Sentences with phrase «t cells in their immune systems»

When susceptible people come into contact with flakes of cat skin called dander, T cells in their immune systems set off a chemical chain reaction that produces the familiar symptoms of allergy, including sneezing, runny noses, itching and asthma.

Not exact matches

Hoping to learn something about how the human body defends itself against cancer, he had zeroed in on a complex regiment of lymphocytes called T cells, common to the immune systems in both mouse and man.

In case of inflammation, the T cells of the immune system reach the inflamed area and heal it quicker.

«Our lab specializes in developing novel genetic methodologies to study T cell repertoires, but we had never applied this technology to study how the immune system responds to an infection,» says Emanual Maverakis, M.D., associate professor of dermatology at the University of California, Davis School of Medicine.

The treatment, called CAR - T immunotherapy, uses genetically engineered T cells, immune system fighters usually tasked with identifying invaders in the body,...

And a new analysis of the STEP trial, published last November in Proceedings of the National Academy of Sciences USA, provides a warning that the very vectors (adenoviruses, which are also employed in other vaccine development work) used to distribute the inactive HIV strains can actually make the immune system more vulnerable to infection by recruiting susceptible T cells to mucous membranes, where they are more likely to be infected during sexual activity.

Tweaking the immune system to create CAR T cells has caused adverse reactions in some people.

We now know the virus attacks a person's T lymphocytes, a type of white blood cell that plays a central role in the immune system.

A pre-clinical study of two drugs designed to boost T cell performance, has revealed the agents, when give in combination, may enhance the immune system's ability to kill melanoma tumors deficient in the tumor suppressor gene PTEN.

When the dendritic cells are activated, they train T cells — their allies in the adaptive arm of the immune system — to attack cancer cells anywhere in the body, whether at the site of the original tumor or distant metastases.

Chronic HIV infection results in exhaustion of the immune system, a phenomenon characterized by dysfunctional HIV - specific killer T cells.

In effect, PD - 1 may actually help to preserve a «reserve force» of T cells that can fight on later in the long - term cellular war between the immune system and foreign invaders or tumorIn effect, PD - 1 may actually help to preserve a «reserve force» of T cells that can fight on later in the long - term cellular war between the immune system and foreign invaders or tumorin the long - term cellular war between the immune system and foreign invaders or tumors.

The protein puts the immune system's brakes on, keeping its T cells from recognizing and attacking cancer cells, said Dr. Antoni Ribas, the study's principal investigator and a professor of medicine in the division of hematology - oncology at the David Geffen School of Medicine at UCLA.

In a study published in March in Nature Immunology, Dr. Melnick and his team reported that it is possible to shut down Bcl6 in DLBCL without affecting its vital role in the T cells and macrophages needed to support a healthy immune systeIn a study published in March in Nature Immunology, Dr. Melnick and his team reported that it is possible to shut down Bcl6 in DLBCL without affecting its vital role in the T cells and macrophages needed to support a healthy immune systein March in Nature Immunology, Dr. Melnick and his team reported that it is possible to shut down Bcl6 in DLBCL without affecting its vital role in the T cells and macrophages needed to support a healthy immune systein Nature Immunology, Dr. Melnick and his team reported that it is possible to shut down Bcl6 in DLBCL without affecting its vital role in the T cells and macrophages needed to support a healthy immune systein DLBCL without affecting its vital role in the T cells and macrophages needed to support a healthy immune systein the T cells and macrophages needed to support a healthy immune system.

In reaction to infection or inflammation, immune system cells known as effector T cells (Teffs) undergo rapid changes - arming themselves and diversifying into groups that target specific diseased cells.

Researchers at Nagoya University have been studying the therapeutic effect of T cells, vital disease - fighting components in our body's immune system, for fighting cancer.

The so - called STEP trial, sponsored by pharmaceutical giant Merck & Co. and the federally funded HIV Vaccine Trials Network (HVTN), was the first to test the idea of stimulating the immune system's killer T cells to hunt for the virus more aggressively, in this case using a weakened form of the cold virus to carry three genes from HIV.

One advantage of this method is that it only activates a certain type of immune cell, the dendritic cell or T - cell, and only in one part of the body, near the draining lymph nodes or tumor, which helps cut down on the system - wide side effects often seen with chemotherapy.

Although Coley couldn't explain precisely why or how his toxins worked, modern immunotherapy treatments help T - cells in the immune system to recognize specific cancer cells and attack them.

The researchers found that HIV spiked into semen was more successful than the virus alone at infecting T cells and macrophages (immune system cells that are believed to be the infection's initial targets in the body).

Hiding out in CD4 cells HIV's resting place is the immune system's memory CD4 T cells, which have the ability to recognize foreign bacteria and viruses from previous encounters.

In the presence of Acinetobacter and Akkermansia, they became a particular type of T helper cell, which trigger inflammation and help the immune system kill off invaders or infected cells, the researchers report today in the Proceedings of the National Academy of Sciences (PNASIn the presence of Acinetobacter and Akkermansia, they became a particular type of T helper cell, which trigger inflammation and help the immune system kill off invaders or infected cells, the researchers report today in the Proceedings of the National Academy of Sciences (PNASin the Proceedings of the National Academy of Sciences (PNAS).

Allison's seminal work focuses on a protein called CTLA - 4, which reins in T - cell activation in the immune system.

Three of the genetic regions associated with PSC fall within a single biological system that underlies variation in T cells, cells important to our immune response.

Previous studies have found evidence that IL - 27 has a moderating effect on the Th2 response, and in general, keeps T - cells — the «battle tanks» of the immune system — from causing too much damage.

«Hodgkin lymphoma is unusual among cancers in that it consists of a small number of tumor cells in a sea of inflammatory cells and immune system cells, including T cells that don't work very effectively.»

The researchers then introduced the two strains into mice transplanted with a human immune system and watched in real time as HIV spread from one CD4 + helper T cell to another.

«In this study we found that NF - κB activity is strongly associated with immune system T - cell infiltration in lung cancer,» explained study co-author Dung - Tsa Chen, Ph.D., member of the Biostatistics Department at MoffitIn this study we found that NF - κB activity is strongly associated with immune system T - cell infiltration in lung cancer,» explained study co-author Dung - Tsa Chen, Ph.D., member of the Biostatistics Department at Moffitin lung cancer,» explained study co-author Dung - Tsa Chen, Ph.D., member of the Biostatistics Department at Moffitt.

The class of medications that he conceived, known as immune checkpoint inhibitors, works counterintuitively: By turning off one of the immune system's built - in safeguards, the inhibitors allow T cells — the system's foot soldiers — to attack tumors more effectively.

Associate Professor Palmer said that this next - generation test showed that HIV hides in the body's immune memory T - cells, which is how it avoids detection from the immune system.

In a decades - long game of hide and seek, scientists from Sydney's Westmead Institute for Medical Research have confirmed for the very first time the specific immune memory T - cells where infectious HIV «hides» in the human body to evade detection by the immune systeIn a decades - long game of hide and seek, scientists from Sydney's Westmead Institute for Medical Research have confirmed for the very first time the specific immune memory T - cells where infectious HIV «hides» in the human body to evade detection by the immune systein the human body to evade detection by the immune system.

In an effort to block Aire and prevent the immune system from killing off T - cells that might recognize melanoma, researchers tested a compound, an anti-RANKL antibody in micIn an effort to block Aire and prevent the immune system from killing off T - cells that might recognize melanoma, researchers tested a compound, an anti-RANKL antibody in micin mice.

The rapid drop in circulating T cells during sleep «show [s] that even one night without sleep affects the adaptive immune system,» says first author Luciana Besedovsky.

«We have immune cells called T - cells that are really good at killing off cancer cells, but there is an inhibition system in place to prevent autoimmunity,» said the study's senior author Maureen Su, MD, UNC Lineberger member and associate professor in the UNC School of Medicine Division of Pediatric Endocrinology.

However, it is this small proportion of virus that hides in the effector memory T - cells and stops the immune system from fully destroying the virus and eliminating it from the body.

And a new analysis of the stopped STEP trial, published online Monday in Proceedings in the National Academy of Sciences, provides a warning that the very vectors (adenoviruses, which are also employed in other vaccine development) used to distribute the inactive HIV strains can actually prime the immune system to be infected by recruiting susceptible T cells to mucous membranes, where they are more likely to be infected during sexual activity.

«Research into basic workings of immune system points to way of improving therapies for cancer: Differences in wiring of «exhausted» and effective T cells indicate possible gene - editing targets.»

The treatment, called CAR - T immunotherapy, uses genetically engineered T cells, immune system fighters usually tasked with identifying invaders in the body, such as bacteria, viruses or foreign cells.

This is an illustration showing interactions between components of the AH10 - 7 compound (yellow), an immune system antigen - presenting cell (gray), and an invariant natural killer T cell (green and blue) that spark activation of iNKT cells in «humanized» mice.

T and B cells are vital players in the immune system; their job is to circulate through the body, find infectious agents, and mount a protective response.

In this way, aggressive autoimmune T cells are eliminated from the immune system.

Researchers in the Departments of Biomedicine and Nephrology at the University Hospital and the University of Basel have discovered that the immune system uses a molecular biological clock to target intolerant T cells during their maturation process.

Patients who received the DNA for 12 weeks apparently made altered proinsulin proteins that signal the immune system to rein in the rogue T cells.

Kipnis and his team first suspected a link between the immune system and social behavior when they found that mice lacking T cells, key components of the immune system, show little interest in their peers.

Increasing expression of a chemical cytokine called LIGHT in mice with colon cancer activated the immune system's natural cancer - killing T - cells and caused primary tumors and metastatic tumors in the liver to shrink.

In the tea drinkers» immune systems, gamma delta T cells produced five times more infection - fighting interferon when exposed to disease - causing bacteria than did the T cells of the coffee drinkers.

Commonly referred to as the sentries of our immune system, T cells are the villains in diabetes.

Patients in the study were treated with immune checkpoint inhibitors that block the activation of PD1, a protein on immune system T cells that halts immune response.

Results from a clinical trial investigating a new T cell receptor (TCR) therapy that uses a person's own immune system to recognize and destroy cancer cells demonstrated a clinical response in 80 percent of multiple myeloma patients with advanced disease after undergoing autologous stem cell transplants (ASCT).

This study is the first to selectively target ILCs in the presence of an intact immune system, and these findings suggest that under normal conditions, ILCs play a critical role in dampening the anti-bacterial T - cell response using MHCII.