Sentences with phrase «t cells in»

We hypothesize that Treg frequency and ratio to CD8 + T cells in BCL will be correlated with clinical behavior.

In addition, combining tacrolimus with CsA in cases refractory to each administered alone may help improve overall response as tacrolimus has been shown to act synergistically with CsA in suppressing the proliferation of T cells in vitro.

As mentioned above, the effectiveness of T cells in the body's immune response is highly dependent on certain amino acids, most notably arginine.

For example, a reduction in the number of immune cells called helper T cells in people with AIDS may play a role in the development and progression of psoriasis and psoriatic arthritis in these patients.

Therefore, at the time point used by Knowlden et al, labeled T cells in LNs might have included those that have re-entered the LNs.

(A — D) Analysis of the intranodal migration of WT and Lpar2 - / - CD4 + T cells in the PLN of WT mice by intravital two - photon microscopy.

Virus variants with weaker stimulation gave rise to tissue - resident memory T cells in the mouse brain that were better able to fight off a second infection there.

We measured the abundance of T cells in circulation and intestinal tissues that respond to intestinal microbes and determined their clonal diversity.

One found that people who had more T cells in their tumors before the treatment began tended to fare better.

Then, we systematically compared the effect of the hinge domains on the growth kinetics, cytokine production, and cytotoxicity of CAR T cells in vitro and in vivo.

And while the human and T cells they studied in the laboratory were not specifically skin T cells they were isolated from mouse cell culture and from human blood — the skin has a large share of T cells in humans, he says, approximately twice the number circulating in the blood.

These observations confirmed our results of the proliferation assays which failed to show any evidence of activated T cells in tolerant animals.

A biomarker used to measure cell proliferation found a decrease in the activation of CD4 + T cells in the colon of the monkeys given both ARVs and probiotics while a cytokine test found the «overall functionality» of the CD4 + T cells in the colon of the probiotic arm had improved.

Indeed, HPCs failed to stimulate allogenic T cells in proliferation assays, in contrast to splenocytes and bone marrow cells.

In this study, we explored the antitumor potential of prostate stem cell antigen (PSCA)- redirected CAR T and mucin 1 (MUC1)- redirected CAR T cells in tumor models of NSCLC.

They applied epigenetic drugs and found that the numbers of T cells in the tumor increased.

In contrast, T cells in patients» blood samples, which had been apparently primed to recognize alpha - synuclein from past exposure, showed a strong response to the protein fragments.

We also assessed their functional phenotypes and effects on intestinal resident cell populations, and studied alterations in microbe - reactive T cells in patients with chronic intestinal inflammation.

Of further interest was the observation that T cells in the 129SvJ and the MRLs were GFPdim, consistent with possible preferential GFP methylation in lymphocyte progenitors.

Brenchley said after five months the macaques treated with ARVs and probiotics had «enhanced reconstitution» of CD4 + T cells in the colon compared to the ARV - only arm.

Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in utero.

Four infants had rash, lymphadenopathy, and oligoclonal populations of T cells in the periphery.

Knocking out or blocking the activity of Nrp1 on regulatory T cells in mouse models of several human cancers, including the deadly skin cancer melanoma, led to reduced, delayed or complete elimination of the tumors.

Heninger AK, Monti P, Wilhelm C, Schwaiger P, Kuehn D, Ziegler AG, Bonifacio E. Activation of islet autoreactive naive T cells in infants is influenced by homeostatic mechanisms and antigen presenting capacity.

A thorough longitudinal analysis of the CMV - specific T cells in nonagenarians showed a stable pattern with respect to frequency, phenotype, and clonal composition.

Matsuzaki J, Gnjatic S, Mhawech - Fauceglia P, Beck A, Miller A, Tsuji T, Eppolito C, Qian F, Lele S, Shrikant P, Old LJ, Odunsi K. (2010) NY - ESO - 1 specific tumor infiltrating CD8 + T cells in human ovarian cancer: negative regulation by LAG - 3 and PD - 1.

The CMV - specific CD4 + T cells in elderly subjects had severely restricted replicative capacity.

Profound Metabolic, Functional and Cytolytic Differences Characterize HIV - Specific CD8 T Cells in Primary and Chronic HIV Infection.

We then examined whether VPA regulated immune homeostasis and ameliorated GVHD through inducing apoptosis of CD4 + T cells in vivo.

Lindestam Arlehamn CS, Gerasimova A, Mele F, Henderson R, Swann J, Greenbaum JA, Kim Y, Sidney J, James EA, Taplitz R, McKinney DM, Kwok WW, Grey H, Sallusto F, Peters B, Sette A. Memory T cells in latent Mycobacterium tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3 + CCR6 + Th1 subset.

The really interesting thing, though, is that an entire population of young T cells can be «corrupted» by the older T cells in their midst.

Phenotypic and functional characterization of T cells in white matter lesions of multiple sclerosis patients

Invariant natural killer T cells in asthma and chronic obstructive pulmonary disease.

We used Rag1 - / - mouse splenocytes, a source of ILC3s, because the absence of T cells in this model makes ILC3s the dominant IL -22-expressing cell type [40].

They showed that T cells in mice that could not make PSGL - 1 delayed tumor growth, suggesting that blocking PSGL - 1's function would help T cells fight tumors.

As part of this global aim we have demonstrated that one of the most abundant stromal populations, the cancer associated fibroblasts (CAFs), can sample and present tumour antigen to T cells in an antigen specific - antigen dependent manner resulting in T cell deletion.

Their poster presentation entitled, «Effect of Exercise on T Cells in Cancer Survivors,» will be discussed at The Integrative Biology of Exercise VI meeting being held October 10 - 13 at the Westin Westminster Hotel in Westminster, CO..

In 2008, he obtained his Ph.D. from the University of Southampton, United Kingdom, where he studied the mechanisms of accumulation and activation of T cells in human asthma.

The reservoir of latent HIV in the gut is poorly understood, especially because resting memory T cells in the gut are different than those in lymphoid tissues and blood.

Laura Bilek, Graham Sharp, and Geoffrey Thiele, all of the University of Nebraska Medical Center, and Daniel Shackelford, Colin Quinn, and Carole Schneider, all of Rocky Mountain Cancer Rehabilitation Institute, analyzed T cells in the blood of cancer survivors before and after a 12 - week exercise program.

Absolute numbers of IFN - γ — , IL - 17A — , and IFN - γ / IL -17 A — producing CD4 + T cells in MLN (C) and spleen (D).

Dr. Sadelain's work has focused on developing novel strategies to extend survival of CAR T cells in the body and enable T cells with increased potency to overcome the resistance imposed by tumor and other cells in the tumor microenvironment.

Accumulation of metal - specific T cells in inflamed skin in a novel murine model of chromium - induced allergic contact dermatitis.

After infusion, the signal from the genetically modified T cells in the peripheral blood increased up to 100-fold and the DNRII - LSTs persisted for up to 4 years, according to the authors.

In infected mice, absolute numbers of splenic gp33 - specific CD8 T cells in immunized mice were increased 6-fold compared with control mice as shown by IFN - γ production with peptide stimulation (Fig. 2B).

The total number of TNF - α — producing gp33 - specific CD8 T cells in immunized mice was increased by ∼ 4-fold, a difference that remained with IFN - γ blockade (Fig. 4D).

Presence of CD8 + T cells in the ectocervical mucosa correlates with genital viral shedding in HIV - infected women despite a low prevalence of HIV RNA - expressing cells in the tissue.

IFN - γ production is one of the primary effector functions of activated CD8 T cells in response to LCMV infection, and has been shown to be a key component of mortality in the naive mouse model of FHL2 (8).

PD - 1 and CD103 Are Widely Coexpressed on Prognostically Favorable Intraepithelial CD8 T Cells in Human Ovarian Cancer.

Heninger AK, Monti P, Wilhelm C, Schwaiger P, Kuehn D, Ziegler AG, Bonifacio E. Activation of islet autoreactive naïve T cells in infants is influenced by homeostatic mechanisms and antigen presenting capacity.