Sentences with phrase «tor proteins»

Hall, an ASCB member since 2002, conducts research at Biozentrum, University of Basel, Switzerland, and was recognized for his discoveries concerning the nutrient - activated TOR proteins and their central role in the metabolic... Read more

Using DOS and small - molecule screening, Schreiber helped illuminate many cellular pathways, including the nutrient - response signaling network involving TOR proteins in yeast and mTOR in mammalian cells.

Not exact matches

University of Washington researchers have found that a calorie - restricted diet reduces the activity of a cell - signaling protein called TOR - 1 that may speed up cell aging.

A protein in the TOR signalling pathway, called SREBP, controls the flow of messages to the endoplasmic reticulum telling it to expand — and could allow cancer cells to produce enough proteins and lipids to fuel their non-stop growth.

About 25 years ago, Prof. Michael Hall discovered the protein «Target of Rapamycin» (TOR) at the Biozentrum.

For a long time it has been known that the protein TOR — Target of Rapamycin — controls cell growth and is involved in the development of diseases such as cancer and diabetes.

The chemical rapamycin is used clinically as an immunosuppressant and as an anti-cancer agent that works by inactivating a protein named TOR (Target Of Rapamycin).

However, despite extensive research on TOR over the last decades, attempts to uncover the detailed structure of the protein kinase and its partners have been unsuccessful.

mTOR is a serine / threonine protein kinase that forms two distinct protein complexes within cells: one with the regulatory - associated protein of TOR (raptor) and another with the rapamycin - insensitive companion (rictor; refs.

Abbreviations: AL3E, after L3 ecdysis; FoxO, Forkhead Box O; FRE, FoxO - Response Element; GBP, Growth - Blocking Peptide; GFP, green fluorescent protein; IIS, insulin / insulin - like growth factor signaling; ILP, insulin - like peptide; L3, third larval instar; pAKT, phosphorylated AKT; ppl, pumpless; qPCR, quantitative PCR; Rheb, Ras homolog enriched in brain ortholog; TOR, Target of Rapamycin

Second, the mRNA expression of both gbp1 and gbp2 is sensitive to the protein content of the larval diet and to TOR signaling in the larval fat body.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

The team started by restricting protein in the larvae's diet, since protein restriction was already known to reduce TOR activity.

TOR plays many roles, but one of its primary tasks is to function like a wrench loosening and tightening the control of protein synthesis in response to nutrients, specifically amino acid availability.

You can find pages on this site which cover the following topics to learn more: >> > Plant to animal protein ratios (it turns out that the more plant protein we eat, the lower the disease risk), >> > IGF - 1, >> > the amino acid methionine, >> > undigested putrefaction, >> > leucine (as it relates to TOR), >> > increased insulin.

Whey protein isolate and hydrolyzed whey protein — derived from milk — are especially useful tor triggering muscle protein synthesis.

«The functional role of leucine in regulating [TOR] activity» may help explain the extraordinary results reported in the Cornell - Oxford - China Study, since «[q] uasi - vegan diets of modest protein content tend to be relatively low in leucine.»

It would be very interesting to know if luciene in protein up to the maintenance level has any effect on TOR.

The lifespan extension associated with dietary restriction may be due less to a reduction in calories, and more to a reduction in animal protein (particularly the amino acid leucine, which may accelerate aging via the enzyme TOR).