Sentences with phrase «t cell system»

Not exact matches

The company is developing a T - cell reprogramming technology designed to generate an anti-tumor response from the patient's own immune system.

The athletic adults also appeared to have healthier and younger - looking immune systems, at least when it came to an organ called the thymus that's responsible for generating key immune cells called T cells.

The institute, which includes over 40 laboratories and more than 300 researchers, said the research would focus on modifying a patient's own immune system T - cells to target a tumor, studying ways to boost patient response to current immunotherapy drugs.

Hoping to learn something about how the human body defends itself against cancer, he had zeroed in on a complex regiment of lymphocytes called T cells, common to the immune systems in both mouse and man.

Rather than an activator of T cells, the molecule acted like a brake, stopping the immune system from its attack.

These vitamins are responsible for a number of bodily functions that ward off winter illness, including the regulation of T cells (or immune system warriors) and counteracting stress hormones that lower immunity.

The blood transports nutrients and the T cells of immune system to the painful area.

In case of inflammation, the T cells of the immune system reach the inflamed area and heal it quicker.

The T cells of the immune system travel with the blood.

The same goes for nutrients and the T cells of the immune system.

The quicker blood flow to the area means the T cells of the immune system can travel quicker to the muscle, hence the area recovers quicker from inflammation.

During inflammation the T cells of the immune system can reach the inflamed areas quicker.

«Immune system cell clones created before birth may last for decades: Identical twins may exchange T cells through cord blood before birth.»

Health service chief calls for affordable access to CAR - T, which modifies immune system to destroy cancer cells

A decade ago a drug based on an internal protein of the flu virus, called NP (for nucleoprotein), set the immune system's killer T cells into action, but it only partially protected mice from the flu.

«Our lab specializes in developing novel genetic methodologies to study T cell repertoires, but we had never applied this technology to study how the immune system responds to an infection,» says Emanual Maverakis, M.D., associate professor of dermatology at the University of California, Davis School of Medicine.

The treatment, called CAR - T immunotherapy, uses genetically engineered T cells, immune system fighters usually tasked with identifying invaders in the body,...

And a new analysis of the STEP trial, published last November in Proceedings of the National Academy of Sciences USA, provides a warning that the very vectors (adenoviruses, which are also employed in other vaccine development work) used to distribute the inactive HIV strains can actually make the immune system more vulnerable to infection by recruiting susceptible T cells to mucous membranes, where they are more likely to be infected during sexual activity.

Previously, Derek Danahy of the University of Iowa and colleagues showed that sepsis disrupts the immune system by reducing the amount and function of memory T cells that circulate throughout the body, recognizing and attacking specific bacteria, viruses, or cancer cells.

Tweaking the immune system to create CAR T cells has caused adverse reactions in some people.

To fend off HIV, researchers introduced one vaccine (ALVAC) to induce a T cell response — thereby alerting the immune system — and another (AIDSVAX) later to spur an antibody response.

We now know the virus attacks a person's T lymphocytes, a type of white blood cell that plays a central role in the immune system.

«These T - cells dampen incorrect responses of the immune system and have a strong anti-inflammatory effect.

A pre-clinical study of two drugs designed to boost T cell performance, has revealed the agents, when give in combination, may enhance the immune system's ability to kill melanoma tumors deficient in the tumor suppressor gene PTEN.

When the dendritic cells are activated, they train T cells — their allies in the adaptive arm of the immune system — to attack cancer cells anywhere in the body, whether at the site of the original tumor or distant metastases.

Thomas speculated that as many as 10 percent of T cell receptors are outliers that help the immune system recognize and rapidly respond to mutations that might otherwise help virus - infected cells and other threats delay detection.

A subset of immune cells that manage immune system suppression, known as regulatory T cells, begins learning to tolerate the fetal cells as non-foreign.

The immune system depends on molecules called T cell receptors on the surface of T cells to recognize and respond to foreign antigens from virus - infected cells, tumors and other threats.

Marta Monteiro and colleagues at the University of Lisbon, Portugal, studied mice protected from the animal equivalent of multiple sclerosis by natural killer T - cells (NKT), a class of white blood cell which helps to control the immune system.

When the T cells of your immune system are forced to deal over time with cancer or a chronic infection such as HIV or hepatitis C, they can develop «T cell exhaustion,» becoming less effective and losing their ability to attack and destroy the invaders of the body.

Chronic HIV infection results in exhaustion of the immune system, a phenomenon characterized by dysfunctional HIV - specific killer T cells.

Pembrolizumab, which is marketed under the brand name Keytruda, works by turning off the immune system's brakes, allowing its T cells to recognize and attack cancer cells.

The current test is only able to analyze part of the human immune system, namely the B - cells but not the T - cells, which are needed as helper cells to fight the infection and whose activity indicates the presence of an infection.

«With this algorithm we have a system to identify critical features of T cell receptors that recognize the same antigen and how they interact.

In effect, PD - 1 may actually help to preserve a «reserve force» of T cells that can fight on later in the long - term cellular war between the immune system and foreign invaders or tumors.

The protein puts the immune system's brakes on, keeping its T cells from recognizing and attacking cancer cells, said Dr. Antoni Ribas, the study's principal investigator and a professor of medicine in the division of hematology - oncology at the David Geffen School of Medicine at UCLA.

In a study published in March in Nature Immunology, Dr. Melnick and his team reported that it is possible to shut down Bcl6 in DLBCL without affecting its vital role in the T cells and macrophages needed to support a healthy immune system.

In reaction to infection or inflammation, immune system cells known as effector T cells (Teffs) undergo rapid changes - arming themselves and diversifying into groups that target specific diseased cells.

Researchers at Nagoya University have been studying the therapeutic effect of T cells, vital disease - fighting components in our body's immune system, for fighting cancer.

A second type of immune system cell, called regulatory T cells (Tregs), are a model of constancy, remaining stable even as Teffs go into battle mode.

The so - called STEP trial, sponsored by pharmaceutical giant Merck & Co. and the federally funded HIV Vaccine Trials Network (HVTN), was the first to test the idea of stimulating the immune system's killer T cells to hunt for the virus more aggressively, in this case using a weakened form of the cold virus to carry three genes from HIV.

Next, the team tested the GD2 CAR - T cells in mice whose brainstem was implanted with human DIPG tumors, an experimental system that Monje's lab pioneered.

We need T helper cells; they kick - start the immune system to respond to potential invaders.

But if you put that same virus into a rhesus macaque, the monkey's immune system reacts similarly to that of humans; there is severe depletion of CD4 T cells and progression to AIDS, explains U.C.S.F. researcher Peter Hunt.

One advantage of this method is that it only activates a certain type of immune cell, the dendritic cell or T - cell, and only in one part of the body, near the draining lymph nodes or tumor, which helps cut down on the system - wide side effects often seen with chemotherapy.

Antibodies and T cells against the protein could cause the immune system to attack cells carrying it, making gene therapy ineffective.

Although Coley couldn't explain precisely why or how his toxins worked, modern immunotherapy treatments help T - cells in the immune system to recognize specific cancer cells and attack them.

The researchers found that HIV spiked into semen was more successful than the virus alone at infecting T cells and macrophages (immune system cells that are believed to be the infection's initial targets in the body).

Researchers are developing many different versions of CAR - T cell therapies, but the basic premise is the same: Doctors remove a patient's T cells (immune system cells that attack invaders) from a blood sample and genetically modify them to produce artificial proteins on their surfaces.

Hiding out in CD4 cells HIV's resting place is the immune system's memory CD4 T cells, which have the ability to recognize foreign bacteria and viruses from previous encounters.