Top Ten Clinical Research Achievement Award Re-engineering Chimeric Antigen Receptor T Cells for Targeted
Therapy of Autoimmunity
Dr. Payne and colleagues have devised an exceptionally innovative approach to re-engineer chimeric antigen receptor (CAR) T cells for
therapy of autoimmunity.
Not exact matches
Antigen - specific
therapy using insulin before the development
of autoantibodies may induce protective immune responses that prevent the emergence
of autoimmunity and subsequent type 1 diabetes in genetically at - risk children, according to background information in the article.
His laboratory harnesses the tools
of synthetic and chemical biology to engineer the immune cell
therapies for cancer and
autoimmunity of the future.
In the last decade, Foxp3 + Treg cells have raised the hope for novel cell - based
therapies to achieve tolerance in clinical settings
of unwanted immune responses such as
autoimmunity and graft rejection.
For antigen induced tolerance to be effective, combination
therapies may also include an anti-inflammatory drug to create the appropriate environment for sustained suppression
of autoimmunity.
Already on this post is the work
of Dr. Yehuda Shoenfeld, MD, «The Mosaic
of Autoimmunity: Prediction, Autoantibodies, and
Therapy in Autoimmune Diseases — 2008» located at http://www.ima.org.il/FilesUpload/IMAJ/0/42/21035.pdf paper (from the Gluten Summit) and which is already cited on some
of my tagged «microbiome» posts and the most recent «ALZHEIMER»S, DIET - MICROBIOME, & BIO-MARKER PREDICTORS» posting, http://biomeonboardawareness.com/alzheimers-diet-microbiome-bio-marker-predictors/
Up to 50 million Americans are estimated to have an autoimmune condition, * and annual direct healthcare treatment costs for these patients total $ 100 billion.1 Nearly 100 different diseases have been classified as autoimmune in nature, with 40 more suspected.1 IFM's 2018 Annual International Conference (AIC), «Solving the Puzzle
of Autoimmunity: The Interplay
of Gut, Genes, and Environment,» focuses on the exploding research and
therapies around the interconnected roles
of intestinal permeability, genetic disruptors, and various environmental triggers that coalesce to create autoimmune disease.