Sentences with phrase «tsc signaling network»

The MTA needs to invest the lion's share of its resources in upgrading a signaling network that predates World War II — and our gutless political class needs to hold the MTA to account.

London has already installed a computerized signal network on four of its 10 main subway lines, with work is underway on four more.

We're going to roll out high - speed broadband, and put in place a modern wireless and mobile signal network across Wales.»

Twenty years ago, they discovered that the gas nitric oxide (NO) is a major player in the complex signaling network that lets our neurons coordinate activity with one another.

«Our findings provide a possible flanking strategy to counteract the ability of melanoma cells to re-wire their signaling networks,» said co-coresponding author Meenhard Herlyn, Caspar Wistar Professor in Melanoma Research and director of the Melanoma Research Center at The Wistar Institute.

Professor Taylor, who co-ordinated the research, says: «Our findings provide the very first insight into how biochar stimulates plant growth — we now know that cell expansion is stimulated in roots and leaves alike and this appears to be the consequence of a complex signalling network that is focussed around two plant growth hormones.

More specifically, the team found that a diet lacking ample omega - 3 decreased the function of presynaptic cannabinoid receptors, part of the brain's signaling network that is thought to be involved in pain and appetite regulation.

Researchers are also developing rudimentary models of signaling networks in cells and simple brain circuits.

The group has already started tweaking human iPS cells using the same genes that Saitou pinpointed as being important in mouse germ - cell development, but both Saitou and Hayashi know that human signalling networks are different from those in mice.

Their work implicated the Ras pathway — a calcium - dependent signaling network that spurs neuronal growth — as playing a key role in autism.

Dyer, who recently joined the Georgia Institute of Technology and Emory University, also studies how the brain computes via its signaling networks, and this imaging technique could someday open new windows onto how they work.

Moreover, the scientists have found that these stem cells depend upon a family of proteins known as the «Wnt signaling network» — the same proteins that play a crucial role in hair and tissue regeneration — to regenerate bone in the fingertip.

In previous studies on rodents, postdoctoral scholar Clemenson and others showed that exploring the environment resulted in the growth of new neurons that became entrenched in the hippocampus» memory circuit and increased neuronal signaling networks.

A related study, also published in PLOS Genetics, shows that RPM - 1 functions as a part of a novel pathway to control β - catenin activity — this is the first evidence that RPM - 1 works in connection with extracellular signals, such as a family of protein growth factors known as Wnts, and is part of larger signaling networks that regulate development.

To this end Dr. Linding is currently leading high - level, strategic, multidisciplinary studies of signaling network dynamics driving cancer metastasis in collaboration with other labs at Harvard, Yale, The Jackson Laboratory, Memorial Sloan Kettering Cancer Center, MIT, and BRIC.

In particular, his laboratory focuses on the regulation of key signaling networks that regulate cancer cell growth and survival.

Johannessen et al. used a highly systematic approach to identify candidate genes and signaling networks that contribute to resistance.

These results suggest «all the other signaling networks [for hind limbs] are in place,» he notes.

Among the unexpected «hits» revealed by this assay were a cyclic AMP signaling network and a group of transcription factors important in melanocyte development, each suggesting potential new strategies for overcoming resistance.

His overarching aim is to advance network medicine by identifying and targeting signaling networks associated with complex diseases.

A strategic focus is to continue to develop computational tools (such as KinomeXplorer, NetworKIN, and NetPhorest) and to deploy these on genome - scale quantitative data obtained by, for example, mass spectrometry, genomic, and phenotypic screens to understand the principles of how spatio and temporal assembly of mammalian signaling networks transmit and process information at a systems level in order to alter cell behavior.

The budding yeast, Saccharomyces cerevisiae, is a prime organism for studying fundamental cellular processes, with the functions of many proteins important in the cell cycle and signaling networks found in human biology having first been discovered in yeast.

In addition, the analysis provided some hints about how chemotaxis evolved from a simple signaling network that responds slowly to environmental cues — primarily by turning on genes — to a multiprotein system that can quickly alter a cell's course.

In other disease areas, the Parkinson's disease map and the Atlas of Cancer Signalling Network, have already begun the process of integrating knowledge about the involved mechanisms in order to understand the different subtypes of these diseases.

Pypath (a Python module) lets users build custom signalling networks and combine them with other data.

Scientists have charted a significant signaling network in a tiny organism that's big in the world of biofuels research.

Before this study, just 75 of those proteins were known to be part of a redox signaling network.

It will also be used to analyse gene signalling networks in cress, fruit flies and sea urchins.

RICHLAND, Wash. — Scientists have charted a significant signaling network in a tiny organism that's big in the world of biofuels research.

Now the Strader and Jez labs at Washington University in St. Louis have made a discovery about one of the proteins in the auxin signaling network that may prove key to understanding the entire network.

They hope to enlist the new method to image electrical signaling networks in our hearts and brains.

Stuart explained that the integrated datasets from multiple analyses enabled the researchers to build a generic model of the signaling networks involved in metastatic prostate cancer.

We are also interested in other neuronal functions of the TSC signaling network, such as the control of neuron size, myelination, survival and stress responses.

This has allowed them to determine one of the most complex signaling networks that control growth and development in response to environmental change.

Zhang, Y. and Wolf - Yadlin, A. and Ross, P. L. and Pappin, D. J. and Rush, J. and Lauffenburger, D. A. and White, F. M. (2005) Time - resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.

«Our goal is to decipher the signaling networks that regulate chemotaxis and to determine how they are altered in metastatic cancer cells,» says Klemke.

What's next: In a related article not yet published, the same team of researchers shows that biological signaling networks can be understood in the context of human - engineered electrical and mechanical systems.

In August 2016, Brooke joined the faculty at SBP Medical Discovery Institute as an Assistant Professor in the Cancer Metabolism and Signaling Networks Program.

The Kops group studies the signaling networks that regulate chromosome segregation, the evolution of cell division processes and the role of chromosomal instability in cancer.

These data substantially increase existing knowledge of synapse protein phosphorylation and support a model where the synapse phosphoproteome is functionally organized into a highly interconnected signaling network.

Along with other research in this area, Schreiber's HDAC discovery and his novel «signaling network model» of chromatin revealed the genetic complex to be not just a simple structural element, but one with a key regulatory function that is central to epigenetics.

1/28/2008 Researchers Map Signaling Networks that Control Neuron Function Relationship between Thousands of Proteins at Work in the Brain Could Impact Diseases such as Alzheimer's, Parkinson's Disease, and Spinal Cord Injury In the first large - scale proteomics study of its kind, researchers at the University of California... More...

Additionally, ERK1 / 2 and AKT are known to cross talk with multiple substrates including several kinases, transcription factors, etc. which increase the complexity of the signaling network.

Using DOS and small - molecule screening, Schreiber helped illuminate many cellular pathways, including the nutrient - response signaling network involving TOR proteins in yeast and mTOR in mammalian cells.

This discovery confirms the potential of CBD against psoriasis since it adheres to the CB2 receptor to exert its biochemical action on the signalling network of our immune system.

The group went on to identify three key signalling networks that were represented by the bCSC DMR - associated genes; NFKB RB1 and TGFB1, and then analysed these networks in various breast tumours.

At the cell biology level, our interest focuses on signalling networks regulated by G - protein - coupled and growth factor receptors.

We hope to provide a more complete picture of the signalling network and to help find compounds beneficial in unravelling basic principles in signal transduction and, ultimately, in ion and enzyme secretion relevant to CF patients or in insulin secretion of s - cells.

In addition, we prepared a large number of tools to manipulate signalling networks and are able to locally activate the important messenger such as PIP3 and DAG with a light flash in subcellular resolution in living cells (Mentel et al. 2011; Nadler et al. 2013, Nadler et al. submitted).

The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan.