Sentences with phrase «tamoxifen works»

Tamoxifen works by blocking estrogen receptors in breast tissue.

Not exact matches

However, along with this seemingly linear storyline in which retinoids block progesterone's promotion of CK5 + cells, previous work in the lab of CU Cancer Center investigator Peter Kabos, MD, and others shows that breast cancers treated with anti-estrogen drugs like tamoxifen or aromatase inhibitors show an increased population of CK5 + cells — it is as if these therapies remove the roadblock of estrogen - dependent cells, leaving CK5 + cells to proliferate.

«This means that tamoxifen, which is probably the best therapy for breast cancer available, is not working solely through blocking the oestrogen receptors, which everyone thought it did.

«This work sets the stage for additional animal studies to see if tamoxifen can be used as a drug in people and will allow us to design new drugs related to tamoxifen that are better antifungals,» says Damian Krysan of the University of Rochester, an author on the study.

A team working at the Institute of Cancer Research and the Royal Marsden Hospital in London, in collaboration with scientists at the National Cancer Institute in Bethesda, Maryland, has found that tamoxifen also works by encouraging the cells surrounding a tumour to produce a «growth factor».

But recent work shows that while these cancers lack estrogen receptors, progesterone receptors, and aren't driven by the gene HER2, up to a third of these tumors express the androgen receptor — clinical trials are underway to inhibit the androgen receptor in these tumors in much the same way that the drug Tamoxifen inhibits estrogen receptor in estrogen - receptor - positive breast cancers.

Dr Julie Sharp, senior science information manager at Cancer Research UK, said: «These early results tell us more about why tamoxifen can stop working for some women.

I am confused by tamoxifen; I understand how it works, but why does a post menopausal woman have so much estrogen floating around?

Multiple other studies with mice have shown that dietary flaxseed works with tamoxifen to inhibit breast tumor growth.