«
Treating axonal degeneration could potentially help a lot of patients because there are so many diseases and conditions where axons are inappropriately lost,» said Aaron DiAntonio, MD, PhD, professor of developmental biology.
«
Treating axonal degeneration could potentially help a lot of patients because there are so many diseases and conditions where axons are inappropriately lost,» says Aaron DiAntonio, MD, PhD, professor of developmental biology.
Not exact matches
This new study builds on previous research from this group showing that elevated blood levels of SNTF on the day of a mild traumatic brain injury
treated in the emergency room predicted those patients who would go on to suffer diffuse
axonal injury and long - term cognitive dysfunction.
Necrostatin - 1 not only restored the myelin sheath and stopped
axonal damage but also prevented limb weakness in animals
treated with it.
In a final set of experiments, the researchers used necrostatin - 1 to
treat mice with
axonal damage and hind leg weakness, a telltale sign of
axonal demise similar to the muscle weakness that occurs in the early stages of ALS in humans.
When it is experimentally prevented (either by severing the projecting axons, by
treating them with the drug vinblastine, which blocks
axonal transport, or by administering 6 - hydroxydopamine, which destroys the nerve endings), the innervating sympathetic neurons in the ganglion die off.