Sentences with phrase «trial strategies for»

«Trial Strategies for Holding Trucking Companies Responsible for their Employees» Negligent Conduct,» Illinois Trial Journal, Summer 2012.

Attorneys will also recognize a trial strategy for examining and cross-examining experts in these cases.

We will cover not only what PA and PAS is, but provide some suggestion as to how to develop a trial strategy for cases that involve these disorders.

Participants will also be able to distinguish between alienation and alleged abuse and how to develop a trial strategy for cases that involve these disorders.

Not exact matches

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

All those failures, trials and errors, however, culminated in his three - pronged management strategy for making the transition from working «in» a business to working «on» a business.

As other boards use HP as a case study and learn from its trials, perhaps it's time for HP to also re-examine the board's level of involvement with the company's strategy — before the company presents their ideas to the public.

On its own, this strategy likely won't satisfy even long - term shareholders, and in its time of trial Talisman has picked up some shorter - term players with a penchant for shareholder activism.

In those areas that we have mapped, it typically takes us a few hours to go from a mechanism - inspired idea for treating a disease to knowing the companies that might have relevant clinical and preclinical assets to license, the companies from whom a candidate could be commissioned, trial designs and endpoints, competing and complementary agents, current and future standard of care, market size, comparable pricing, financing strategy, and potential acquirers, all meant to enable a thoughtful first - pass assessment of whether an idea could be worth a much deeper assessment.

Clinical Trials Ontario is an independent not - for - profit organization that has been established through the Ministry of Research and Innovation as part of Ontario's Life Sciences Commercialization Strategy.

In fact Bar - Ilan University in Israel has already begun trial tests for using nanobots as a strategy for fighting cancer.

Although it can take a bit of trial and error to discover which discipline strategies will work best for your child, these five factors can help you narrow down the most effective consequences.

Thanks to a lot of research as well as trial and error, I have found wonderful resources and powerful strategies for raising strong - willed children.

For full search methods used to populate Cochrane Pregnancy and Childbirth Group's Trials Register including the detailed search strategies for CENTRAL, MEDLINE, EMBASE and CINAHL, the list of handsearched journals and conference proceedings, and the list of journals reviewed via the current awareness service, please follow this link to the editorial information about the Cochrane Pregnancy and Childbirth Group in the Cochrane Library and select the «Specialized Register» section from the options on the left side of the screFor full search methods used to populate Cochrane Pregnancy and Childbirth Group's Trials Register including the detailed search strategies for CENTRAL, MEDLINE, EMBASE and CINAHL, the list of handsearched journals and conference proceedings, and the list of journals reviewed via the current awareness service, please follow this link to the editorial information about the Cochrane Pregnancy and Childbirth Group in the Cochrane Library and select the «Specialized Register» section from the options on the left side of the screfor CENTRAL, MEDLINE, EMBASE and CINAHL, the list of handsearched journals and conference proceedings, and the list of journals reviewed via the current awareness service, please follow this link to the editorial information about the Cochrane Pregnancy and Childbirth Group in the Cochrane Library and select the «Specialized Register» section from the options on the left side of the screen.

Although professional lactation support can improve the duration of overall breast feeding, its effect in improving exclusive breast feeding is unclear.11 18 22 Thus far, studies that report improvement of rates of exclusive breastfeeding have involved mainly community based peer counselling strategies.23 24 25 Even then, a randomised trial in the UK recently cast doubt on the efficacy of this approach.26 There are current recommendations from NICE for the UK - wide implementation of the baby friendly initiative.4 5 6 The 2006 NICE costing report on routine postnatal care of women and their babies estimates that efforts to improve rates of breast feeding will result in substantial cost savings for the NHS.6

A randomised trial in Brazil that compared a hospital based protocol (similar to the baby friendly hospital initiative) with another incorporating intensive home visits, however, found that while the protocol achieved high rates of exclusive breast feeding in hospital, the rates fell rapidly thereafter.27 These findings were confirmed in the UK by the millennium cohort study, 5 and the authors recommended that the baby friendly hospital initiative as a strategy for promotion of breast feeding should be reassessed and that other strategies are required to support mothers in the UK to breast feed for the recommended duration.5 27 Although combined antenatal education and postnatal support is ideal, this may be limited by economic or time resources.

Although some SIDS experts and policy - makers endorse pacifier use recommendations that are similar to those of the AAP, 272,273 concerns about possible deleterious effects of pacifier use have prevented others from making a recommendation for pacifier use as a risk reduction strategy.274 Although several observational studies275, — , 277 have found a correlation between pacifiers and reduced breastfeeding duration, the results of well - designed randomized clinical trials indicated that pacifiers do not seem to cause shortened breastfeeding duration for term and preterm infants.278, 279 The authors of 1 study reported a small deleterious effect of early pacifier introduction (2 — 5 days after birth) on exclusive breastfeeding at 1 month of age and on overall breastfeeding duration (defined as any breastfeeding), but early pacifier use did not adversely affect exclusive breastfeeding duration.

We obtained potentially eligible trials identified by the search strategy as full - text papers and two authors independently assessed each for inclusion.

Mr Gbagbo positioning himself as a victim of a French plot looks more like a strategy for his trial at the ICC, since he did not have any particular problems before that.

For now, the Republican political strategy seems to be mostly hoping that Mr. Cuomo, riding high in polls, self - destructs: that the transit woes of New York City's subways worsen; that the upcoming corruption trial of one of his former top aides, Joseph Percoco, tarnishes his image; that the state budget falls out of whack; that Democrats challenge and wound him from the left in a primary; and that the third term curse proves an actual curse.

NEW YORK, N.Y. — Standing with local community advocates and the brother of one former Rikers Island inmate held for three years without a trial, Brian Benjamin, Democratic nominee for the 30th District of the New York State Senate, and Council Member Rory Lancman, chair of the Committee on Courts and Legal Services, today unveiled a new strategy to close the city detention center within three years.

Now a University of Colorado Cancer Center study published online ahead of print in the journal Oncogene offers compelling evidence explaining this failure and offering a possible strategy for the use of retinoic acid or other retinoids against some breast cancers: Because early clinical trials are often offered to patients who have already tried other more established therapies, breast cancer cells may have been pushed past an important tipping point that offers retinoic acid resistance.

The link between yoga and better sleep was the only statistically significant finding in this MsFLASH (Menopause Strategies: Finding Lasting Answers for Symptoms and Health) Network randomized controlled trial.

The final results from an international clinical trial involving nearly 2,000 patients with Crohn's disease support the use of a new management strategy referred to as accelerated step - care as a best practice for the care of active Crohn's disease.

A clinical trial being conducted at the University of Kentucky is investigating a new treatment strategy for Parkinson's disease that, if successful, could drastically change future treatment of the disease and possibly halt or reverse brain degeneration.

«We observed rapid and durable protective immunity without adverse events, and so we think this candidate vaccine represents a promising strategy for the global fight against Zika virus,» said senior author Drew Weissman, MD, PhD, a professor of Infectious Disease at Penn. «We hope to start clinical trials in 12 to 18 months.»

Frustrated by the cost and the dead - slow pace of drug development, a group of researchers today launched a unique new strategy for running clinical trials.

A novel strategy to screen pregnant women for malaria with rapid diagnostic tests and treat the test - positive women with effective antimalarials does not lower the risk of adverse pregnancy outcomes compared with treating all pregnant women with the malaria preventive sulfadoxine - pyrimethamine (SP) in sub-Saharan Africa, according to an open label randomized trial published this week in PLOS Medicine by Feiko ter Kuile, of the Liverpool School of Tropical Medicine, and colleagues.

In a small trial, this strategy appeared to be safe and has shown promise for helping HIV patients.

... Finally, this study draws attention to the need for large controlled clinical trials to determine if a combination of fall prevention strategies and treatment with bone - active drugs might produce additive benefits on fractures, especially in high - risk populations such as those living in nursing homes.

«By helping us understand that lower levels of RNF125 confer resistance to BRAF inhibitors, we have a new strategy to stratify patients for currently approved therapy versus participation for human clinical trials to investigate whether targeting JAK1 will be more effective in patients whose tumors exhibit reduced RNF125,» said Keith T. Flaherty, M.D., associate professor, Harvard Medical School, and director of Developmental Therapeutics, Cancer Center, Massachusetts General Hospital, and co-author of the study.

An analysis of diagnostic test results from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial — in which patients with stable chest pain were randomized to either anatomic or functional testing as an initial diagnostic strategy — showed that the presence and extent of coronary artery disease detected by CT angiography better predicted the risk for future cardiac events than did measures of exercise tolerance or restricted blood flow to the heart muscle.

Larger, well - designed studies, such as cluster randomized trials, are ultimately needed to confirm the effectiveness of this strategy,» writes Alice Y. Guh, M.D., M.P.H., and L. Clifford McDonald, M.D., of the Centers for Disease Control and Prevention, Atlanta.

The PROMISE trial was conducted at 193 centers across North America to determine whether a care strategy starting with coronary CTA, which reveals the structure of blood vessels supplying the heart, or a strategy starting with functional testing, measures such as stress testing or echocardiography that reflect how well the heart muscle is working, provided better guidance for clinical decisions regarding patients with chest pain.

«We're planning clinical trials to study different treatment strategies for each of these types.»

A study among 701 children in southern Tanzania, published in 2001, showed that the treatment could reduce the number of cases of malaria; Gates's contribution will pay for bigger, multicountry trials that are needed to decide whether to widely implement the strategy.

In fact, the researchers point out that phase 1 clinical trials are already underway for compounds targeting this gene in other cancers, meaning that the time needed to apply a similar strategy to mucosal melanoma could be dramatically shorter than if they had to start from scratch.

«This study presents a novel strategy for treating multiple myeloma, and we hope to bring it to patients as part of a phase I clinical trial as soon as possible,» Hofmeister says.

This not only enables clinicians to rapidly employ tailored treatment strategies, but also provides for the development of future therapies in the form of new clinical trials,» adds Dr. Rodriguez, who is also a professor of obstetrics, gynecology and reproductive sciences at Rutgers Robert Wood Johnson Medical School.

Our results suggest the need for future studies involving long - term ambulatory cardiac monitoring to better delineate the risk associated with transient vs persistent perioperative AF, as well as randomized clinical trials to determine optimal strategies for antithrombotic therapy in patients with perioperative AF and a significant burden of other risk factors for stroke,» the authors write.

«This was the first trial to use HRD to select patients for treatment and showed that it is a useful strategy.

The neonatology study centers, for example, hewed to OHRP suggestions regarding the SUPPORT trial in adding warnings to documents for the network's Transfusion of Prematurity study, which compares two types of blood transfusion strategies in extreme preemies.

And $ 100 million (in addition to an existing $ 361 million) would go for diagnostic test development, genome sequencing, a clinical trial network, and other research as NIH's contribution to a trans - agency National Strategy to Combat Antibiotic Resistance.

Those groups have been hoping that the U.K. government will soon give its approval for clinical trials of strategy, but there have been some questions of safety and ethics since the approach arguably could create a child with three genetic parents — the donor egg is stripped of its own nuclear DNA but retains its mitochondria, which have DNA themselves.

That afternoon in Darrow's office three of us from the University of Chicago - Horatio Hackett Newman, professor of biology; Shailer Mathews, dean of the Divinity School; and I - met to outline the strategy for what turned out to be one of the most publicized trials of the century.

Based on these preclinical findings, CRI provides a seed grant for a phase I clinical trial to test the strategy in patients with metastatic renal cell carcinoma.

The EHDN supports HD research and clinical development at all stages, from basic and applied science through to the development of new treatment strategies, clinical assessment tools, and best clinical practice guidelines, to site feasibility assessment, site selection and patient recruitment for clinical trials.

Strategies to manipulate the PD - 1 pathway are currently being tested in clinical trials for cancer and HIV / AIDS.

Along with our nonprofit partners, this program aims to collect, organize, and validate massive amounts of data generated by clinical trials across our global trial network sites in order to generate novel insights into biomarkers for safety and efficacy, novel treatment strategies, and personalization of treatment regimens.

He led Daiichi Sankyo's international research unit focused on early oncology therapeutic programs, strategy and development, and was accountable for development activities from post-target identification basic science research to first - in - man trials and proof - of - clinical concept.