Sentences with phrase «transcriptional factor foxo3a»

Histone demethylase JMJD2A regulates Kaposi's sarcoma - associated herpesvirus replication and is targeted by a viral transcriptional factor.

A new study involving roundworms appears to have isolated one gene — a transcriptional factor (or gene that controls the regulation of other genes in the genome)-- that appears to be an essential member of the pathway that translates reduced caloric intake into a longer life span.

«We have shown that the synthesis of nitric oxide (NO), known to regulate gut motility functions and NRF2, a transcriptional factor known to regulate several antioxidant genes, mediated Phase II protein expression have been altered in colon specimens of polybacterialinfected ApoE - / - mice,» said Miriam Walker.

After receiving her Ph.D. in immunology from the Open University, United Kingdom, where she researched the identification of transcriptional factors regulating the unique phenotype of the human blood — brain barrier, she joined the Roche Brain Shuttle program as a postdoctoral fellow.

Dillin's team then screened 15 other genes from the forkhead family — transcriptional factors important to development and possibly longevity, to which the gene for daf - 16 belongs — to see if any of them were necessary to increase longevity after dietary restriction.

Using this strategy, Cas9 is able to deliver transcriptional factors to specific genes and regulate their expression.

Hsiou - Chi Liou and colleagues find that c - Rel, a lymphoid - specific member of the NF - kappaB / Rel family of transcriptional factors, is essential for B lymphocyte survival and cell cycle progression, [i] and that it is important for inducible cytokine and cytokine receptor expression and a key regulator of early activation and proliferation in T cells.

In parallel, the mRNA expression of key transcriptional factors for Th1 cells (T - bet), Th17 cells (Rorc), and Tregs (Foxp3), as well as Ifng and Il17a, also were decreased in a dose - dependent manner (Supplemental Fig. 4D).

In this study, we develop a reproducible protocol for efficient reprogramming mouse neural progenitor cells (NPCs) on human foreskin fibroblast (HFF) cells via retroviral transfer of human transcriptional factors OCT4 / SOX2 / KLF4 / C - MYC.

These include: a) Global Clusters that consist of a small, tight subset of genes that are co-expressed under the entire spectrum of experimental conditions; b) Time Series of gene expression profiles during successive days of standard ES cell differentiation; c) Specific Gene Classes based on hierarchical clustering of transcriptional factors and ESTs; d) Expression Waves of genes with characteristic expression profiles during ES cell differentiation, juxtaposed to waves of genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES database clusters.

Evidence from animal studies has suggested that PFASs may be involved in altering energy metabolism and thyroid hormone homeostasis [15 — 17], likely through the activation of various transcriptional factors, such as the peroxisome proliferator - activated receptors (PPARs)[18 — 20].

Not exact matches

She and her colleagues knew that chromatin regulators — which control how genetic material gains access to a cell's transcriptional machinery — were key to treating the social deficits in ASD, but the challenge was to know how to affect key risk factors at once.

The MECP2 gene encodes methyl - CpG - binding protein - 2 (MeCP2), a transcriptional regulator of many genes including brain - derived neurotrophic factor (BDNF).

«Because transcription factors have proven so difficult to block with targeted therapies, we wanted to see if an alternative approach that targets these defective transcriptional mechanisms would be effective.»

Using computational methods, researchers applied that information to reconstruct the transcription factor networks responsible for medulloblastoma subtype diversity and identity, providing previously unknown insights into the regulatory landscape and transcriptional output of the different medulloblastoma subtypes.

We identified a protective mechanism that is controlled by the transcription factor ARNT, which effectively inhibits progression of chronic kidney injury by transcriptional induction of ALK3, the principal mediator of anti-fibrotic and pro-regenerative BMP signaling responses.

Pivotal role of cardiac lineage protein - 1 (CLP - 1) in transcriptional elongation factor P - TEFb complex formation in cardiac hypertrophy.

Ellen V. Rothenberg and Susan B. Ward report that the interleukin - 2 (IL - 2) transcriptional apparatus integrates multiple types of biochemical information in determining whether or not the gene will be expressed, using multiple diverse transcription factors that are each optimally activated or inhibited by different signaling pathways.

Our results suggest that the lipid - activated transcription factor PPARγ orchestrates a transcriptional response leading to the development of a dendritic cell subtype with increased internalizing capacity, efficient lipid presentation, and augmented potential to activate iNKT cells.

Transforming growth factor β / Smad3 signaling regulates IRF - 7 function and transcriptional activation of the β interferon promoter.

The transcriptional regulator megakaryoblastic leukemia - 1 mediates serum response factor - independent activation of tenascin - C transcription by mechanical stress.

In addition to p53, there are other transcriptional activatory mechanisms that are not well understood for the most part and which operate in response to mitogenic stimulation (11, 12), transforming growth factor - β (13, 14, 15), and aberrant oncogenic signals (16, 17) or during a number of cell differentiation processes (18, 19).

Additionally, the drug was shown to inhibit the TRAF2 - and NCK - interacting kinase (TNIK), a regulatory component of the β - catenin and T - cell factor - 4 (TCF - 4) transcriptional complex downstream of the adenomatous polyposis coli (APC) gene product in colon cancer [30].

The cellular transcription factor NF - kB consists of two DNA - binding subunits of 50K and 65K and is believed to play an important role in stimulating transcriptional activation of HIV - 1 in latently infected T - cells

The supernatant of apoptotic cells causes transcriptional activation of hypoxia - inducible factor — 1α in macrophages via sphingosine -1-phosphate and transforming growth factor - β.

In the absence of Wnt signaling, we found that Tcf factors associate with proteins of the Groucho family of transcriptional repressors to repress target gene transcription.

Direct Transcriptional Up - regulation of Cyclooxygenase - 2 by Hypoxia - Inducible Factor (HIF)-1 Promotes Colorectal Tumor Cell Survival and Enhances HIF - 1 Transcriptional Activity during Hypoxia

They may exert a transcriptional function or act as comodulators for other transcription factors.

IRE1 is a serine / threonine protein kinase and endoribonuclease that signals transcriptional activation by initiating a novel splicing reaction on the mRNA encoding the transcription factor XBP1.

These include molecular evolution of transcription factors or changes in transcriptional regulation (Enard et al., 2002; Konopka et al., 2009), accelerated evolution of small non-coding RNAs (Pollard et al., 2006), changes in the tissue - specificity of enhancer elements (McLean et al., 2011; Prabhakar et al., 2008), or changes in patterns of alternative splicing of specific genes (Calarco et al., 2007).

Thus, a dual mechanism including the involvement of ATP hydrolysis and recruitment of other transcription factors (e.g., Sp1) would seem to occur with DDX3 - mediated transcriptional regulation.

Among transcripts that were decreased in ABL1 / ABL2 knockdown cells were TAZ [also known as WWTR1 (WW domain — containing transcription regulator protein 1)-RSB-, which encodes a transcriptional coactivator in the Hippo pathway, and STAT5A, which encodes a transcription factor (Fig. 6C).

Overall, this study highlights the close links between transcription factor - driven genome topology dynamics, chromatin state, and gene expression and highlights a critical role for genome topology in enforcing transcriptional programs and cell fate.

Thus, SOX9 expression in chondrocytes involves various transcriptional modules regulated by SOX9 itself and by other factors.

In particular, understanding how transcription factors (TFs) bind in a sequence specific manner to the DNA and how the alteration of transcriptional regulation contributes to cancer.

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

The transcriptional program of early embryonic development is tightly regulated by a set of well - defined transcription factors that suppress premature expression of differentiation genes and sustain the pluripotent identity.

Factors such as local sequence context, replication timing, transcriptional status or paternal age at conception are known to bias the occurrence of spontaneous mutations.

The pathways that connect expression of stem cell surface glycoconjugates such as the TRA -1-60 / GCTM - 2 antigen, receptors, and growth factors in human and even mouse ES cells with the transcriptional networks that regulate pluripotency remain unclear.

For instance, the mono - allelic expression of imprinted genes shows that two alleles exposed to the same transcription factors can have opposite transcriptional states.

In breast cancer cells, the ABL kinases activated the transcriptional coactivator TAZ and the transcription factor STAT5, which triggered the transcription of genes encoding factors that activate osteoclasts (cells that break down bone) and those that enhance the survival of breast cancer cells in the bone microenvironment.

Antagonistic Basic Helix - Loop - Helix / bZIP Transcription Factors Form Transcriptional Modules That Integrate Light and Reactive Oxygen Species Signaling in Arabidopsis

This elongation factor encourages the transcriptional elongation step by adding phosphate groups onto RNA Polymerase II and by outcompeting other proteins that act to stop the process.

Ortiz, Lourdes, et al. «Transcriptional control of the forkhead thyroid transcription factor TTF - 2 by thyrotropin, insulin, and insulin - like growth factor I.» Journal of Biological Chemistry 272.37 (1997): 23334 - 23339.

Another important factor in reading and writing disabilities, READ1, a polymorphic compound with a short tandem repeat within intron 2 of risk gene DCDC2 may have a non-additive genetic interaction with KIAHap, a risk haplotype in risk gene KIAA0319 may be a transcriptional regulator of ETV and so also a transcriptional regulator of KIAA0319.