Sentences with phrase «th gene polymorphisms»

«We found associations between certain gene polymorphisms and delayed fracture healing in a sample of patients,» said J. Spence Reid, professor of orthopaedics and rehabilitation.

Illmer, T., Schuler, U. S, Thiede, C., Schwarz, U. I., Kim, R. B, Gotthard S., Freund, D., Schakel, U., Ehninger, G. and Schaich, M. MDR1 gene polymorphisms affect therapy outcome in acute myeloid leukemia patients.

Cam, F.S. et al. «Association between the ACE I / D gene polymorphism and physical performance in a homogenous non-elite cohort.»

We conducted a two - center hospital - based case - control study with a total of 374 cases and 812 controls to assess the role of five LMO1 gene polymorphisms in the neuroblastoma risk.

Furthermore, sex - specific differences in gene polymorphism are suggested by one study showing that diabetic women carrying ACE D allele have a higher risk for development of diabetic nephropathy, which was not seen in diabetic men (Table 2)(331).

The impact of common dopamine D2 receptor gene polymorphisms on D2 / 3 receptor availability: C957T as a key determinant in putamen and ventral striatum.

Additionally, low sex hormone - binding globulin (SHBG) levels may indicate diabetes - risk potentially mediated via SHBG gene polymorphisms (60, 61).

«Here we see that the same IL - 21B gene polymorphisms seem to influence the response to influenza virus vaccination, at least in a population of transplant patients who, because of their transplant status, have to receive immunosuppressing drugs.

Research Paper The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta - Analysis Le Du, Lei Lei, Xiaojuan Zhao, Hongjuan He, Erfei Chen, Jing Dong, Yuan Zeng, Jin Yang J. Cancer 2018; 9 (8): 1506 - 1517.

Furthermore, as dopaminergic mechanisms modulate pain responses, these researchers assessed the influence of the functional DRD2 gene polymorphism (957C > T) and the catechol - O - methyl - transferase (COMT) Val158Met polymorphism on the analgesic effect of rTMS.

Vitamin D receptor gene polymorphisms, serum 25 - hydroxyvitamin D levels, and melanoma: UK case - control comparisons and a meta - analysis of published VDR data.

In contrast, variants in the MTHFR gene have been associated with increased risk of neural tube defects and cardiovascular disease; however, 60 - 70 % of individuals in the general population have one of the two most common MTHFR gene polymorphisms.

«Looking for reward in all the wrong places: dopamine receptor gene polymorphisms indirectly affect aggression through sensation - seeking.»

Goyal RK, Lin Y, Schultz KR, Ferrell RE, Kim Y, Fairfull L, Livote E, Yanik G, Atlas M. Tumor necrosis factor - alpha gene polymorphisms are associated with severity of acute graft - versus - host disease following matched unrelated donor bone marrow transplantation in children: a Pediatric Blood and Marrow Transplant Consortium study.

Genome - wide association studies use «genechip» technology to identify genetic variants (single gene polymorphisms or «SNPs») that could explain differences in health between individuals.

Such environments may be more similar to the environments where much of human genetic evolution took place; indeed, they may be adaptively relevant environments [AREs; [13]-RSB- for the evolution of dopamine gene polymorphisms that have been primarily investigated in industrialized settings.

Filed Under: Events, Gene polymorphisms, Testing Tagged With: antibiotic resistance genes, anxiety, Ben Lynch, David Brady, depression, Dirty Genes, fluroquinolones, GI MAP

DRD4 and TH gene polymorphisms are associated with activity, impulsivity, and inattention in Siberian Husky dogs.

Androgen receptor gene polymorphisms are associated with aggression in Japanese Akita Inu.

The study suggests that oxytocin receptor gene polymorphisms have an impact on proximity to unfamiliar humans and on how friendly the dogs were toward the human.

Dopamine D4 receptor (DRD4) gene polymorphism is associated with attachment disorganization in infants

Association analysis of the catechol - o - methyltransferase (COMT), serotonin transporter (5 - HTT) and serotonin 2A receptor (5HT2A) gene polymorphisms with obsessive - compulsive disorder

Transmission disequilibrium tests confirm the link between DRD4 gene polymorphism and infant attachment.

Studies demonstrating this greater susceptibility of neurobiologically responsive children to both positive and negative aspects of their environments have implicated a wide variety of stressors and adversities, including paternal depression (67), marital conflict (68, 69), parental psychopathology (70), and overall family distress (71); of positive environmental features, including parental warmth (72) and supportive interventions (73); and of defining biological parameters, including physiological reactivity (e.g., 74, 75), differences in brain circuitry (76), and gene polymorphisms (77, 78).

Phenotype studies of the DRD4 gene polymorphisms in ADHD: association with oppositional defiant disorder and positive family history

Investigating the genetic basis of theory of mind (ToM): The role of catechol - O - methyltransferase (COMT) gene polymorphisms

Serotonin system gene polymorphisms are associated with impulsivity in a context dependent manner

Glucocorticoid Receptor (NR3C1) Gene Polymorphism Moderate Intervention Effects on the Developmental Trajectory of African - American Adolescent Alcohol Abuse.

Relationship of serotonin transporter gene polymorphisms and haplotypes to mRNA transcription

A meta - analysis of the association between the serotonin transporter gene polymorphism (5 - HTTLPR) and trait anxiety

For instance, developmental studies of common dopamine (DA)- regulating gene polymorphisms and their interactions with environmental factors, both positive and negative, were recently examined in meta - analysis by Bakermans - Kranenburg and van Ijzendoorn (2011).

An exploratory genetic analysis: Associations between parent depression symptoms, child temperament, and the serotonin transporter gene polymorphism (5HTTLPR).

Not exact matches

Second, new polymorphisms that arose in one group were less likely to be transmitted to other groups as gene flow was restricted.

Observed parenting behaviors interact with a polymorphism of the brain - derived neurotrophic factor gene to predict the emergence of oppositional defiant and callous — unemotional behaviors at age 3 years

Moderate level fetal alcohol exposure and serotonin transporter gene promoter polymorphism affect neonatal temperament and limbic - hypothalamic - pituitary - adrenal axis regulation in monkeys.

There have also been a number of reports of polymorphisms or mutations in genes that regulate inflammation, 48,49 energy production, 50, — , 52 and hypoglycemia53 in infants who died from SIDS, but these associations require more study to determine their importance.

Identification of novel polymorphisms in the glucokinase and glucose -6-phosphatase genes in infants who died suddenly and unexpectedly

It has been estimated that 5 % to 10 % of infants who die from SIDS have novel mutations in the cardiac sodium or potassium channel genes that result in long QT syndrome as well as in other genes that regulate channel function.44 A recent report described important new molecular and functional evidence that implicates specific SCN5A (sodium channel gene) β subunits in SIDS pathogenesis.47 The identification of polymorphisms in genes pertinent to the embryologic origin of the autonomic nervous system in SIDS cases also lends support to the hypothesis that a genetic predisposition contributes to the etiology of SIDS.

Genetic variation can take the form of common base changes (polymorphisms) that alter gene function or rare base changes (mutations) that often have highly deleterious effects.

Their preliminary analysis revealed several mutations known as single nucleotide polymorphisms (SNPs) in the ALR gene, many of which haven't been identified before.

Predisposition to vascular disease was my focus here, using genetic epidemiological studies to identify novel polymorphisms in a range of candidate genes.

After gene - typing about 3,000 people, Sturm found that how OCA2 is expressed — and how much pigment a person has — is strongly linked to three single nucleotide polymorphisms (SNPs), or single letter variations, in a DNA sequence near the OCA2 gene.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

Such gene changes, called polymorphisms, are common.

A polymorphism (rs1051730) in proximity to the cholinergic receptor, nicotinic, alpha 3 (CHRNA3) gene is associated with higher tobacco consumption among smokers and can therefore be used as a genetic proxy for high tobacco consumption.

A team at Virginia Commonwealth University in Richmond recently found that three genetic polymorphisms — variants in the «spelling» of a certain gene — are connected to nicotine addiction.

Results from a statistical analysis shows a cluster of SNPs — single nucleotide polymorphisms — in one section of a single gene, indicating the location of a mutation likely linked to autism.

The classic case of polymorphism is the gene for the different blood groups in humans.

«What we found is that if people have a specific polymorphism in the BDNF gene, they recovered to a greater extent than those with a different variant of the gene.»

Rather than measuring genetic changes directly (such as single nucleotide polymorphisms, otherwise known as SNPs), McKee and her group typically do RNA expression profiles on patients to see what genes are being expressed.