Sentences with phrase «tor pathway»

Some studies suggest whey and leucine - rich foods (meat and milk) stimulate the TOR pathway, which Dr. Greger addresses in this video.

The expression of upd2 is both sugar - and lipid - sensitive and is apparently independent of the amino acid - activated TOR pathway [9].

Although no signaling molecules that act downstream of the Slif / TOR pathway have been identified yet, these fat body - derived signals ultimately regulate the production of insulin - like peptides (Drosophila insulin - like peptides; Dilps) secreted from the brain [10][9].

CCHa2 and Upd2, however, responded differently when the TOR pathway was disturbed: whereas CCHa2 expression was down - regulated in TOR - pathway - knockdown larvae, upd2 was up - regulated by the inhibition of the TOR pathway in adults [9].

The TOR pathway was inhibited by expressing TSC1 / 2 in the fat body using Lsp2 - GAL4.

Given that glucose alone is sufficient to promote CCHa2 expression, CCHa2 appears to be distinct from the currently unidentified fat body - derived factor previously proposed to act downstream of the Slif / TOR pathway [10].

These observations suggest that CCHa2 expression is responsive to glucose and the TOR pathway.

(It should be noted that the knockdown of the TOR pathway in the fat body severely affects larval growth [8]; therefore, Lsp2 - GAL4, which is expressed in the fat body at the wandering stage — after the growth period [13]-- was used to overexpress TSC1 / 2 in order to avoid secondary effects from a systemic growth defect.)

«Looking at gene expression, the ketogenic diet suppressed the longevity - related TOR pathway and insulin signaling and up - regulated the fasting - related transcription factor PPAR - alpha, a master regulator that helps the body more efficiently metabolize fat.»

«The idea would be to use mice genetically engineered to have suppressed insulin signaling, and then treat them with the drug rapamycin, which is well - known to suppress the TOR pathway.»

Not exact matches

The mutations inhibited key molecules involved in insulin signaling (IIS) and the nutrient signaling pathway Target of Rapamycin (TOR).

«We have discovered the key role played by the TOR signalling pathway in driving the expansion of the endoplasmic reticulum, and sending a cell's factories into overdrive.

A protein in the TOR signalling pathway, called SREBP, controls the flow of messages to the endoplasmic reticulum telling it to expand — and could allow cancer cells to produce enough proteins and lipids to fuel their non-stop growth.

They found that silencing the TOR signalling pathway — activated in many different types of cancer — increased ER stress in the cells.

Working in flies and mice, researchers at the Buck Institute and elsewhere discovered that TOR, a nutrient sensing pathway which is central to the aging process, drives the loss of adult stem cells.

Jasper says TOR can be regulated by a number of stimuli, and researchers are now attempting to better understand how the activity of this signaling pathway is controlled in stem cells.

Using DOS and small - molecule screening, Schreiber helped illuminate many cellular pathways, including the nutrient - response signaling network involving TOR proteins in yeast and mTOR in mammalian cells.

The fat body senses the concentration of intracellular amino acids through the activity of the Target of Rapamycin (TOR) signaling pathway, which in turn regulates the synthesis and secretion of an undescribed humoral factor (s), called the fat - body — derived signal.

In one pathway described from larvae, the fat body - specific down - regulation of either the Slimfast (Slif) amino acid transporter or the Target of Rapamycin (TOR) nutrient - sensing pathway affects systemic growth, suggesting that a hitherto unidentified amino acid - dependent signal (s) is secreted by the fat body for proper growth control [8].

That's good news, because «[p] rotein restriction is much less difficult to maintain than dietary restriction, and may be more powerful than dietary restriction,» because it suppresses both TOR and IGF - 1 — the two pathways thought responsible for the «drastic longevity and health benefits» of caloric restriction.