Sentences with phrase «telomerase reverse»

Phenotypes in mTERT ⁺ / ⁻ and mTERT ⁻ / ⁻ mice are due to short telomeres, not telomere - independent functions of telomerase reverse transcriptase.

The strongest challenge to this approach, granting the periodic replenishment of somatic stem - cell pools with autologous but OncoSENS - ready stem cells, has been the possible existence of functions of TERT (telomerase reverse transcriptase — the catalytic subunit of telomerase), other than the lengthening of telomeres itself.

Of the two telomerase components analyzed, Tert (telomerase reverse transcriptase) expression did not show any differences between groups, but Terc (telomerase RNA component) transcription was significantly higher in the IVC testes (Fig. 2B).

Researchers at the Spanish National Cancer Research Centre (CNIO) published proof - of - principle results showing a role for telomerase reverse transcriptase (TERT)...

These cells were immortalized by retroviral transduction of the SV40 T antigen and Telomerase reverse transcriptase (TERT), the catalytic subunit of the telomerase complex [4], and then termed HMLE (Human Mammary with Large T and TERT).

Telomerase reverse transcriptase promoter mutations can cause high - level reactivation of the telomerase enzyme in bladder cancer.

In August, 1997, Nobelist Thomas Cech of the University of Colorado at Boulder and colleagues at Geron isolated the human gene for telomerase reverse transcriptase (hTRT)-- an enzyme that reknits loosening telomeres and extends a cell's life.

Variants in the gene called Telomerase Reverse Transcriptase (TERT) on chromosome 5 that were associated with older IEAA were also associated with longer telomeres indicating a critical role for TERT in regulating the epigenetic clock, in addition to its established role of compensating for cell replication - dependent telomere shortening.

Not exact matches

Pioneers like Dr Dean Ornish and Dr Caldwell Esselstyn where among the first to show that if you combined a low fat, plant based diet, with walking and stress management, not only could you prevent and reverse heart disease (and many other chronic conditions), but you could also increase telomerase activity.

Sequence comparisons placed the telomerase proteins in the reverse transcriptase family but revealed hallmarks that distinguish them from retroviral and retrotransposon relatives.

Catalytic protein subunits of telomerase from the ciliateEuplotes aediculatus and the yeast Saccharomyces cerevisiae contain reverse transcriptase motifs.

Thus, the proposed telomerase catalytic subunits are phylogenetically conserved and represent a deep branch in the evolution of reverse transcriptases.

Understanding the regulation and limitation of the telomerase enzyme holds the promise of reversing telomere shortening and cellular aging with the potential to extend human lifespan and improve the health and wellness of elderly individuals.

Counteracting the telomere shrinking process is the enzyme, telomerase, that uniquely holds the key to delaying or even reversing the cellular aging process.

The scientists speculated that when chromosome tips get too stubby — a process that can be reversed by telomerase, an enzyme made up of protein and RNA — cells cease replicating and enter a state called senescence (see» More Than a Sum of Our Cells»).

Arsenic, the researchers found, stops a gene for an important part of the telomerase enzyme, known as the reverse transcriptase subunit, from being translated.

The Nobel Prize in Medicine was awarded to three scientists in 2009 for describing an enzyme, telomerase, that can add length to telomeres and holds the potential to slow or reverse aging.

You'd probably think I was running an infomercial if I told you about a simple intervention that: Reverses memory loss Increases energy levels Improves sleep quality Up regulates positive genes Down regulates inflammatory genes Reduces stress in patient and caregiver Improves psychological and spiritual well being Activates significant anatomical areas of the brain Increases telomerase,