Sentences with phrase «telomerase group»

This work, published in «Blood», was carried out by the CNIO Telomeres and Telomerase Group The treatment is based on the transport of the telomerase gene to the bone marrow cells using gene therapy, a completely new strategy in the treatment of aplastic anaemia

In 2012, the CNIO Telomeres and Telomerase Group, headed by Maria A. Blasco, came up with a strategy to repair telomeres.

Not exact matches

In the Zakian group, he focused on the PIFI gene, a telomerase inhibitor.

By 1985, Blackburn, who had started her own lab at UC Berkeley, and Carol Greider, a grad student in Blackburn's group, had discovered telomerase, an enzyme that synthesizes and preserves telomeric DNA.

The grueling 18 months unearthed a gold mine: Lundblad's team found three genes that are crucial for telomerase function, results that generated a flurry of groundbreaking papers from the members of her group in 1996 and 1997.

She was given lab space and funding to hire three Ph.D. students to start her own research group on telomerase activity, her salary being provided by El Consejo Superior de Investigaciones Científicas (the Spanish National Research Council).

By measuring telomerase activity, investigators determined that the group that smoked without drinking red wine showed a 56 % decrease in telomerase activity while the drinking group showed only a 20 % decrease.

Two independent groups of scientists have now linked some of these cases to mutations in genes encoding telomerase, an enzyme that protects the fragile ends of chromosomes, known as telomeres.

Using this assay, her group has identified a protein complex that inhibits telomere shortening while it promotes telomerase action.

Lundblad's group has engineered yeast cells that lack telomerase, to study how cells respond to eroding telomeres when telomerase is not present to counter-balance.

Various types of meditation have been shown to improve well - being among different populations such as physicians and the general public.14, 15, 16 Preliminary evidence suggests that meditation - based interventions may slow cellular aging rates by increasing telomerase activity, but many such studies lacked an active control group.17, 18 Recent randomized trials in breast cancer suggest that long - term intensive meditation interventions might have positive effects on telomerase activity.

Regular meditators had lower telomerase at baseline, but also showed a significant increase in peripheral blood mononuclear cell telomerase activity post treatment that was not observed in the other two groups.

We also identified a «meditation effect» within the regular meditator group, characterized by a distinct network of genes with cellular functions that may be relevant to healthy aging, and this network was associated with increased expression of a number of telomere maintenance pathway genes and an increase in measured telomerase enzymatic activity.

At the Shamatha Project, a three - month intensive meditation retreat, Blackburn and UC Davis researchers found telomerase activity in participants» white blood cells was one - third higher than in a control group's.

Of the two telomerase components analyzed, Tert (telomerase reverse transcriptase) expression did not show any differences between groups, but Terc (telomerase RNA component) transcription was significantly higher in the IVC testes (Fig. 2B).

Another is to monitor the effects of transplanting telomerase - deficient but ex vivo telomere - extended bone marrow into late - generation, TMM - disabled mice, so as to be certain that the niche of such animals (or, by implication, aging humans) will support the homing, engraftment, and initial development and differentiation of such cells; the necessary research is underway now thanks to a SENS Foundation grant to Dr. Zhenyu Ju of the Institute of Laboratory Animal Sciences and Max - Planck - Partner - Group on Stem Cell Aging in the Chinese Academy of Medical Sciences, and research partner of prominent telomere biologist Dr. K. Lenhard Rudolph.

From the same group studied above, Dr. Ornish measured the activity of an enzyme produced by genes, telomerase, believed to be involved in slowing the aging process.

Telomerase activity jumped 43 % in the meditation group compared to 4 % in a group asked just to relax for the same time period.

Dr. Dean Ornish worked with Dr. Elizabeth Blackburn, one of the recipients of the Nobel Prize, to measure telomerase activity in men who ate a low fat (< 10 % calories) plant based diet, walked daily, practice yoga and stress management, and attended support group meetings.

Some of the observed effects could be due to the relaxation response in both groups (e.g., improved depression), while the effects on cognitive and mental functioning and telomerase activity were specific to the Kirtan Kriya.»