Sentences with phrase «targeted gene expression profiling»
Using an array of techniques, including RNA sequencing and targeted gene expression profiling, the researchers searched for links between gene activity and protein production in these tumors and the clinical outcomes of patients.
https://www.ucsf.edu/ Not exact matches
The patterns of these polymorphic genes and their expression profiles comprise the molecular signatures of unique pathophenotypes, offering the promise of diagnostic, prognostic, and therapeutic specificity; the definition of disease becomes «personalized», as does its specific therapeutic targets.
The approach to target validation utilizes RNAi, CRISPR, and ORF expression platforms to genetically perturb candidate target gene expression in relevant cancer cell lines, and then profile the resulting phenotypic changes with regard to their effect on various biochemical pathways.
As outlined below, we used a microfluidic quantitative PCR (qPCR) system to elucidate the gene expression profiles of individual human oocytes and small numbers of cumulus cells using a combination of a large number of samples and targets [12], and then extended our studies via the use of parthenogenesis, in conjunction with gene expression profiling, as a functional assay of cytoplasmic maturation of oocytes.
With DriverMap, Cellecta offers a novel, comprehensive end - to - end service portfolio for identifying differential gene expression, mapping of clinically actionable mutations in RNA, detecting cellular composition, and profiling immunotherapy targets.
Dr. Loftus's research has gone on to detail how SOX10 and its downstream target gene MITF coordinately regulate gene expression profiles associated with melanocyte differentiation.
«Simultaneous mutation detection, copy number measurement, and digital gene expression profiling of high - grade serous ovarian cancer FFPE samples using Hyb & SeqTM targeted sequencing technology»
Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5
Robust prognostic gene signatures and therapeutic targets are difficult to derive from expression profiling because of the significant heterogeneity within breast cancer (BC) subtypes.
The new Driver - Map ™ Human Genome - Wide Gene Expression Profiling kit, is a targeted RNA expression profilExpression Profiling kit, is a targeted RNA expression profiliProfiling kit, is a targeted RNA expression profilexpression profilingprofiling assay.