naive T cells», since they are the main subset of white blood cells that reject grafts,» Strober says.

A T - cell marker panel that can identify subsets of tumor - associated T - cells allows scientists to identify and target subpopulations of T - cells playing unique roles in the immune response against a tumor.

«We already know white blood cells — or specifically, a subset known as T lymphocytes — provide us with a natural defence against viruses,» said Dr Ann Ager, who led the research.

Scientists from Emory Vaccine Center have now shown what molecular features distinguish the subset of T cells that wake up when re-energized by PD -1-blocking agents.

We will develop mathematical models to predict the pathways of differentiation from naive to memory and effector T - cell subsets based on the characterisation of surface marker expression, transcription factors and cytokines production at early and late time points after immunisation.

Regulatory T cells (Tregs) are a unique subset of CD4 + T cells with immunosuppressive properties.

The laboratory focuses on a subset of T cells, that recognize glycolipids, or combinations of sugar and fat.

Enhanced expression of one of these molecules, CD1d, is coupled to selective induction of invariant natural - killer T cells (iNKT), a subset of T lymphocytes that are present at low levels in lymphocyte populations and whose absence enhances autoimmunity in animal models.

Systemic vs. mucosal immunisation regimens will be compared for optimal induction of innate and adaptive immune cell subsets, including Th1, Th2, Th17, Th22 and regulatory T cells, as well as inflammation genes.

Smaller subsets of T cells are reactive toward various nonpeptidic ligands associated with nonpolymorphic MHC class - Ib (MHC - Ib) molecules.

CRI Investigator Gabriel Rabinovich and his team identify a novel mechanism of T cell homeostasis based on differential glycosylation of T helper cell subsets.

Together with the more studied regulatory T cells (Tr1 and CD25 + FOXP3 + Treg), growing evidence indicates that different subsets of dendritic cells (DC), play a critical role in promoting immune tolerance.

This subset of CD8 (+) T cells bears a memory phenotype without having encountered a foreign antigen and can respond to innate - like IL - 12 + IL - 18 stimulation.

Development and Functions of CD4 T Helper (Th) and Innate Lymphoid Cell (ILC) Subsets Jinfang ZhuNational Institutes of Health, Bethesda, USA 10 April 201804:15 pm Host: Max Löhning, DRFZ, Berlin Location: Max Planck Institute for Infection Biology, Seminar room 1/2 - Campus Charité Mitte

We have shown that invariant Natural Killer T cells (iNKT), a subset of CD1d - restricted T cells displaying innate effector functions, rewire the prostate cancer microenvironment leading to cancer control.

In this review, after a summary on the known innate CD8 (+) T - cell features in the mouse, we propose Eomes together with KIR / NKG2A and CD49d as a signature to standardize the identification of this innate CD8 (+) T - cell subset in humans.