Sentences with phrase «tfh cell response»
The Tfh cell response to vaccination is greatest during the first trimester of pregnancy.
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The findings were published online today in the journal Immunity in a paper entitled, «Human circulating PD - 1 + CXCR3 - CXCR5 + memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses.»
Crotty says the ability to measure Tfh cells in the blood will assist AIDS vaccine researchers by serving as an indicator of antibody response.
«We've shown that a specific type of these cells, known as follicular helper T (Tfh) cells are not only necessary, but are a limiting factor that differentiates between an average and a potent antibody response to HIV,» says Crotty, a scientific collaborator with the Center for HIV / AIDS Vaccine Immunology & Immunogen Discovery (CHAVI - ID), a major research consortium led by The Scripps Research Institute.
Further, the study showed a direct correlation between levels of Tfh cells and antibody response.
«The higher the levels of Tfh cells, the more significant the antibody response,» says Crotty.
Vaccine immunology is poorly understood in pregnancy and Tfh cell expansion has been shown to be a predictor of response to influenza vaccination outside of pregnancy.
In their latest study, researchers at La Jolla Institute for Allergy and Immunology identified a key signal that drives the commitment of immature Tfh cells into fully functional Tfh cells and thus driving the step - by - step process that results in a precisely tailored and effective immune response.
«Tfh cells have recently been recognized as important players in the immune system, and we now know they are essential for almost all antibody responses,» said Crotty.