Sentences with phrase «tal effector»

This correspondence makes it possible to rapidly identify TAL effector targets, to engineer novel TAL effectors with custom assortments of repeats to bind DNA sequences of choice, and even to customize genes for TAL effector activation (or prevent it!).

Although the study looked at CRISPR - Cas9 gene editing, the researchers believe their findings extend to other gene - editing tools such as zinc - finger nucleases (ZFN) and TAL effector nucleases.

Designed «staple proteins» based on TAL effectors are the key to the method.

TAL effectors are produced in nature by certain bacteria that infect plants and are able to bind to specific sequences in the plant DNA, thereby neutralizing the plant's defense mechanisms.

Functional Analysis of Bacterial TAL Effectors and the Targeted Susceptibility Genes in Plants.

Prior to Cas9 activators, similar tools were made using other DNA binding proteins such as zinc fingers (ZF) and TAL effectors (TALE).

For the past 20 years, he has identified and characterized several important naturally occurring TAL effectors in the rice pathogen Xanthomonas oryzae for their disease promoting ability, and most recently he has helped harness the disease - causing TAL effectors for targeted gene editing.

Major areas of activity in our lab include 1) identification and characterization of Sgenes, 2) genomic analyses to identify the diversity of TAL effectors in pathogen populations and understand their evolution, and 3) structural and biochemical studies to better harness the unique properties of these proteins for applications such as targeted gene regulation and genome editing.

TAL effectors recognize their DNA targets in a modular way: tandem, variable structural repeats in these proteins independently specify single contiguous bases in the DNA.