The Initiation Codon Determines the Efficiency but Not the Site of
Translation Initiation in Chlamydomonas Chloroplasts
Ilona Kats is a graduate student in the Neuroscience program interested in the mechanism of cap - dependent
translation initiation in autism and synaptic plasticity.
Not exact matches
The
initiation service or puja is
in Sanskrit, with
translation forbidden.
The role of miRNAs and of their close cousins small interfering RNAs (siRNAs)
in RNA silencing is discussed by Zamore and Haley (p. 1519), and illustrated
in the poster pullout
in this issue and
in research showing that miRNAs can repress the
initiation of
translation (p. 1573) and, intriguingly, can also increase mRNA abundance (p. 1577).
Interest
in studying tRNA fragments has been increasing swiftly as studies have shown that the fragments have regulatory roles and implicated individual fragments
in cellular processes such as
translation initiation, response to viral infection, response to DNA damage, etc..
«These RNA molecules will fold into shapes that appear to mimic some of the
initiation factors that that you would find
in eukaryotic
translation,» he says.
The mechanism of action for
translation enhancing elements is still obscure, particularly
in the case of internal ribosomal
initiation sites.
Both assays (for
translation enhancement and internal ribosomal
initiation) were validated under cell - free conditions and
in human cells, using a vaccinia virus vector.
Roughly 20 percent of the
translation enhancing elements functioned as internal ribosomal
initiation sites, again turning up primarily
in non-coding genomic regions.
This includes how subtle changes
in gene sequences can impact the expression of encoded proteins through mechanisms including codon bias, mRNA stability, and
translation initiation.
Our laboratory has spent many years delineating the regulation of
translation initiation by the mTORC1 and ERK signaling cascades during LTP, LTD, and memory formation
in the hippocampus.
In a second scheme, transcription activator - like effector nucleases (TALENs) were targeted to sequences near the translation - initiation site of CCHa2 - R to create a frame - shift mutation in the CCHa2 - R coding region [24
In a second scheme, transcription activator - like effector nucleases (TALENs) were targeted to sequences near the
translation -
initiation site of CCHa2 - R to create a frame - shift mutation
in the CCHa2 - R coding region [24
in the CCHa2 - R coding region [24].
Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule
in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1,
translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R,
Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched
in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting
What they all have
in common is the ability to spark
translation initiation independent of the 5» cap.
Ostroff LE, Botsford B, Gindina S, Cowansage KK, LeDoux JE, Klann E, Hoeffer C. (2017) Accumulation of Polyribosomes
in Dendritic Spine Heads, But Not Bases and Necks, during Memory Consolidation Depends on Cap - Dependent
Translation Initiation.
Leucine regulates
translation initiation of protein synthesis
in skeletal muscle after exercise.
HMB stimulates protein synthesis
in muscle by multiple mechanisms, including the mTOR / p70S6k pathway, which stimulates
translation initiation of protein synthesis.
Leucine supplementation of a low - protein meal increases skeletal muscle and visceral tissue protein synthesis
in neonatal pigs by stimulating mTOR - dependent
translation initiation