Sentences with phrase «talen targets»
(B) TALEN targets for the generation of the CCHa2 - RTAL - 34 allele [1L, 1R, 2L, and 2R; underlined].
http://journals.plos.org/ Not exact matches
So they turned to a second DNA - targeting technique, known as TALENs, that entails inducing cells to produce enzymes that work together like a pair of scissors to cut DNA.
What's more, say the researchers, the cancer - causing effects of off - target deletions mistakenly created by the V (D) J enzyme need to be considered in designing site - specific enzymes for genome modification such as zinc - finger nucleases, TALENS, or CRISPRs.
Cellectis used an older method called TALEN to target TCRαβ, but the revolutionary new CRISPR method has made it much easier and cheaper to create gene - editing tools.
Another protein - based targeting strategy, TALENs, is based on the transcription activator - like effector (proteins secreted by Xanthomonas bacteria).
Science magazine heralded these transcription activator - like effector nuclease proteins, known as TALENS, as a major scientific breakthrough in 2012, nicknaming them «genomic cruise missiles» for their ability to allow researchers to target specific locations with great efficiency.
As with many TALEN - based technologies, the advent of CRISPR has made targeting much easier!
His research interest focuses on 1) development and application of TALEN and CRISPR technologies for targeted genome editing in plant species, and 2) molecular mechanism of plant / microbe interactions and crop disease resistance engineering by using the bacterial blight of rice as a model.
In a second scheme, transcription activator - like effector nucleases (TALENs) were targeted to sequences near the translation - initiation site of CCHa2 - R to create a frame - shift mutation in the CCHa2 - R coding region [24].
CCHa2 - RKO51 - 2 and CCHa2 - RTAL - 34 are putative null alleles, which were generated by gene targeting using homologous recombination and TALEN, respectively (see below).
Dr. Radislav Sedlacek and his team from the Institute of Molecular Genetics has recently published new paper on gene targeting of Rosa26 locus using TALENs.
A patent application has been filed and testing is underway on the protein — called HT - TALENs (short for HIV - targeted transcription activator - like effector nucleases)-- which uses a newly developed gene - editing technique to rid the body's cells of the immunodeficiency virus before it has a chance to multiply and possibly develop into AIDS.