Sentences with phrase «t cell technology»

Also on the horizon for the Penn scientists are applications of CAAR T cell technology for other types of autoimmunity.

Payne researches autoimmunity, and a few years ago, a postdoctoral researcher in her laboratory, Christoph T. Ellebrecht, MD, took an interest in CAR T cell technology as a potential weapon against B cell - related autoimmune diseases.

The immune rejection that complicates organ transplants, and normally requires long - term immunosuppressive drug therapy, may also be treatable with CAAR T cell technology.

Soon Payne's lab teamed up with Milone's, which studies CAR T cell technology, in the hope of finding a powerful new way to treat these ailments.

Not exact matches

The company is developing a T - cell reprogramming technology designed to generate an anti-tumor response from the patient's own immune system.

What makes the treatment so fascinating is its underlying technology, called chimeric antigen receptor T - cell (CAR - T).

Those two companies, along with their larger competitor Novartis (nvs), are developing experimental chimeric antigen receptor T - cell (CAR - T) technology platforms, which are highly personalized treatments that involve extracting patients» immune cells, re-engineering them to target their specific cancers, and then pumping these sniper - cells back into the body.

In December, SQZ partnered with global pharma firm and cancer treatment leader F. Hoffmann - La Roche in a deal that could be worth $ 500 million or more — a large undisclosed upfront payment, and additional sums when SQZ meets certain milestones — to speed up the development of its technology specifically to inject a person's immune cells with a protein to activate a «killer T» cell response to fight off cancer.

T - Mobile, Verizon, and other carriers have been adding new technology and more cell phone sites to improve efficiency and capacity in their networks.

JCAR015 is a CD19 - directed chimeric antigen receptor technology (CAR - T) product candidate that has been under study in ROCKET in adult patients with relapsed or refractory B - cell acute lymphoblastic leukemia.

While that might not sound like a big deal, investors probably liked what Ji would be discussing: Sorrento's chimeric antigen receptor T cell (CAR - T) technology.

«The event, the fourth of its kind, seeks to raise global awareness and create a forum for collaboration around the wide array of powerful and promising cell therapies, gene therapies, and immunotherapies emerging from medical institutions around the world, as well as the impact new technology will have on humanity and society,» a press release by the Cure Foundation explains (h / t Christian Post).

All these programs partly rely on our t aste cell technology, which is continuously [being] improved and expanded.»

The next steps for this technology include incorporation of CRISPR / Cas9 gene editing to enhance T cells.

June is currently working with a consortium of academic and industry researchers, as well as scientists from the National Institute of Standards and Technology to establish sound manufacturing principles for CAR T cells.

The research involved using novel technologies to examine the T cells in human tissues.

«Our lab specializes in developing novel genetic methodologies to study T cell repertoires, but we had never applied this technology to study how the immune system responds to an infection,» says Emanual Maverakis, M.D., associate professor of dermatology at the University of California, Davis School of Medicine.

Lu's team will extract immune cells called T cells from the blood of the enrolled patients, and then use CRISPR — Cas9 technology — which pairs a molecular guide able to identify specific genetic sequences on a chromosome with an enzyme that can snip the chromosome at that spot — to knock out a gene in the cells.

Immune cells called CAR - T cells have already been engineered using other gene - editing technologies.

With chronically infected mice as their model, the researchers used a new technology called ATAC - seq to map the regulatory regions of the genome — the sections of DNA involved in switching genes on and off — in the animals» exhausted and functional CD8 + T cells.

To better understand what happens during immune reactions in the body, researchers at Tübingen University have developed a new way of labeling T - cells, allowing them to track the T - cell movement in mice using non-invasive positron emission technology (PET).

The T - cells» functions are barely hindered despite the marker — and PET technology provides high - contrast images.

T cells, which circulate in the blood, are an obvious candidate for medical applications of the technology, as these cells not only stand at the center of many disease processes, but could be easily gathered from patients, edited with CRISPR / Cas9, then returned to the body to exert therapeutic effects.

Membranes were probed with the following primary antibodies diluted in TBS - T with 5 % NFM overnight at 4 °C: calsequestrin rabbit polyclonal antibody (1:2,000 dilution, ab3516, Abcam), PPARδ rabbit polyclonal antibody (2 μg • ml — 1 dilution, ab23673, Abcam), COX polypeptide Va mouse monoclonal antibody (1:1,000 dilution, MS409, MitoSciences), phosphorylated Smad2 (1:1,000 dilution, 3101, Cell Signaling Technology), Smad2 / 3 (1:1,000 dilution, 3102, Cell Signaling Technology), GAPDH rabbit polyclonal antibody (1:1,000 dilution, ab9485, Abcam).

Precious patient samples, contamination concerns, and limited product purification options have compelled manufacturers of cellular immunotherapies (iTx) such as chimeric antigen receptor T cells (CAR - T) and T - cell receptor (TCR) technologies toward the disposables industry.

Cancer Vaccine Collaborative researchers Danila Valmori, Maha Ayyoub, Immanuel Luescher, and colleagues develop the first tetramer technology to monitor CD4 T cell responses to cancer vaccination.

Our science and technologies have demonstrated the possibility of highly potent antibody and T cell responses while maintaining safety, even with repeated administrations.

Drug delivery guru Daniel Anderson of Massachusetts Institute of Technology points out that one of the most advanced programs is Sangamo Biosciences» ongoing clinical trial to remove T cells from patients, edit their DNA to make them resistant to HIV, and reinject the modified cells.

To get there, researchers will need to resolve certain obstacles associated with CAR - T, including further customization of the technology to recognize specific / other tumor types, and predicting and limiting cross-reactivity, where CAR - T immune cells start attacking healthy cells as well.

When combined with CRISPR / Cas9 technology, researchers may be able to create even more potent, customizable T cells to keep cancers and other genetic diseases at bay.

The technology is called Chimeric Antigen Receptor T - cell therapy (CAR - T), which uses a patient's own immune cells to fight cancer.

The company is trying to combine and commercialize two very hot technologies — adoptive T - cell therapy and silencing of immune checkpoints by RNAi.

Although we believe our approaches have broad potential across multiple therapeutic areas, we are focused in oncology and have engineered our technologies to activate the immune system's natural ability to create tumor - specific cytotoxic T cells, or CTLs, to fight cancer.

He performed his post-doctoral work at the Massachusetts Institute of Technology, focusing on the gamma / delta T - cell receptor rearrangements and at Tufts University Medical School, investigating pathogenic Vbeta T - cell receptor usage in a mouse model of SLE.

Important reports from the Weiner lab include the first DNA vaccine studied for HIV as well as for cancer immune therapy of cutaneous T cell lymphoma, the early development of DNA encoded genetic adjuvants, including IL - 12, advances in gene optimization, and advances in electroporation technologies resulting in improved gene delivery.

For large - scale manufacturing, the conventional laboratory processes of adherent - cell systems (e.g., T - flasks, roller bottles, hollow - fiber technologies, and multilayer flasks) pose considerable challenges in scaling up (4).

He decided to branch into other fields in his quest to better engineer cancer - destroying T cells and joined the lab of nanoparticle expert Dr. Darrell Irvine at the Massachusetts Institute of Technology.

Like the BlackBerry Pearl 8120, the Curve 8320 supports T - Mobile's innovative HotSpot@Home technology, which enables users to make calls in locations where cell signals are weak.

T - Mobile Chief Technology Officer Neville Ray detailed the company's network strategy, which includes installing new equipment at 37,000 cell sites and refarming spectrum to launch LTE in 2013.1 The key catalyst of refarming is the additional spectrum T - Mobile will receive as a result of the termination of the AT&T transaction.

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