In January 2004, a group of respected investigators wrote to Science voicing their concern about the wisdom of the US government in sponsoring
the Thai vaccine trial.
In 2009, the RV144
Thai vaccine trial provided the first evidence in humans that a safe and effective preventive HIV vaccine is possible.
Not exact matches
Costing $ 105 million and enrolling more than 16,000 subjects, the
Thai clinical
trial was the largest AIDS
vaccine test to date.
The long - awaited
trials have the backing of the
Thai government and the WHO, and the
vaccine's safety has been thoroughly tested in the US.
The row over the
Thai trials has been fuelled by an explosive mix of factors, including the pace at which the HIV epidemic is growing in Asia, the future of the
vaccines industry, and domestic tensions in the US between AIDS researchers, activists and politicians.
The event included a scientific lecture on
Thai HIV
vaccine trial (RV 144) and presentations on milestones achieved over the decade (2002 — 2012) in the different programs.
The panel discussed progress that's been made including the follow - up to the RV144
Thai prime - boost
trial results and in the development of the next generation of
vaccine candidates for testing.
Many scientists believe that the
Thai HIV
vaccine trial, which had recruited over 2,500 of its projected 16,000 participants by June 2004, has no chance of success.4 Yet the investigators overseeing the study (who include American scientists), the local
Thai institutional review boards, and the
Thai Ministry of Health have all remained silent — at least on the record.
At the AIDS
Vaccine conference in Bangkok on Tuesday, scientists announced an update to a Thai trial of a «modestly effective» experimental AIDS v
Vaccine conference in Bangkok on Tuesday, scientists announced an update to a
Thai trial of a «modestly effective» experimental AIDS
vaccinevaccine.
It played a critical role landmark RV144 «
Thai Study,» a 16,000 person study which was the only HIV
vaccine trial to date to demonstrate modest (31 %) efficacy of a potential HIV
vaccine, and the follow - on studies on the RV144 correlates of risk.
Immunogenicity of ALVAC - HIV (vCP1521) and AIDSVAX B / E Prime Boost Vaccination in RV144,
Thai Phase III HIV
Vaccine Trial
Glenda Gray, executive director of the Wits Health Consortium's perinatal HIV research unit in South Africa, presented data today at the HIV R4P conference in Cape Town indicating that the prime - boost
vaccine candidates initially tested in the RV144
trial in Thailand — the only HIV
vaccine trial to date to show any efficacy — induced cross-clade immune responses in a Phase I safety
trial conducted in South Africa, with immunogenicity similar to or greater than that of the responses induced in
Thai volunteers.