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Targeted brain stimulation aids stroke recovery in mice, scientists find.»
As next steps, Dr. Meltzer will use these findings to explore
targeted brain stimulation that could boost the short - term memory of stroke patients.
Not exact matches
With further study, this regulatory network could be a more effective
target for epilepsy therapies, including implantable
stimulation devices that would help quiet a localized seizure before it spreads throughout the
brain.
Dr. Tsai said: «We implanted an intraventricular β - amyloid protein infusion pump and deep
brain stimulation electrodes over rats» skulls and achieved
target accuracy.
Deep -
brain stimulation involves the surgical placement of electrodes in the
brain to deliver
stimulation to
targeted areas that control movement, similar to the way pacemakers are used to maintain a healthy heart rate.
Researchers from Heidelberg University have developed a computer vision technique to analyse the changes in motor skills that result from
targeted stimulation of healthy areas of the
brain.
Transcranial magnetic
stimulation can stimulate
brain cells from outside the head, but is not highly
targeted and so affects large areas of the
brain at once.
Future
brain -
stimulation techniques could
target this bilateral effect in effort to promote communication between the hemispheres and, hopefully, engender healthy cognition throughout the lifespan.
Unlike its competitors, which use cranial electrotherapy or transcranial direct current
stimulation (tDCS), Thync doesn't directly
target the
brain.
Further, transcranial magnetic
stimulation isn't a precise tool for
targeting brain regions.
This coil permits the
targeted stimulation of areas of the
brain which, according to the latest research, play a major role in MS - associated fatigue.
In humans, this region could be a
target for bringing some
brain injury patients out of a comatose state via electrical stimulation, says lead author Nigel Pedersen, MD, assistant professor of neurology at Emory University School of Medicine and an epilepsy specialist at Emory Brain Health Ce
brain injury patients out of a comatose state via electrical
stimulation, says lead author Nigel Pedersen, MD, assistant professor of neurology at Emory University School of Medicine and an epilepsy specialist at Emory
Brain Health Ce
Brain Health Center.
TRPV1 channels are widely distributed throughout the human
brain, so another major challenge is figuring out how to deliver
stimulation only to the cells researchers want to
target, he adds.
Implanted devices send
targeted electrical
stimulation to the nervous system to interfere with abnormal
brain activity, and it is commonly assumed that neurons are the only important
brain cells that need to be stimulated by these devices.
His work suggests that deep -
brain stimulation — whether electrical or optical — may be most effective when it
targets not the neurons themselves but the connections between cells, thereby affecting the flow of activity between
brain regions.
Such studies could guide still - experimental therapies such as transcranial magnetic
stimulation, which aims to suppress or boost
brain activity in
targeted areas through electrical currents.
Scientists hope to ease the mental burden of diseases such as anxiety and post-traumatic stress disorder by selectively
targeting traumatic memories with behavioral therapy, drugs, ECT and milder forms of
brain stimulation.
The results suggest that, theoretically, delivering
targeted, selective, and specific
brain stimulation might improve some of the cognitive aspects of losing dopamine in Parkinson's disease.»
These findings open the door for researchers to potentially explore therapies that could
target this area of the
brain and disrupt its role in addiction, potentially with new drugs or other techniques such as deep
brain stimulation or transcranial magnetic
stimulation.
To conduct the study, Salas and her colleagues from the Department of Psychiatry and Behavioral Sciences and the Department of Physical Medicine and Rehabilitation used transcranial magnetic
stimulation (TMS), which painlessly and noninvasively delivers electromagnetic currents to precise locations in the
brain and can temporarily and safely disrupt the function of the
targeted area.
«Although different types of
brain stimulation are currently applied in different locations, we found that the targets used to treat the same disease are nodes in the same connected brain network,» says first author Michael D. Fox, MD, PhD, an investigator in the Berenson - Allen Center for Noninvasive Brain Stimulation and in the Parkinson's Disease and Movement Disorders Center at B
brain stimulation are currently applied in different locations, we found that the targets used to treat the same disease are nodes in the same connected brain network,» says first author Michael D. Fox, MD, PhD, an investigator in the Berenson - Allen Center for Noninvasive Brain Stimulation and in the Parkinson's Disease and Movement Disorders Cente
stimulation are currently applied in different locations, we found that the
targets used to treat the same disease are nodes in the same connected
brain network,» says first author Michael D. Fox, MD, PhD, an investigator in the Berenson - Allen Center for Noninvasive Brain Stimulation and in the Parkinson's Disease and Movement Disorders Center at B
brain network,» says first author Michael D. Fox, MD, PhD, an investigator in the Berenson - Allen Center for Noninvasive
Brain Stimulation and in the Parkinson's Disease and Movement Disorders Center at B
Brain Stimulation and in the Parkinson's Disease and Movement Disorders Cente
Stimulation and in the Parkinson's Disease and Movement Disorders Center at BIDMC.
Divided into two broad approaches, invasive and noninvasive,
brain stimulation works by
targeting specific sites to adjust
brain activity.
«This study illustrates the potential of gaining fundamental insights into
brain function while helping patients with debilitating diseases, and provides us with a powerful way of selecting
targets based on their connectivity to other regions that can be widely applied to help guide
brain stimulation therapy across multiple neurological and psychiatric disorders.»
One popular set of techniques, called transcranial electrical
stimulation (TES), delivers electrical current via electrodes stuck to the scalp, typically above the
target brain area.
The results of the study reveal that transcranial direct current
stimulation designed to simultaneously
target motor and cognitive regions apparently induces immediate aftereffects in the
brain that translate into reduced freezing of gait and improvements in executive function and mobility.»
«Neuronal
targets to restore movement in Parkinson's disease model: By using optogenetics to control neurons in the basal ganglia, researchers achieve effects that last longer than deep
brain stimulation.»
Bottom Line: Young mice that received molecularly
targeted therapies used to treat
brain cancer in human patients sustained cognitive and behavioral deficits, but the deficits were largely reversible through environmental
stimulation and physical exercise.
To extend the capabilities of this technology beneath the cortex, an optrode system for
targeted deep
brain stimulation and recording will be developed and integrated into the optical apparatus.
The findings help explain why the neural circuit identified is a promising
target for additional treatment development, including
brain stimulation therapies.
Transcranial magnetic
stimulation (TMS) is a non-invasive method of induction of a focal current in the
brain and transient modulation of the function of the
targeted cerebral cortex.
These results can be translated into a connectivity - based
targeting strategy for focal
brain stimulation that might be used to optimize clinical response.
«Several studies have
targeted the thalamus with deep
brain stimulation to treat Parkinson's, but the region's role in the disease was not well established,» adds Dr. Kreitzer, who is also an associate professor of physiology and neurology at UCSF.
Although optogenetics is not yet possible in humans, Dr. Paz believes we may be able to use similar therapies like deep
brain stimulation to
target a specific area in real time to stop a seizure.