Sentences with phrase «t cells controls»

Furthermore, the laboratory is actively investigating how the interaction of IL - 10 with the IL -10-receptor expressed on regulatory T cells controls Foxp3 expression and Treg function.

Not exact matches

They discovered a population of NKT cells that have a gene that controls so - called regulatory T - cells, whose role is to suppress the immune response.

The mice treated with rapamycin also ended up with better quality memory T - cells than the control mice.

These are receptors on immune cells, which control for example effector T - cells by dampening their activation if damage to healthy cells is imminent.

Marta Monteiro and colleagues at the University of Lisbon, Portugal, studied mice protected from the animal equivalent of multiple sclerosis by natural killer T - cells (NKT), a class of white blood cell which helps to control the immune system.

She also sought out genes that controlled the switch for maturation of T helper cells, maintaining just the right balance of T helpers — between Th1 cells that suppress allergic responses and Th2 cells that trigger them.

They are what they sound like: regulators that keep another group of cells, T helper cells, from proliferating out of control.

Seven to eight weeks after the tumor was established, each mouse received one intravenous injection of GD2 CAR - T cells or, as a control treatment, an injection of CAR - T cells that react to a different target.

Migueles has found that for those who control the virus their CD8 T cells of are both quantitatively and qualitatively different from those who follow the typical course of disease progression.

In the mice that received GD2 CAR - T cells, the DIPG tumors were undetectable after 14 days, while mice receiving the control treatment had no tumor regression.

Using immunostaining, the researchers counted the remaining tumor cells; the mice treated with GD2 CAR - T cells had a few dozen remaining cancer cells per animal, while each control mouse had tens of thousands of cancer cells.

They demonstrated that non-obese diabetic (NOD) mice treated with a specific (AID / RAD51) pathway inhibitor had larger populations of certain B cells that were capable of suppressing diabetogenic T cell responses, and greatly reduced T1D development, compared with untreated controls.

Preclinical findings revealed that Myb gives immune cells called regulatory T (Treg) cells the «authority» to control the strength of the immune response depending on the level of «threat», from minor infections to aggressive diseases.

The researchers studied two types of cells called effector T cells, which activate the immune system to defend our body against different pathogens, and regulatory T cells, which help control the immune system and prevent it from attacking healthy parts of its environment.

The ability of tumor - infiltrating lymphocytes (TILs) such as T cells to produce multitudes of clones that overwhelm and effectively control cancer cells has been demonstrated, but the significance of the composition of T - cell repertories is unknown.

Many cancers take control of regulatory T cells to suppress the immune system, creating an environment where tumors can grow without being detected.

They discovered that genetic variation influencing a person's risk for multiple sclerosis, rheumatoid arthritis, and type 1diabetes is more likely to control gene activity in T cells than in monocytes.

Under normal conditions, T - cells and other immune cells collaborate to mount an immune response to invading mycobacteria, ultimately controlling their growth.

In Britain, in 1991, researchers led by Jim Stott at the National Institute of Biological Standards and Control in north London, stunned their colleagues by announcing that they had apparently protected monkeys from infection with the monkey virus SIV — the simian equivalent of HIV — with a vaccine based simply on human T cells.

Ipilimumab interferes with a process by which the immune system controls the activation of T cells that destroy diseased tissues.

Having more CXCR5 - positive antiviral T cells was strongly associated with better viral control, the researchers found.

In experiments in mice, UC San Francisco researchers have discovered that regulatory T cells (Tregs; pronounced «tee - regs»), a type of immune cell generally associated with controlling inflammation, directly trigger stem cells in the skin to promote healthy hair growth.

The pair of studies bring renewed focus to the epigenetics of T cells — the multilayered system of molecular switches, accelerators, and throttles that controls the activity of genes.

controls whether T cells, which play an active role in immune responses, become aggressive or suppressive.

For most available T cell immunotherapies, T cells (which play a central role in defending the body against illness) are engineered to recognize and eliminate tumors, but their activity is not specifically controlled, leading to toxicity and unwanted side effects in patients as a result of inflammation or in some cases suboptimal response to treatment.

«ILCs and T cells appear very different, but in the end, the way they control key responses is amazingly similar,» said Han - Yu Shih, Ph.D., a post-doctoral fellow at NIAMS and first author of the paper.

This result reflected earlier findings that ILC and T cell subclasses produce similar sets of cytokines, but also revealed differences in how the two cell types control the activities of these key immune response genes.

By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light - inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.

These shared T cell antigen receptors were found only among cells from psoriatic patients, not in cells from healthy controls or people with skin conditions such as atopic dermatitis.

In this paper, we report that HIV - 1 prefers to integrate into o near genes that control such changes in CD4 + T cells so that the virus is better able to remain coupled to the CD4 + T cell status.

Working in mice, the researchers analyzed regions of the genome that control the cytokine genes produced by both ILCs and T cells.

Tumors are home to diverse immune cell types, some of which remain much less explored than T cells and could also control cancer progression» says Mikael Pittet, PhD, director of the Cancer Immunology Program in the MGH Center for Systems Biology and senior author of the Science paper.

«It's the proof of concept that through therapeutic vaccination we can really re-educate our T cells to control the virus,» says Beatriz Mothe, a clinician at IrsiCaixa AIDS Research Institute in Barcelona, Spain, who presented the results here at the Conference on Retroviruses and Opportunistic Infections.

Before the vaccination, only 4 % of the participants» cytotoxic T lymphocytes (a type of white blood cell that helps control infections) specifically targeted these conserved proteins; after vaccination, that jumped to 67 %.

In animal models, the modified T cells greatly reduced the tumor burden and prolonged overall survival: All mice that received the modified T cells were alive 44 days after treatment versus 29 percent and 17 percent of the study's two control groups.

Supported by comparative control testing, in which the researchers induced inflammation using very similar antigens not matching the specific T - cell, they were able to prove that T - cells only migrate into tissue inflamed by their specific antigen.

Because of the consistency among many cells, they concluded that TCF - 1 control of T - cell fate is fundamentally important in determining what a cell will become.

They observed similar results in ART - controlled, HIV - infected patients who had undergone elective abdominal surgery: their SVF samples are positive for HIV DNA, and the researchers could show the presence of infected and virus - producing cells within the patients» adipose tissue and more specifically among adipose CD4 + T cells.

Although the functional importance of TCF - 1 in T cells has been known for more than 25 years, the mechanism by which this protein controls T - cell identity remained unknown.

This «friendly fire» goes unchecked due to the failing of another type of immune cell: called the T - reg, which controls T - effector cells, shutting them down when they are not needed.

They hypothesized that a different type of CD8 T cells — one that acts more like a stem cell — could help control the infection long term.

T, B, and NK cell counts and function, including antigen - specific responses, were comparable to those of age - matched controls.

The current study found that mice meant to serve as a model of ischemic human heart failure (weaker blood flow after a heart attack) had higher levels of activated, pro-inflammatory macrophages, monocytes, dendritic cells and T cells trafficking between their hearts and spleens than did control mice with healthy hearts.

Blocking PD - 1 can reinvigorate exhausted T cells and improve control of chronic infections and cancer.

Compared with a control T cell (left), loss of Rab27a (right) blocks the delivery of late endosomes (red) to the plasma membrane, inhibiting the recruitment of Gag (green) to HIV - 1 assembly sites.

Using cells from mice and human livers, Toronto General Hospital Research Institute researchers demonstrated for the first time how under specific conditions, such as obesity, liver CD8 + T cells, white blood cells which play an important role in the control of viral infections, become highly activated and inflammatory, reprogramming themselves into disease - driving cells.

«This is because the stress led to poor function against the cancer by T - cells, which are very important in the immune system's control and surveillance of tumours and are a major target in many immunotherapy treatments.»

To determine whether ZFN - mediated disruption of cxcr4 indeed protects CD4 + T cells from an in vitro HIV challenge, human CD4 + T cells from three different ccr5 wild type donors were stimulated and transduced with AdX4 - ZFNs or an AdR5 - ZFNs control.

(A) Ccr5Δ32 CD4 + T cells were stimulated on day 0 and transduced on day 1 with an Ad5 / F35 vector expressing the X4 - ZFNs, R5 - ZFNs, or an untransduced control.

Briefly, human CD4 + T cells were stimulated with anti-CD3 / anti-CD28 beads and transduced with either AdX4 - ZFNs or an AdR5 - ZFNs control at an MOI of 600.