Sentences with phrase «t cells in the lab»

Probing the T cells in the lab, they saw that cells from the children who continued down the path toward type 1 diabetes were not normal.

Not exact matches

This new kind of approach to fighting blood cancers is truly personalized; immune T - cells are extracted from patients, genetically tinkered to home in on an destroy cancerous cells, multiplied in a lab, and then jolted back into the patient's body within about two weeks.

«Our lab specializes in developing novel genetic methodologies to study T cell repertoires, but we had never applied this technology to study how the immune system responds to an infection,» says Emanual Maverakis, M.D., associate professor of dermatology at the University of California, Davis School of Medicine.

They found high levels of the regulatory T - cells in patients treated with post-transplant cyclophosphamide, and lab - cultured cells survived cyclophosphamide treatment.

The scientists also showed, in lab - cultured human cells, that an ALDH - blocking drug strips regulatory T - cells of their ability to grow and protect themselves from cyclophosphamide.

Next, the team tested the GD2 CAR - T cells in mice whose brainstem was implanted with human DIPG tumors, an experimental system that Monje's lab pioneered.

For the past several years, researchers have been modifying T cells so they can attack leukemia, but the cells must be painstakingly isolated from the patients themselves and grown in a lab.

After the modified T cells make many copies of themselves in the lab, they're unleashed in the patient's bloodstream to find and kill cancer cells.

Because regulatory T cells reduce inflammation in lab animals, cardiologist Ziad Mallat at the French National Institute of Health in Paris and his colleagues theorized that regulatory T cells are trying to protect against atherosclerosis.

The researchers found that the protein, called VRC07 - αCD3, triggered the activation and killing of latently HIV - infected helper T cells when the cells were taken from patients on antiretroviral therapy and then incubated in the lab with the patients» own killer T cells.

«We studied human T cells, isolated from blood donors of all ages, to compare mature cytotoxic T cells with naive ones,» said Philip Ansumana Hull, graduate student in Ott's lab and one of the first authors of the study.

«This one - two punch of discoveries underscores the critical value of basic science — by uncovering the major cause of CD4 T cell depletion in AIDS, Dr. Greene's lab has been able to identify a potential new therapy for blocking the disease's progression and improving on current antiretroviral medications.»

«Our lab is interested in understanding how T - cell identity is established,» Vahedi said.

Soon Payne's lab teamed up with Milone's, which studies CAR T cell technology, in the hope of finding a powerful new way to treat these ailments.

Around the same time, Irvine's lab developed a new type of T cell vaccine that hitches a ride to the lymph nodes by latching on to the protein albumin, found in the bloodstream.

By blocking a specific cell signaling pathway in lab animals, researchers reversed signs of chronic immune activation, thereby boosting T - cell recovery and viral suppression.

Often unrecognized are the countless folks who work in the spaces between the lab and the clinic — people responsible for doing everything from manufacturing CAR T cells to gaining federal approval for new trials.

Rather than round up a patient's T cells and re-engineer them in a lab to find cancer, this treatment harvests a class of immune «helpers» called dendritic cells.

The Dellabona / Casorati lab investigates T cell responses in tumor immunosurveillance and immunotherapy, by combining a variety of approaches in pre-clinical and clinical models.

Now, a new STEM CELLS study from the labs of Qing - Ling Fu (Sun Yat - sen University, Guangzhou) and Zhongquan Qi (Xiamen University, Fujian, PR China) has described the effect of iPSC - MSCs on immune T cells in a relevant in vivo mouse mCELLS study from the labs of Qing - Ling Fu (Sun Yat - sen University, Guangzhou) and Zhongquan Qi (Xiamen University, Fujian, PR China) has described the effect of iPSC - MSCs on immune T cells in a relevant in vivo mouse mcells in a relevant in vivo mouse model.

In CAR T therapy, a person's own T cells — disease - fighting immune cells — are removed and sent to a lab where they are genetically re-engineered to produce chimeric antigen receptors (CARs) on their surface.

His plans for research in his own lab involve «continuing to look at the mechanisms of T cell dysfunction in human and mice.

«We knew that TET proteins were involved in human cancer but we didn't know how they regulated T cell development,» says Angeliki Tsagaratou, Ph.D., an instructor in the Rao lab and the study's first author.

SENS Foundation is funding ongoing work in the lab of Dr. Janko Nikolich - Zugich to investigate the effects of clearance of anergic, «senescent» cytotoxic CD8 + T - cells on immunosenescence, (22) and is interested in the targeting of other such cells.

The Sette lab's research on DENV encompasses large - scale epitope identification (supported by an HHS contract) and diverse studies towards understanding the role of T cells and HLA variants in the development of (or protection from) DENV disease (supported in part by a consortium grant led by Eva Harris at UC Berkeley).

The lab is characterizing the quantity and quality (i.e. B and T cell) of the immune responses induced or generated by these DNA plasmids in order to improve their ability to mediate virus neutralization and clearance.

Although progress toward harnessing the immune system to attack tumors has been «enormous,» he said, his lab and many others are seeing in more and more studies — in lab mice as well as patients — that «immuno - oncology» will not be as simple as stimulating T cells to attack tumors.

His lab has extensive experience evaluating and modulating T cell responses to tumors and viruses, including introducing genes into T cells to impart specificity and modulate function, designing strategies to overcome tolerance and enhance in vivo activity, and developing mouse models that more accurately model human immune responses to candidate vaccines.

As part of a large NIH - funded effort to develop immunotherapies for this allergy (the Inner City Asthma Consortium, or ICAC), the Sette lab has thus identified dominant epitopes to characterize T cell responses in allergic individuals before and after immunotherapy.

Adrienne Long, an M.D. / Ph.D. student at Northwestern University presented a fascinating talk aimed at understanding why CAR - Ts specific for GD2, an antigen found on sarcoma cells, work in the lab but have no activity in the clinic.

CAR - T cell therapy is a specific form of adoptive T cell transfer in which T cells are removed from the patient, genetically engineered in the lab to recognize a cancer antigen, expanded to billions of copies, and then returned to the patient.

«We systematically screened over 50 methyltransferases to determine which ones regulate latency in infected T cells,» said Daniela Boehm, postdoctoral scholar in the Ott lab and first author of the study.

Important reports from the Weiner lab include the first DNA vaccine studied for HIV as well as for cancer immune therapy of cutaneous T cell lymphoma, the early development of DNA encoded genetic adjuvants, including IL - 12, advances in gene optimization, and advances in electroporation technologies resulting in improved gene delivery.

He decided to branch into other fields in his quest to better engineer cancer - destroying T cells and joined the lab of nanoparticle expert Dr. Darrell Irvine at the Massachusetts Institute of Technology.

While the cancer normally excludes immune T - cells, the Evans lab discovered that modified vitamin D reprograms the cancer environment in a way that may allow the Merck drug Keytruda ® to invade and destroy the tumor.

As part of my medical training in hematology and oncology, I began a postdoc at MIT in the lab of Herman Eisen in the early eighties when molecular biology was just coming into its own: The T - cell receptor had just been discovered (work to which the Eisen lab contributed), and HIV was about to be identified as the cause of AIDS.