Sentences with phrase «tor signaling activity»

(C, D) Reducing TOR signaling activity in the fat body decreases gbp1 (C) and gbp2 (D) mRNA expression in the fat body.

Therefore, these results suggest that reducing TOR signaling activity in the fat body genocopies the effect of starvation.

Although there was no effect in the null mutant, we found ilp2 mRNA expression increased and AKT expression level was down regulated in larvae where either TOR signaling activity or the expression of GBP1 and GBP2 was specifically reduced in the fat body.

Not exact matches

University of Washington researchers have found that a calorie - restricted diet reduces the activity of a cell - signaling protein called TOR - 1 that may speed up cell aging.

Jasper says TOR can be regulated by a number of stimuli, and researchers are now attempting to better understand how the activity of this signaling pathway is controlled in stem cells.

The fat body senses the concentration of intracellular amino acids through the activity of the Target of Rapamycin (TOR) signaling pathway, which in turn regulates the synthesis and secretion of an undescribed humoral factor (s), called the fat - body — derived signal.

Therefore, we conclude that GBP1 and GBP2 partially rescued the effect of reduced TOR activity in the fat body and that both GBP1 and GBP2 are downstream of TOR signaling in the fat body.

Based on a number of studies, we postulate that to transmit nutritional information from the fat body to the insulin - producing cells, the fat - body — derived signal would need to have the following properties: (1) it should be produced in the fat body and secreted into the hemolymph, (2) its expression and / or secretion should be amino acid - and TOR - sensitive, (3) it should act downstream of TOR signaling to stimulate ILP secretion from the insulin - producing cells, and (4) its secretion should increase IIS activity in the entire body, resulting in increased body size.

To analyze whether overexpressing either GBP1 or GBP2 is sufficient to rescue the effect of reduced TOR activity in the fat body, we co-overexpressed suppressors of TOR signaling, TSC1 and TSC2, and either GBP1 or GBP2 in the fat body.