Sentences with phrase «tlr7 overactivation»

After determining the proper dosage of tamoxifen — an early trial resulted in a number of mouse deaths due to overactivation of Mecp2 — researchers settled on a four - week regimen of ramping up the gene's function.

Overactivation of AIM2 has been linked to disorders including psoriasis, an abdominal aortic aneurysm and lupus.

While IL - 18 is useful for protecting the body against external pathogens, too much of this protein leads to a harmful overactivation of the immune system, resulting in the various symptoms presented in patients.

Means notes that identifying the potential role of TREML4 in human lupus may lead to the development of drugs that could prevent or reduce the development or progression of lupus and another autoimmune disorder called Sjögren's syndrome, which also appears to involve TLR7 overactivation.

Animal studies have suggested that overactivation of TLR7 plays a role in lupus, and a gene variant that increases expression of the receptor has been associated with increased lupus risk in human patients.

Overactivation of this pathway, which most likely evolved to detect the presence of disease - bearing insects on the skin, results in increased scratching akin to that seen in patients who develop chronic itch.

These inhibitors can also bind to and inhibit the mutated factor XII, but this is not enough to completely stop the overactivation.

«We now believe that DT104's enhanced invasive ability is the result of an overactivation of invasion genes while within the challenging environment inside the protozoa,» says Carlson.

Memantine is an NMDA receptor antagonist, aimed at counteracting the overactivation of the receptor caused by the mutation.

FOP is caused by overactivation of a signaling protein involved in embryo development, BMP.

Consistently, we observed nuclear localization of β - catenin in the more - lateral mesoderm only, and β - catenin overactivation converted the mesodermal midline toward a more lateral fate and position (fig.

The endocannabinoid system regulates energy homeostasis through G protein — coupled cannabinoid - 1 receptors5, 6 located in the central nervous system and in various peripheral tissues, including adipose tissue, muscle, the gastrointestinal tract, and the liver.7 While peripheral cannabinoid - 1 receptor activation decreases adiponectin production in adipocytes, 8 central cannabinoid - 1 receptor activation in preclinical studies stimulates eating, decreases muscle, and stimulates hepatic and adipose tissue lipogenic pathways in animal models of obesity.9 In genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorders.

We hypothesized that participants with higher anxiety would have a different pattern of activation during negative emotion processing because, in behavioral studies, it was found that anxious subjects displayed hypervigilance in response to cues related to attachment threat or a prolonged overactivation of the attachment system.

More importantly, this process may interfere with the employment of the overactivation strategy in anxious individuals as we predicted.

So, like age - related overactivation generally, this age - related alteration in hemispheric specialization, a pattern dubbed «hemispheric asymmetry reduction in older adults» or HAROLD (Cabeza, 2002), means that cognitive neuroscience studies of brain aging are raising new questions with broad neuroscientific implications (Figure 1A).