Sentences with phrase «therapeutic cell production»
Dr. Thinle Chodon was recruited in September 2013 as an Assistant Member and Associate Director of the Therapeutic Cell Production Facility (TCPF) at the Center For Immunotherapy (CFI).
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«Cells have the capacity to regulate protein production to suit demand, and offer considerable advantages over periodic injections of therapeutic proteins,» he said.
The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions cells use to produce it.
Their work could overcome a stumbling block for gene therapy by ensuring that a gene is actually inserted into a target cell's chromosome, where it will order the production of therapeutic proteins.
Non-exclusive licenses are available for research and sale of products and services across multiple fields including: research tools, kits, reagents; discovery of novel targets for therapeutic intervention; cell lines for discovery and screening of novel drug candidates; GMP production of healthcare products; production of industrial materials such as enzymes, biofuels and chemicals; and synthetic biology.
Therapeutic applications of CRISPR - Cas gene editing are being advanced with the goals of finding cures and treatments for a range of serious diseases, developing needed medicines for both household pets and production animals, and improving cell culture systems for bioproduction.
«The discovery that aldose reductase regulates mucus production and goblet cell metaplasia makes inhibition of this enzyme an attractive therapeutic option to reduce mucus - related airway obstructive diseases — and for the first time gives us a real chance to alter the course of the underlying disease in asthma and COPD.»
Asterias maintains an extensive global intellectual property portfolio including broad issued claims to fundamental platform technologies including, but not limited to, scalable growth of pluripotent stem cells, methods of production and compositions of matter for several hESC - derived therapeutic cell types, and cellular immunotherapy using the telomerase antigen.
By delivering mRNA drugs via IV to the liver, and directing liver cells to express functional proteins, Moderna can potentially stimulate production of therapeutic proteins in ways that can not be achieved with other current technologies.
However, suspension - adapted production cell lines cultured in large - scale bioreactors are more amenable to therapeutic product expression because of their enhanced scalability and elimination of detachment agents, which facilitates regulatory compliance.
Zinc finger technology is one of the hottest areas now in everything from gene therapy for HIV to increasing crop yield, to therapeutic protein production, to the great hope for stem cell therapy.
Furthermore, the finding that blood cells can be used to derive iPS cells [78] may remove the need for invasive patient biopsies required for the collection of somatic cells and accelerate the ethical production of stem cell - derived tissue for therapeutic use.
The therapeutic dotential of dietary precursor modulation by a fish - oil - supplemented diet (n - 3 fatty acids), such as eicosapentaenoic acid (C20: 5,n - 3) and docosahexaenoic acid (C22: 6,n - 3) in the therapy of ulcerative colitis has been shown to result in a 35 % to 50 % decrease in neutrophil production of LTB4.28 Significant improvement in symptoms and histologic appearance of the rectal mucosa has been observed in several small series of patients with Crohn's disease and ulcerative colitis given fish oil at 3 to 4 g daily for 2 to 6 months in uncontrolled studies.29 However, a larger, randomized, double - blind trial comprising 96 patients with ulcerative colitis failed to reveal any benefit in remission maintenance or treatment of relapse on 4.5 g of eicosapentaenoic acid daily, despite a significant reduction in LTB4 synthesis by blood peripheral polymorphonuclear cells.30 It should be emphasized, however, that the anti-inflammatory actions of the fish oils, in addition to inhibition of LTB4, include suppression of IL - 1 and platelet activating factor synthesis and scavenging of free oxygen radicals.30 The impact of increased lipid peroxidation after fish oil supplementation should be considered when altering the n - 6: n - 3 fatty acid ratio.31 Antioxidant supplementation may be able to counteract the potentially adverse effects of n - 3 fatty acids.