EOS100850 potently rescues Th1 cytokine production in human whole blood treated by A2A agonists, and increased CD8 + T cell cytotoxicity in a co-culture assay of effector CD8 + T cells and target cancer cells
VPA downregulated Th1 and Th17 cell responses and cytokineproduction in vitro and in vivo, whereas its effect on GVHD was regulatory T cell independent.