Sentences with phrase «translimbal trabecular»

Zimmer Biomet announced the completion of the first surgical case utilizing its Persona Trabecular Metal (TM) Tibia.

When myocilin goes wrong, or «misfolds,» it makes fibrils that damage tissue called the trabecular meshwork that normally allows the fluid inside the eye to drain and relieve interior pressure.

«When a myocilin propellor misfolds, it unravels and forms amyloid fibrils (stringy abnormal proteins) that kill cells that maintain the trabecular network,» Lieberman said.

Additionally, the diabetic mice had considerably lower spongy bone mass, known as trabecular bone, making it easy to fracture.

Its impact appears to reduce the ability of the cells in the eye's trabecular meshwork to continually move the clear aqueous humor out of the front of the eye and dump it into the body's general circulation, said Liu, corresponding author of the study in the journal Investigative Ophthalmology & Visual Science.

He's also looking at the impact on the ability of trabecular meshwork cells to make and send out fluid - filled pockets called exosomes that may enable the cells to communicate.

The additional insight will help answer questions like whether trabecular meshwork cells become stiff and less capable of making the pores that let fluid come onboard for their endless transport task as Liu suspects.

Now, they are also are looking at the impact on the trabecular meshwork cells» ability to take up aqueous humor and deliver it back to the circulation.

TIGR is made by the eye's trabecular meshwork cells, which help regulate eye pressure by controlling the drainage of fluid from the eye as new fluid is produced.

The small increase in the high - dose group did not translate into beneficial effects because authors found no difference between the three study groups for changes in spine, average total - hip, average femoral neck or total - body bone mineral density, trabecular bone score, muscle mass or sit - to - stand tests.

Researchers determined distal radius cortical and trabecular bone microstructure by HR - pQCT, together with areal BMD (aBMD) by DXA.

Based on the scan results, the women were assigned a Trabecular Bone Score assessing the quality of their underlying bone structure.

Natural materials, such as trabecular bone and the toes of geckoes, have evolved with multiple levels 3 - D architectures spanning from the nanoscale to the macroscale.

When the team scanned hand bones from four members of A. africanus that lived in South Africa between 2 million and 3 million years ago, they found that the pattern of the trabecular bone was asymmetrical, as in modern humans and Neandertals that use tools frequently (as they also show in their study).

Gripping a tool distributes forces asymmetrically along the base of the thumb and the side of the knucklebones, and modern hands show a corresponding pattern of trabecular density.

One innovative aspect of the study was the measurement of bone texture of the lumbar spine using trabecular bone score (TBS)- the first use of this technique in adolescent athletes.

Discussion: Overall, quantified trabecular parameters represent overall differences in bone strength between the two species, however, DA may be directly related to joint loading.

Trabecular architecture in the thumb of Pan and Homo: implications for investigating hand use, loading, and hand preference in the fossil record

Traditional analyses have quantified cortical or trabecular structure in only selected regions of a bone, such as single cross-sections of cortical bone or volumes of interest of trabecular structure in epiphyses.

Materials and methods: We apply a whole - bone / epiphysis approach to analyze trabecular and cortical bone in the distal tibia and talus of Pan troglodytes and Homo sapiens.

Objectives: Internal bone structure, both cortical and trabecular bone, remodels in response to loading and may provide important information regarding behavior.

We quantify bone volume fraction (BV / TV), degree of anisotropy (DA), trabecular thickness (Tb.Th), bone surface to volume ratio (BS / BV), and cortical thickness and investigate the distribution of BV / TV and cortical thickness throughout the bone / epiphysis.

Recently published findings suggest that WBV increases trabecular and cortical bone mass in db / db mice (44), but these effects differ from the modest skeletal responses observed after exercise and WBV in the current study.

The research, titled «Human - like hand use in Australopithecus africanus, shows that Australopithecus africanus,» a 3 - 2 million - year - old species from South Africa traditionally considered not to have engaged in habitual tool manufacture, has a human - like trabecular bone pattern in the bones of the thumb and palm (the metacarpals) consistent with forceful opposition of the thumb and fingers typically adopted during tool use.

Here we show that Australopithecus africanus (~ 3 to 2 million years ago) and several Pleistocene hominins, traditionally considered not to have engaged in habitual tool manufacture, have a human - like trabecular bone pattern in the metacarpals consistent with forceful opposition of the thumb and fingers typically adopted during tool use.

Using automated morphological filters, the cortical bone is defined and extracted from the underlying trabecular structure to create two 3D models, one of the cortex and one of the trabecular bone that can be analysed separately.

The trabecular structure of the talus is more divergent than the tibia, having thicker, less uniformly aligned trabeculae in Pan compared to Homo.

Differences in dorsiflexion at the talocrural joint and in degree of mobility at the talonavicular joint are reflected in the distribution of cortical and trabecular bone.

Trabecular bone remodels quickly during life and can reflect the actual behaviour of individuals in their lifetime.

We test the sensitivity of the morphological parameters used to create these 3D models, demonstrating that the parameters defined here are robust and can provide accurate measures of cortical thickness, relative bone density, trabecular orientation, trabecular thickness and degree of anisotropy.

Cortical and trabecular bone distributions correlate with habitual joint positions adopted by each species, and thus have potential for interpreting joint position in fossil hominoids.

Other data obtained in this report (BrdU nitroblue tetrazolium staining by alkaline phosphatase and fluorescence due to fluorescein) would further suggest that putative stem cells are located in the posterior limbus between the peripheral endothelium and the trabecular meshwork.

The area of the trabecular meshwork and its surrounding posterior limbus in the human, however, showed considerable fluorescence indicative of cell division (Figure 6B).

Conclusions: It is suggested stem - like cells may be sequestered in a niche at the junctional region where the corneal endothelial cells and the trabecular meshwork come together.

No activity was observed in the central endothelial tissues or the limbus between the trabecular meshwork and Schwalbe's line.

In this report, no telomerase activity in the limbal region from Schwalbe's line to the trabecular meshwork was detected.

The effect of glucocorticoid treatment is most prominent on trabecular bone and is therefore likely to be larger on vertebral bone than on hip bone.3 Glucocorticoids are associated with an increased rate of fracture, and higher doses and longer use of glucocorticoids are associated with higher risks of fracture.4 Compared with patients not taking glucocorticoids, the risk of hip and vertebral fracture among patients taking glucocorticoids is increased by 60 % and 160 %, respectively.4 Among 80 - year - old patients, the hip fracture risk is increased by a magnitude of 2.1 and is independent of BMD.5 Most studies indicate that fracture risk is increased following at least 3 months of treatment with daily doses of 5 mg of prednisolone or more in older men and women.4

There was also increased fluorescence in the area of the trabecular meshwork and posterior limbus of greater magnitude than in the unwounded condition (Figure 7B).

However, we have found a fluorescent marker for nestin, a neural crest stem cell marker, in the posterior limbal region of the human anterior segment in the vicinity of both the trabecular meshwork and Schwalbe's line (unpublished).

Branching, transparent tube - like structures that match the porosity of the trabecular bone.

When BrdU fluorescence assays were made on corneal transverse sections with fluorescein, fluorescence occurred in an area just at and adjacent to the trabecular meshwork, but was not seen at the corneal endothelium.

Figure 8A shows the concave surface of a vascular canal in trabecular bone.

By way of contrast, considerable fluorescence was observed in the area of the trabecular meshwork and the posterior limbus (Figure 6B).

Comparison of the differentiation potential of cell populations isolated from human lipoaspirate, trabecular bone tissue and periosteal tissue.

The authors say that it's possible that the new trabecular meshwork cells generated from the stem cell treatment could eventually succumb to the same mechanisms that caused the fluid buildup in the first place, but further research is needed in that area.

These tissues include the trabecular meshwork, which composes the drain of the eye and regulates intraocular pressure, and the optic nerve, which transmits visual information from the eye to the brain.

ICS offers new capabilities for analysing bone dynamics including both in vivo and ex vivo analysis of trabecular and cortical bone structures by MicroCT.

Summary: Patients with primary open - angle glaucoma (POAG) often present with chronically elevated intraocular pressure (IOP), the result of increased resistance to aqueous humor outflow through the trabecular meshwork.

Project: Nanoengineered In Vitro Trabecular Meshwork ™ Model for Systematic Investigation of Aqueous Humor Outflow Resistance

Carla J. Siegfried, MD Washington University School of Medicine, St. Louis, MO Funded by The Alcon Foundation Project: Pathological Alterations in the Trabecular Meshwork Following Vitrectomy and Lens Extraction: A Model of Oxidative Stress