Not exact matches
«Because the bacterium that causes
TB can lie dormant in someone's
lung for months or even years before it causes disease, we had no way of knowing whether a
TB case we have just diagnosed was a recent
infection — suggesting the outbreak is still going on — or whether the person was infected years ago.»
Infection normally begins in the
lungs as
TB and can spread to the brain and spinal cord, causing swelling and restricting blood flow.
TB is known for trying to block activation of T cells by infected dendritic cells, two kinds of which are primarily involved in fighting
infection: dendritic cells that migrate from the
lungs to the lymph nodes, and those that already reside in the lymph nodes.
In multiple trials of mice with both active and chronic
TB infections, researchers report that one version of the new drug — an analog known as 1599 — was as good as or better than current
TB drugs at reducing levels of the bacteria in the
lungs of mice.
HIV, which destroys the immune system, helps
TB in several ways, turning latent
TB infections active and allowing the bug to spread outside the
lungs.
And even people with «active»
TB typically confine the
infection to the
lungs and can be cured with antibiotics.
Caused by a bacterial
infection with Mycobacterium tuberculosis (MTb),
TB most commonly affects the
lungs but can affect any organ in the body.
This strain showed a highly virulent phenotype, with rapid multiplication during the early stage of
infection in a murine model of
TB with excessive
lung inflammation, and
infection with this strain resulted in more rapid death of mice than
infection with the reference H37Rv strain.