Sentences with phrase «targeting tumour cell»
Identify and target tumour cells that remain dormant for many years after seemingly effective treatment
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To target liposomes to certain tissues or cells, such as tumour cells, a specific binder of a unique protein (an antigen) on the targeted cell, known as a monoclonal antibody, must be linked to the liposome surface.
This early stage research will explore how the virus targets stem cells and provide the starting point to develop new treatments that seek out the tumour and spare the surrounding healthy brain tissue.
Cardiff University scientists have developed a novel anti-cancer stem cell agent capable of targeting aggressive tumour forming cells common to breast, pancreas, colon and prostate cancers.
Around 15 per cent of women with breast cancer have this form of the disease, in which tumour cells lack the three receptors that most drugs target.
«Pancreatic cancer is extremely hard to treat by chemotherapy, so this finding is important because vitamin A targets the non-cancerous tissue and makes the existing chemotherapy more effective, killing the cancer cells and shrinking tumours.
A COMPOUND that slows the proliferation of triple - negative breast cancer cells in lab tests could lead to the first drugs to target this aggressive type of tumour.
Our data show that cancer cells without BRCA1 have more than one «Achilles heel,» and so there are more ways to target cancers and therefore to prevent tumours becoming resistant to treatment.»
The new device will allow for more accurate medical procedures that involve the use of ultrasound to kill tumours, loosen blood clots and deliver drugs into targeted cells.
If these could be targeted to tumours — by attaching them to antibodies that recognise cancer cells, for instance — it would then be possible to destroy the malignant cells» DNA using lower doses of radiation or drugs.
Professor Geoff Pilkington, study co-author and Head of the Brain Tumour Research Centre, said: «Although this work is still at an early stage, we have demonstrated key elements that are associated with tumour cell binding to blood vessels and this may provide a target for future drug development to prevent the development of secondary tumours in the Tumour Research Centre, said: «Although this work is still at an early stage, we have demonstrated key elements that are associated with tumour cell binding to blood vessels and this may provide a target for future drug development to prevent the development of secondary tumours in the tumour cell binding to blood vessels and this may provide a target for future drug development to prevent the development of secondary tumours in the brain.
Research fields are diverse, including basic research on cell proliferation, analysis of tumour cells and tissues to detect gene mutations, and identification of potential therapeutic targets in cancer.
A trained robotic surgeon experienced in the treatment of prostate, bladder and kidney cancer, Assoc Prof Chia said, «For anticancer drugs to achieve their best effectiveness, they need to penetrate into the tumour efficiently in order to reach the cystoplasm of all the cancer cells that are being targeted without affecting the normal cells.
«This is because the stress led to poor function against the cancer by T - cells, which are very important in the immune system's control and surveillance of tumours and are a major target in many immunotherapy treatments.»
Kasid said: «If the cells are targeted to the tumour, what additional effects would release of cytokines locally have on the tumour?»
The virus, code - named JX - 954, targets two genes involved in cancer cell growth and blood supply, which show increased activity in tumours.
In the future, scientists hope to target stem - cell - like cells within cancers that may be responsible for most of the growth of some tumours, and evade existing drugs.
«It suggests to us that targeting the pathways used in regulating cell fate decisions — how stem cells choose between cell proliferation and differentiation — could be a more effective way of halting tumours in their tracks and lead to potential new therapies.»
These drugs can be targeted to interfere with signalling within the tumour microenvironment or activate other processes which will kill the cancer cells.
We target tumours by exploring how the proteins found on the cancer cell surface can be utilised to inhibit growth or kill tumours.
If brain tumours are driven by neural stem cells with faulty developmental pathways, these transcription factors could potentially be good drug targets.
Willet, Mills, and their colleagues believe the discovery that cells in different organs go through the same process to become proliferative could lead to new potential targets for cancer treatment because the factors that initiate tumours could be the same in multiple organs.
«This looks like very clever technology which can specifically target and destroy tumour cells in this animal work.
Because tumour cells are more dependent than their normal neighbours on accelerated nutrient import, these up - regulated transporters could be excellent targets for selective anti-cancer therapies.
Even if you get most of the brain tumour out it comes back again, so we were wondering if you could leave something in the brain cavity that would help target chemotherapy precisely to the tumour to destroy the remaining tumour cells responsible for the disease coming back.
Tumour cells are «glutamine - addicted» [1,2] because glutamine is coupled to mechanistic target of rapamycin (mTOR) signalling, which integrates signals from growth factors, energy status and amino acid nutrition and co-ordinates these signals with cell growth, cell cycle progression and antioxidant machinery [3].
Kelley, lead investigator on the study published today in Nature Chemistry, explained how her team has advanced a completely new approach using magnetic nanoparticles with DNA capture probes on their surface that can target circulating tumour cells (CTCs) in blood samples to see if the cells contains biomarkers associated with drug resistance.
Targeting CTCs, the cells responsible for spreading cancer, is important because they carry information from the primary tumour that can inform treatment; however, they are outnumbered by a billion - to - one by normal cells in a patient» blood and are therefore extremely challenging to capture.
Areas of focus include: understanding how tumour - reactive T cells and B cells promote patient survival in cancer; defining the effects of standard treatments on tumor immunity; and using genomic approaches to identify novel tumour mutations that can serve as target antigens for immunotherapy.
Within the scope of personalized medicine, this technology presents immense possibilities for testing patient - derived multicellular tumour spheroids / organoids (comprising cancer cells, stromal cells, cancer stem cells and / or immune cells) for disease / biomarker - oriented drug activity and profiling using single - and pair-wise standard / targeted drug combinations.