Sentences with phrase «trial of adjuvant»

A Phase III Randomized Trial of Adjuvant Chemotherapy with or without Bevacizumab for Patients with Completely Resected Stage IB (> or = 4 cm)- IIIA Non-Small Cell Lung Cancer (NSCLC)

Not exact matches

In a phase 2 trial that included nearly 1,000 adults, the AS03 and MF59 adjuvants (a component that improves immune response of inactivated influenza vaccines) increased the immune responses to two doses of an inactivated H7N9 influenza vaccine, with AS03 - adjuvanted formulations inducing the highest amount of antibody response, according to a study in the July 21 issue of JAMA.

We are currently waiting for the results of several trials including EORTC 1325 which is investigating pembrolizumab, a PD - 1 checkpoint blocking antibody, compared to placebo in the adjuvant setting.»

In my experience, this marks both the first clinical trial of an approved drug with an effect on survival in advanced melanoma in the adjuvant setting, and, in this same setting, the first to study an immune checkpoint inhibitor in the adjuvant setting.

Trial # 1: A phase I / II trial of HCQ in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiTrial # 1: A phase I / II trial of HCQ in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multitrial of HCQ in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

Appearing in Lancet Oncology, long term results of EORTC trial 22921 with 10.4 years median follow - up show that 5 - FU (fluorouracil) based adjuvant chemotherapy after preoperative (chemo)- radiotherapy for patients with cT3 - resectable T4 M0 rectal cancer does not improve survival or disease - free survival.

Results of EORTC trial 22921 show that compliance with adjuvant chemotherapy was poor, and only 42.9 % of the patients received the planned dose within the scheduled time frame.

They also need statisticians to design more efficient clinical trials, structural biologists to discover what features of molecules elicit what immunity, and chemists to develop adjuvants, the chemical agents that boost the immune reaction to a vaccine.

EORTC trial 22921 explored the value of adding chemotherapy to preoperative radiotherapy either concurrently, or as an adjuvant, or both for patients with cT3 - resectable T4 M0 rectal cancer.

Scientists hope that giving a booster within a year of the first jab and a new adjuvant will lead to a stronger and longer - lasting response against HIV and its V2 region, says Kim who is helping to design the trials.

Based on these results, two phase 3 trials are being planned for platinum - sensitive and platinum - resistant ovarian cancer patients by one of NCI's new National Cancer Trial Network Groups, the NRG Oncology Group (formerly 3 cooperative groups: the National Surgical Adjuvant Breast and Bowel Project (NSABP), the Radiation Therapy Oncology Group (RTOG), and the Gynecologic Oncology Group (GOG).

However he also stressed that the results did not lead him to conclude that there was no role for adjuvant radiation in this setting, pointing out that this was a phase II trial, and therefore not necessarily the final conclusion, and that selection of patients with differing pathology, stage and performance could influence outcome.

Now there is a need for clinical trials with humans in order to verify its safety as an adjuvant in the treatment of leishmaniasis.

Helmut Oettle, M.D., Ph.D., of the Charite - Universitatsmedizin Berlin, Germany, and colleagues conducted follow - up of a randomized trial that previously reported improvement in disease - free survival with adjuvant (in addition to surgery) gemcitabine therapy to determine if this treatment improved overall survival.

The degree of involvement of regional lymph nodes is predictive of overall survival and is also a key factor in determining the appropriateness of adjuvant therapy and the patient's eligibility for investigational trials.

Interferon alfa - 2b adjuvant therapy of high - risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684.

This has yielded three Tuberculosis vaccine candidates undergoing phase IIa testing and three first - in - human trials of novel CMI - inducing adjuvants.

Adjuvant lymph - node field radiotherapy versus observation only in patients with melanoma at high risk of further lymph - node field relapse after lymphadenectomy (ANZMTG 01.02 / TROG 02.01): 6 - year follow - up of a phase 3, randomised controlled trial.

PALLAS: Palbociclib Collaborative Adjuvant Study: A Randomized Phase III Trial of Palbociclib with Standard Adjuvant Endocrine Therapy versus Standard Adjuvant Endocrine Therapy Alone for Hormone Receptor Positive (HR +) / Human Epidermal Growth Factor Receptor 2 (HER2)- Negative Early Breast Cancer

Phase III Randomized, Placebo - Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy + / - One Year of Everolimus in Patients with High - Risk, Hormone Receptor - Positive and HER2 / neu Negative Breast Cancer.

[6] In the MSLT - 1 trial, patients with isolated nodal recurrence had more total lymph nodes involved by melanoma than patients randomized to SLN biopsy who had a positive biopsy (all of whom were to have CLND; an average of 3.2 lymph nodes involved with metastatic melanoma vs only 1.4 positive nodes, respectively; P <.0001), [2] and were more likely to meet established criteria for adjuvant radiation, [7] which further increases the risk of postoperative lymphedema.

A Randomized, Phase III Trial to Evaluate The Efficacy and Safety of MK - 3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor - Negative Breast Cancer with ≥ 1 cm Residual Invasive Cancer or Positive Lymph Nodes (yPN +) After Neoadjuvant Chemotherapy

Currently, lymphadenectomy is an eligibility requirement for cutting - edge adjuvant therapy trials such as Southwest Oncology Group (SWOG) 1404 (ClinicalTrials.gov identifier: NCT02506153), which randomizes stage III melanoma patients to an anti — programmed death 1 antibody or standard - of - care adjuvant therapy (high - dose interferon or high - dose ipilimumab).

Edward Creagan and John M. Kirkwood commence the first rigorous adjuvant trials of recombinant interferons for resectable melanoma.

While it is not possible to compare antibody levels measured in this trial with those seen in trials of other AMA1 vaccines, based on the relative fold - rise and duration of antibody responses this profile compares favorably with much lower and shorter - lived increases in antibody levels observed in Malian children immunized with AMA1 - C1, an AMA1 vaccine adjuvanted with aluminum hydroxide [19], which provided no measurable protection in a recently reported Phase 2 trial at another site in Mali.

In the BEVERLY - 1 (UCBG - 0802) trial we aimed to assess the addition of bevacizumab to neoadjuvant and adjuvant chemotherapy in the treatment of patients with HER2 - negative inflammatory breast cancer.

METHODS: This randomized, multicenter, placebo - controlled, double - blind trial of IM AN1792 225 microg plus the adjuvant QS - 21 50 microg (300 patients) and saline (72 patients) included patients aged 50 to 85 years with probable AD, Mini-Mental State Examination (MMSE) 15 to 26.

In the regulatory affairs arena, her group provides the necessary documentation to the U.S. Food and Drug Administration for review and approval of IDRI's vaccine and adjuvant candidates in human clinical trials.

This has yielded three TB vaccine candidates undergoing phase IIa testing and three first - in - human trials of novel CMI - inducing adjuvants.

Mature results of a phase III randomized trial of bacillus Calmette - Guerin (BCG) versus observation and BCG plus dacarbazine versus BCG in the adjuvant therapy of American Joint Committee on Cancer stage I - III melanoma (E1673).

A phase I / II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme.

Whereas, a phase I / II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme led to no significant improvement in overall survival, which could be due to inconsistent autophagy inhibition in patients treated with this regimen [29].

Tonight, in the Queen's realm of Ilance, two prodigies representing the Knight and Aristocrat factions will do battle in «the Adjuvant Trial».

Play as either Lucrezia Visconti or Francesca Storaro and battle your way up the tower through hordes of oncoming monsters to learn the secrets behind the Adjuvant Trial!

Adjuvant radiation and chemotherapy may be of value for advanced cases; however, adequate clinical trials have not been done in the dog or cat.

Each girl has been chosen to participate in the Adjuvant Trial, where they battle through a multi-level tower in hopes of winning military authority and the honor of protecting the queen.