Sentences with phrase «trial studies suggested»

Trial studies suggested that fish oil could help, but larger clinical trials proved inconclusive — possibly because the trials involved people with advanced cancers that were difficult to treat.

An industry - funded, randomized, double blind, placebo - controlled crossover trial study suggests chocolate may improve symptoms for those suffering from chronic fatigue syndrome — a debilitating condition currently affecting as many as seven million Americans.

Not exact matches

Some small studies have suggested that synbiotics could provide benefits to a range of other conditions influenced by the gut microbiome as well, including obesity, diabetes, and non-alcoholic fatty liver disease, but larger - scale clinical trials focusing on each of those conditions are needed.

Answer: Studies suggest no improvement in performance, either in endurance or speed (time trial performance).

It is considered the lowest form of evidence, ranked far below randomized trials and observational studies, which in this case all suggest that cry - it - out is not harmful.

Although this study was not powered to assess the impact of mother — infant sleep proximity on long - term breastfeeding outcomes, these indicative data suggested that such a trial was warranted; this trial is now underway and due to report in 2010.

Studies have suggested antioxidant supplements has benefits for health, but several large clinical trials did not demonstrate a definite benefit for the formulations tested, and excess supplementation may even be harmful.

Although these facts do not mean that the results are invalid, a 2003 study published in the British Medical Journal suggests that trials funded by drug companies are more likely to report favorable results about their products than are trials funded by independent organizations.

The study looks at data on 26 side effects from a trial of approximately 10,000 patients and suggests that cases of muscle pain and weakness are unlikely to be directly caused by statins, but may instead be due to the so - called nocebo effect, where the expectation of side effects can make patients more likely to report them.

Small - scale studies have suggested that the nets do work, but there haven't been any large - scale clinical trials.

Previous studies have suggested that various forms of meditation can improve attention and reduce stress, but there have been few randomised controlled trials — the best way of testing a treatment's effectiveness.

«We know that urate has neuroprotective properties in animal models, and an unusual convergence of human studies suggested its possible use as a disease - modifying strategy in Parkinson's; so the positive results of this trial are very encouraging.»

Drugs that disrupt the enzyme, his animal studies suggest, could prevent Alzheimer's with less risk of unwanted side effects — an approach that he expects to begin testing in human trials within three years.

Although these studies are only proofs of principle — many more trials must happen before a drug could be approved — they suggest that oxytocin, if delivered soon after a diagnosis of autism, could help sway early social interactions in favor of more normal development.

The second study was led by cardiologist Steven Nissen at the Cleveland Clinic in Ohio; it was Nissen who, 3 years ago, set off the Avandia firestorm with a meta - analysis of 42 Avandia trials that he said suggested an increased risk of heart attack.

«It was clear from our findings that many people with IBS should have their vitamin D levels tested, and the data suggests that they may benefit from supplementation with vitamin D. «As a result of this exploratory study, we're now able to design and justify a larger and more definitive clinical trial.»

But cognitive studies suggest primates use tools mainly by trial and error, whereas humans understand the principles at work — such as gravity and force — and exploit them to make novel tools.

«Nondrug approaches effective for treatment of common pain conditions, review suggests: US study reviews trial results on complementary health approaches for pain relief; aims to assist with pain management.»

Although epidemiological studies have suggested that moderate drinking can lower a person's risk of heart attack or stroke, that possibility has not been studied in a randomized trial with a control group.

«We don't know what exposure is leading to this susceptibility to dietary glutamate, but this pilot study suggests the need for a large - scale clinical trial, since dietary change could be an effective low - cost treatment option for developing countries.»

The trial, stopped at the end of 2004, suggests that naproxen is associated with a higher risk of heart and stroke problems than Celebrex is — a finding that contradicts many other published studies.

Our study is not a definitive randomized clinical trial, but it does suggest that we are over-testing and over-treating these patients.»

However, a new study by University of California San Diego School of Medicine researchers suggests that, despite promising results in clinical trials, smoking cessation drugs alone may not be improving the chances of successful quitting among smokers in general.

«Previous studies suggest that reducing heart fat is feasible through weight loss or weight management, but these studies only looked at small numbers of people and there have been no clinical trials linking cardiovascular outcomes with heart fat changes due to weight management interventions.

Laboratory studies have suggested that it may have anti-cancer properties, although results from human trials have been mixed.

«While the present report suggests that optimal outcome measures for FXS are not yet fully developed, the recent failures of clinical trials in the FXS treatment field represent an opportunity to implement novel study designs and methodologies,» concludes Budimirovic.

The study is investigator led and has therefore focused on clinical need, targeting patients with progressive multiple sclerosis in whom most disability is incurred... The study also reports a predominant effect on neurodegenerative rather than inflammatory outcomes, suggesting a novel mechanism of action that might be suitable as combination treatment with immunomodulatory treatments... Further phase 3 studies to measure the effect of simvastatin on sustained disability, particularly in patients with non-relapsing secondary progressive and primary progressive multiple sclerosis, are clearly needed, but this trial represents a promising point from which to develop trials of progressive disease.»

The authors suggest that combining pharmacological data from spaceflights with equivalent ground - based studies investigating menstrual suppression might provide the evidence required to trial LARCs during spaceflight.

Results from recent clinical trials and studies in animals suggest that a class of anti-cancer drugs called angiogenesis inhibitors may be able to temporarily reduce interstitial pressure and improve the efficacy of chemotherapy and radiation treatments.

Based on this review, they suggest a «probable» association between vitamin D levels and birth weight, dental caries in children, maternal vitamin D levels at term and parathyroid hormone levels in chronic kidney disease patients requiring dialysis, but «further studies and better designed trials are needed to draw further conclusions.»

These findings also suggest a mechanistic basis for potential treatments involving the painless electrical stimulation of the amygdala, which are currently being studied in ongoing clinical trials.

She suggested that this SAMPRISS trial, as it was called, would be a good model for future post-market studies, though she also argued that the FDA should have more authority to recall unsafe and ineffective devices after approval.

The drug has already demonstrated safety in nonhuman primate trials, and the cardiovascular research might even be able to skip ahead to a larger phase II trial based on safety data from the ongoing phase I studies, Leeper suggests.

Our results suggest the need for future studies involving long - term ambulatory cardiac monitoring to better delineate the risk associated with transient vs persistent perioperative AF, as well as randomized clinical trials to determine optimal strategies for antithrombotic therapy in patients with perioperative AF and a significant burden of other risk factors for stroke,» the authors write.

Common bias safeguards used in clinical trials not always followed in animal research, study suggests

«This work suggests that we need to tease out the mechanisms by which COPD may increase lung cancer risk in smokers, and to conduct clinical trials to determine whether treating COPD in former and current smokers lessens that risk,» said David Christiani, Elkan Blout Professor of Environmental Genetics at Harvard Chan School and senior author of the study.

But they suggest that using tools to predict brain age could be clinically useful in helping patients understand their brain health relative to their age and in clinical trials where it might improve study design and recruitment.

A body of literature based on observational studies and secondary CHD prevention trials of short - acting CCBs has suggested that CCBs, especially DHP - CCBs, may increase the risk of cancer, gastrointestinal bleeding, and all - cause mortality.14, 36,37 The results of ALLHAT do not support these findings.

Just hours before this latest Cleveland Clinic Lerner Research Institute study was published, another blow to the field came when Merck announced it was discontinuing a Phase 3 clinical trial into a drug called verubecestat, following a recommendation suggesting, «it was unlikely that positive benefit / risk could be established if the trial continued.»

Previous research (the Gynecologic Oncology Group's GOG181B trial) has suggested that trastuzumab is inactive in HER2 / neu - expressing endometrial carcinomas, and in the current study, nearly half of the participants «ultimately did not have tumoral HER2 / neu gene amplification,» Dr. Santin said.

Preclinical studies suggested poor bioavailability with a consequent in vivo ineffectiveness for compound 182a [2, 97], while compound 182b entered clinical trials, unfortunately its development was soon suspended [98, 99].

Various types of meditation have been shown to improve well - being among different populations such as physicians and the general public.14, 15, 16 Preliminary evidence suggests that meditation - based interventions may slow cellular aging rates by increasing telomerase activity, but many such studies lacked an active control group.17, 18 Recent randomized trials in breast cancer suggest that long - term intensive meditation interventions might have positive effects on telomerase activity.

The stated enrollment goals suggest the intent to recruit all subjects from the original trial into both studies, which appears to be impossible per the stated protocols.

A malaria vaccine has shown promising results in early stage clinical trials, a study suggests.

A new animal study involving virally - delivered gene therapies has indicated that high treatment doses might not be as safe as previous human trials have suggested

Potential cardioprotection was based on generally supportive data on lipid levels in intermediate outcome clinical trials, trials in nonhuman primates, and a large body of observational studies suggesting a 40 % to 50 % reduction in risk among users of either estrogen alone or, less frequently, combined estrogen and progestin.2 - 5 Hip fracture was designated as a secondary outcome, supported by observational data as well as clinical trials showing benefit for bone mineral density.6, 7 Invasive breast cancer was designated as a primary adverse outcome based on observational data.3, 8 Additional clinical outcomes chosen as secondary outcomes that may plausibly be affected by hormone therapy include other cardiovascular diseases; endometrial, colorectal, and other cancers; and other fractures.3, 6,9

4/26/2007 UCSD to Participate in Nationwide Trial to Assess Impact of Omega - 3 Fatty Acid on the Progression of Alzheimer's Disease Nutritionists have long endorsed fish as part of a heart - healthy diet, and now some studies suggest that omega - 3 fatty acids found in the oil of certain fish and algae as well as human breast milk may also benefit the brain by lowering the risk of Al...

«Although it is known that statins do increase the risk of diabetes, the best available evidence about the size of this excess risk comes from randomised trials, which have suggested a much smaller risk than was found in this study.

Not only is vitamin D deficiency a risk factor for osteoporosis, but epidemiological studies and randomized, controlled trials suggest a correlation with diseases including cardiovascular disease, some cancers, respiratory infections, and multiple sclerosis.

Tamoxifen may not be right for older women You can expect to take any of these drugs once a day for five years — although a 2007 study in the journal Cancer suggests that tamoxifen may be on its way out for breast cancer survivors who've passed menopause: Two multicenter trials found that when women who'd been taking tamoxifen for two or three years switched to an AI, their survival rates significantly improved compared with continuing on with tamoxifen.